GB1498633A - 2-phenyl-piperazines and 4-phenyl-hexahydro pyrimidines - Google Patents
2-phenyl-piperazines and 4-phenyl-hexahydro pyrimidinesInfo
- Publication number
- GB1498633A GB1498633A GB39732/76A GB3973276A GB1498633A GB 1498633 A GB1498633 A GB 1498633A GB 39732/76 A GB39732/76 A GB 39732/76A GB 3973276 A GB3973276 A GB 3973276A GB 1498633 A GB1498633 A GB 1498633A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- prepared
- salt
- compounds
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RIMRLBGNCLMSNH-UHFFFAOYSA-N 2-phenylpiperazine Chemical class C1NCCNC1C1=CC=CC=C1 RIMRLBGNCLMSNH-UHFFFAOYSA-N 0.000 title abstract 2
- MSVBZOAXZMFSLS-UHFFFAOYSA-N 4-phenyl-1,3-diazinane Chemical class N1CNCCC1C1=CC=CC=C1 MSVBZOAXZMFSLS-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 14
- 150000003839 salts Chemical class 0.000 abstract 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 230000002140 halogenating effect Effects 0.000 abstract 3
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 2
- FCSKOFQQCWLGMV-UHFFFAOYSA-N 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole Chemical compound O1N=C(C)C=C1CCCCCOC1=CC=C(C=2OCCN=2)C=C1Cl FCSKOFQQCWLGMV-UHFFFAOYSA-N 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- AWMVMTVKBNGEAK-UHFFFAOYSA-N Styrene oxide Chemical compound C1OC1C1=CC=CC=C1 AWMVMTVKBNGEAK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NLAANVRAGE7401807,A NL179906C (nl) | 1974-02-09 | 1974-02-09 | Werkwijze voor het bereiden van 1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino (1,2-a)azepine derivaten. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1498633A true GB1498633A (en) | 1978-01-25 |
Family
ID=19820725
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB39732/76A Expired GB1498633A (en) | 1974-02-09 | 1975-01-28 | 2-phenyl-piperazines and 4-phenyl-hexahydro pyrimidines |
| GB3670/75A Expired GB1498632A (en) | 1974-02-09 | 1975-01-28 | Preparation of 1,2,3,4,10,14b-hexahydro-dibenzo(c,f)-pyrazino(1,2-a)azepines and 1,2,3,4,10,14b-dibenzo-(c,f)-pyrimidino(3,4-a)-azepines |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3670/75A Expired GB1498632A (en) | 1974-02-09 | 1975-01-28 | Preparation of 1,2,3,4,10,14b-hexahydro-dibenzo(c,f)-pyrazino(1,2-a)azepines and 1,2,3,4,10,14b-dibenzo-(c,f)-pyrimidino(3,4-a)-azepines |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US4025513A (en, 2012) |
| JP (1) | JPS5315520B2 (en, 2012) |
| CA (1) | CA1084490A (en, 2012) |
| CH (1) | CH613705A5 (en, 2012) |
| DE (1) | DE2505239A1 (en, 2012) |
| DK (1) | DK150144C (en, 2012) |
| ES (1) | ES434533A1 (en, 2012) |
| FI (1) | FI57106C (en, 2012) |
| FR (1) | FR2260579B1 (en, 2012) |
| GB (2) | GB1498633A (en, 2012) |
| HU (1) | HU169018B (en, 2012) |
| NL (1) | NL179906C (en, 2012) |
| SE (1) | SE418745B (en, 2012) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2138016A (en) * | 1983-04-05 | 1984-10-17 | Bostik Ltd | Adhesive bonding |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217452A (en) | 1974-02-09 | 1980-08-12 | Akzona Incorporated | Synthesis for the preparation of tetracyclic compounds |
| NL179906C (nl) | 1974-02-09 | 1986-12-01 | Akzo Nv | Werkwijze voor het bereiden van 1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino (1,2-a)azepine derivaten. |
| JPS5655174U (en, 2012) * | 1979-10-06 | 1981-05-14 | ||
| DE3368634D1 (en) * | 1982-03-05 | 1987-02-05 | Beecham Group Plc | Pentacyclic compounds |
