GB1499582A - Substituted tetrahydrobenzothiophenes - Google Patents
Substituted tetrahydrobenzothiophenesInfo
- Publication number
- GB1499582A GB1499582A GB1592/75A GB159275A GB1499582A GB 1499582 A GB1499582 A GB 1499582A GB 1592/75 A GB1592/75 A GB 1592/75A GB 159275 A GB159275 A GB 159275A GB 1499582 A GB1499582 A GB 1499582A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- nhr1
- radical
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
Abstract
The novel compounds correspond to the formula: <IMAGE> in which X, Y, Z, R1, R2, R3 and U have the meanings given in Claim 1. They are prepared by a) reacting one mol equivalent of a compound of the formula I or II, in which the -NR1-CX-NHR1 radical is replaced, or its acid addition salts with 1 to 1.5 mol equivalents of R2NCX or b) reacting one mol equivalent of an acid addition salt of a compound of the formula I or II, in which R2 and R3 denotes hydrogen and the -NR1-CX-NHR2 radical is replaced by -NHR1, with 1 to 1.5 mol equivalents of a compound of the formula MeNCX, in which Me denotes sodium or potassium, and isolating the product. The reaction (a) is carried out in water or an inert organic solvent at 0 to 100 DEG C. The reaction (b) is carried out in aqueous medium at pH = 5 to 7 and 10 to 80 DEG C. The novel compounds of the formulae I and II are administered orally to warm-blooded animals to improve the extent of the feed effect and to increase the growth rate. A supplementary feed for increasing the growth rate of poultry, fur-bearing animals and agricultural productive animals contains 70 to 99% by weight of an edible carrier and, as the remainder, a novel compound of the formula I or II.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43682674A | 1974-01-25 | 1974-01-25 | |
US43682774A | 1974-01-25 | 1974-01-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1499582A true GB1499582A (en) | 1978-02-01 |
Family
ID=27031116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1592/75A Expired GB1499582A (en) | 1974-01-25 | 1975-01-14 | Substituted tetrahydrobenzothiophenes |
Country Status (21)
Country | Link |
---|---|
JP (1) | JPS51125069A (en) |
AT (1) | AT353590B (en) |
CA (1) | CA1060899A (en) |
CH (4) | CH619703A5 (en) |
CS (1) | CS195276B2 (en) |
DD (4) | DD119790A5 (en) |
DE (1) | DE2501788C2 (en) |
DK (1) | DK22775A (en) |
ES (1) | ES434095A1 (en) |
FR (1) | FR2333801A1 (en) |
GB (1) | GB1499582A (en) |
IE (1) | IE42039B1 (en) |
IL (1) | IL46375A (en) |
IN (1) | IN141050B (en) |
IT (1) | IT1035548B (en) |
LU (1) | LU71711A1 (en) |
NL (1) | NL7500845A (en) |
PH (1) | PH14544A (en) |
SE (1) | SE421617B (en) |
TR (1) | TR18381A (en) |
YU (1) | YU36721B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007068330A1 (en) * | 2005-12-16 | 2007-06-21 | Merck Patent Gmbh | 2-ADAMANTYLUREA DERIVATIVES AS SELECTIVE 11β-HSD1 INHIBITORS |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3994924A (en) * | 1975-11-04 | 1976-11-30 | American Cyanamid Company | 4,5,6,7-Tetra hydro-7-oxobenzo(B)thien-4-yl isocyanate and isothiocyanate |