| US4515792A (en) * | 1982-09-30 | 1985-05-07 | Ciba-Geigy Corporation | Tetracyclic heterocycles and antidepressant compositions thereof |
| PT95522B (pt) * | 1989-10-05 | 1997-08-29 | Sankyo Co | Processo para a preparacao de novos compostos tetraciclicos com accao anti-alergica e anti-asmatica e de composicoes farmaceuticas que os contem |
| EP0539164A1 (en) * | 1991-10-23 | 1993-04-28 | Sankyo Company Limited | Nitrogen-containing tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use |
| DE4305659A1 (de) * | 1993-02-24 | 1994-08-25 | Heumann Pharma Gmbh & Co | Verfahren zur Herstellung von 1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepin und seiner Salze |
| EP1017695A4 (en) * | 1997-09-26 | 2002-01-16 | Univ Monash | RESOLUTION OF OPTICALLY ACTIVE COMPOUNDS |
| YU74201A (sh) | 1999-04-19 | 2004-05-12 | Teva Pharmaceutical Industries Ltd. | Nova sinteza prstena piperazina |
| WO2001025185A1 (fr) | 1999-09-30 | 2001-04-12 | Sumika Fine Chemicals Co., Ltd. | Procede de production de derive de piperazine |
| WO2009128057A2 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
| CN102649779A (zh) * | 2012-04-20 | 2012-08-29 | 山东鲁药制药有限公司 | 一种药物中间体1-甲基-3-苯基哌嗪的合成方法 |
| CN102911793B (zh) * | 2012-10-04 | 2013-10-23 | 盐城师范学院 | 一种功能化碱性离子液体及其在生物柴油制备中的应用 |
| CN102876466B (zh) * | 2012-10-05 | 2013-10-23 | 盐城师范学院 | 一种碱性离子液体催化酯交换反应的方法 |
| CN104892608B (zh) * | 2015-06-29 | 2017-06-20 | 山西康宝生物制品股份有限公司 | 一种米氮醇的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3190893A (en) * | 1961-02-17 | 1965-06-22 | Kefalas As | Method of producing 9, 10-dihydroanthracenes |
| CH420150A (de) * | 1961-12-18 | 1966-09-15 | Siegfried Ag | Verfahren zur Herstellung von 10-Aminoalkyl-5,5-dialkylacridanen |
| NL129434C (en, 2012) * | 1966-03-12 | |||
| US3808208A (en) * | 1970-02-02 | 1974-04-30 | Dow Chemical Co | P-benzodithino(dioxino)(2,3,-b)pyrazines |
| NL176458C (nl) * | 1972-09-23 | 1985-04-16 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat en werkwijze voor de bereiding van daartoe geschikte actieve stoffen. |
| NL179906C (nl) | 1974-02-09 | 1986-12-01 | Akzo Nv | Werkwijze voor het bereiden van 1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino (1,2-a)azepine derivaten. |
| DE2457971A1 (de) * | 1974-12-07 | 1976-06-10 | Merck Patent Gmbh | Verfahren zur herstellung von 2-acyl4-oxo-pyrazino-isochinolin-derivaten |
-
1974
- 1974-02-09 NL NLAANVRAGE7401807,A patent/NL179906C/xx active Search and Examination
-
1975
- 1975-01-28 GB GB39732/76A patent/GB1498633A/en not_active Expired
- 1975-01-28 GB GB3670/75A patent/GB1498632A/en not_active Expired
- 1975-01-30 DK DK032375A patent/DK150144C/da not_active IP Right Cessation
- 1975-02-06 FI FI750327A patent/FI57106C/fi not_active IP Right Cessation
- 1975-02-06 CH CH143875A patent/CH613705A5/xx not_active IP Right Cessation
- 1975-02-06 US US05/547,680 patent/US4025513A/en not_active Expired - Lifetime
- 1975-02-07 ES ES434533A patent/ES434533A1/es not_active Expired
- 1975-02-07 FR FR7503954A patent/FR2260579B1/fr not_active Expired
- 1975-02-07 DE DE19752505239 patent/DE2505239A1/de active Granted
- 1975-02-07 HU HUAO404A patent/HU169018B/hu unknown
- 1975-02-07 JP JP1615675A patent/JPS5315520B2/ja not_active Expired
- 1975-02-07 SE SE7501365A patent/SE418745B/xx not_active IP Right Cessation
- 1975-02-10 CA CA219,742A patent/CA1084490A/en not_active Expired
-
1979
- 1979-08-08 US US06/064,812 patent/US4254031A/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2138016A (en) * | 1