FR2430231A1 (en) * | 1978-07-04 | 1980-02-01 | American Cyanamid Co | 4,5,6,7-Tetra:hydro-benzo(b)thienyl-4 urea and 7-oxo deriv. compsn. - used for increasing growth of wool and ratio of sec. to prim. follicles in sheep, goats, llamas, rabbits and chinchilla |
JPS6169772A (en) * | 1984-12-04 | 1986-04-10 | アメリカン サイアナミッド カンパニ− | Tetrahydrobenzo(b)thiophene derivative, manufacture and animal growth acceleration |
-
1974
- 1974-12-31 CA CA217,189A patent/CA1060899A/en not_active Expired
-
1975
- 1975-01-01 IL IL46375A patent/IL46375A/en unknown
- 1975-01-02 IN IN20/CAL/75A patent/IN141050B/en unknown
- 1975-01-06 IE IE26/75A patent/IE42039B1/en unknown
- 1975-01-10 PH PH16699A patent/PH14544A/en unknown
- 1975-01-14 GB GB1592/75A patent/GB1499582A/en not_active Expired
- 1975-01-17 DE DE2501788A patent/DE2501788C2/en not_active Expired
- 1975-01-21 AT AT42675A patent/AT353590B/en not_active IP Right Cessation
- 1975-01-22 CS CS75448A patent/CS195276B2/en unknown
- 1975-01-23 LU LU71711A patent/LU71711A1/xx unknown
- 1975-01-23 FR FR7502174A patent/FR2333801A1/en active Granted
- 1975-01-24 DK DK22775*BA patent/DK22775A/da not_active Application Discontinuation
- 1975-01-24 DD DD183814A patent/DD119790A5/xx unknown
- 1975-01-24 DD DD192555A patent/DD125211A5/xx unknown
- 1975-01-24 DD DD192556A patent/DD125212A5/xx unknown
- 1975-01-24 SE SE7500793A patent/SE421617B/en not_active IP Right Cessation
- 1975-01-24 IT IT47844/75A patent/IT1035548B/en active
- 1975-01-24 DD DD192557A patent/DD125213A5/xx unknown
- 1975-01-24 YU YU0172/75A patent/YU36721B/en unknown
- 1975-01-24 CH CH87775A patent/CH619703A5/en not_active IP Right Cessation
- 1975-01-24 NL NL7500845A patent/NL7500845A/en not_active Application Discontinuation
- 1975-01-24 ES ES434095A patent/ES434095A1/en not_active Expired
- 1975-01-25 JP JP50010184A patent/JPS51125069A/en active Granted
- 1975-01-27 TR TR18381A patent/TR18381A/en unknown
-
1978
- 1978-09-29 CH CH1016778A patent/CH619949A5/en not_active IP Right Cessation
- 1978-09-29 CH CH1016878A patent/CH619705A5/en not_active IP Right Cessation
- 1978-09-29 CH CH1016678A patent/CH619704A5/en not_active IP Right Cessation
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007068330A1 (en) * | 2005-12-16 | 2007-06-21 | Merck Patent Gmbh | 2-ADAMANTYLUREA DERIVATIVES AS SELECTIVE 11β-HSD1 INHIBITORS |
EP1801098A1 (en) * | 2005-12-16 | 2007-06-27 | Merck Sante | 2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors |
US8188288B2 (en) | 2005-12-16 | 2012-05-29 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 2-adamantylurea derivatives as selective 11beta-HSD1 inhibitors |
EA017923B1 (en) * | 2005-12-16 | 2013-04-30 | Мерк Патент Гмбх | 2-ADAMANTYLUREA DERIVATIVES AS SELECTIVE 11β-HSD1 INHIBITORS |
US8466200B2 (en) | 2005-12-16 | 2013-06-18 | Merck Patent Gmbh | 2-adamantylurea derivatives as selective 11β-HSD1 inhibitors |
Also Published As
Publication number | Publication date |
---|---|
CH619705A5 (en) | 1980-10-15 |
JPS51125069A (en) | 1976-11-01 |
AT353590B (en) | 1979-11-26 |
DD125213A5 (en) | 1977-04-06 |
IL46375A0 (en) | 1975-04-25 |
SE7500793L (en) | 1975-07-28 |
IN141050B (en) | 1977-01-15 |
CA1060899A (en) | 1979-08-21 |
ATA42675A (en) | 1979-04-15 |
CH619704A5 (en) | 1980-10-15 |
FR2333801B1 (en) | 1982-07-09 |
FR2333801A1 (en) | 1977-07-01 |
PH14544A (en) | 1981-09-24 |
LU71711A1 (en) | 1975-06-24 |
JPS6133830B2 (en) | 1986-08-04 |
CH619949A5 (en) | 1980-10-31 |
IE42039B1 (en) | 1980-05-21 |
CS195276B2 (en) | 1980-01-31 |
DK22775A (en) | 1975-09-15 |
DE2501788A1 (en) | 1975-07-31 |
IL46375A (en) | 1982-04-30 |
IT1035548B (en) | 1979-10-20 |
IE42039L (en) | 1975-07-25 |
DD125211A5 (en) | 1977-04-06 |
SE421617B (en) | 1982-01-18 |
NL7500845A (en) | 1975-07-29 |
YU17275A (en) | 1982-06-18 |
DD119790A5 (en) | 1976-05-12 |
DD125212A5 (en) | 1977-04-06 |
ES434095A1 (en) | 1977-05-16 |
DE2501788C2 (en) | 1984-11-08 |
AU7691574A (en) | 1976-07-01 |
TR18381A (en) | 1977-05-01 |
YU36721B (en) | 1984-08-31 |
CH619703A5 (en) | 1980-10-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SU648103A3 (en) | Method of obtaining tetrazol (1,5-a)-quinolines or salts thereof | |
GB1425354A (en) | Indole derivatives | |
GB1499582A (en) | Substituted tetrahydrobenzothiophenes | |
US2772280A (en) | Synthesis of 4-amino-3-isoxazolidone and its derivatives | |
ES400824A1 (en) | Amidinocarbamates | |
GB1132621A (en) | Process for preparing cephalosporin c antibiotics | |
GB1427160A (en) | Oxazolidines and oxazolidinones and process for their production | |
ES8206535A1 (en) | Improvement in the method for producing 7-aminocephem compounds. | |
IE810547L (en) | Stabilization of pleuromutilin derivatives against oxidation | |
US4199510A (en) | Process for oxidation of 4-amidotetrahydrobenzo [b]-thiophenes to 7-keto derivatives with cobaltic salts | |
GB1285790A (en) | Acylaminopenicillanic acids and process for preparing them | |
US3932439A (en) | N-substituted cycloserine compounds, salts thereof, and processes for preparing them | |
US2855395A (en) | Phthalides | |
CA1087616A (en) | Preparation of quinoxaline-1,4-dioxides and intermediates therefor | |
SU1189346A3 (en) | Method of producing quinoxaline derivatives | |
US4173581A (en) | Process for the preparation of alkylthiosemicarbazides | |
SE8003311L (en) | MALEIC ACID SALT OF 2-PHENYL-6- (1-HYDROXY-2-T-BUTYL-AMINOETHYL-4H-PYRIDO (3,2-D) -1,3-DIOXIN | |
SU521276A1 (en) | The method of obtaining derivatives simm-triazine | |
SU598900A1 (en) | Method of obtaining derivatives of 8-azaxanthine | |
GB1397997A (en) | O-pyrazolo-pyrimidine-thiono-phsophoric -phosphinic- acid esters process for their production and their use as insecticides and acaricides | |
GB1408653A (en) | Production of diamino-alpha,alpha,-dianthraquinonyls | |
US3262848A (en) | Poultry enterohepatitis treating compositions and methods of using same | |
DE2906843A1 (en) | 7- ANGLE CLAMP ON ANGLE CLAMP ON AMINO (1,3-DIHYDROBENZO ANGLE CLAMP ON C ANGLE CLAMP ON THIENYL) ACETYL SQUARE CLAMP ON AMINO SQUARE CLAMP ON CEPHALOSPORINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF | |
GB1469410A (en) | Benzodioxole derivatives | |
SU437764A1 (en) | Method for preparing 5 (4) -thi-imidazole derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |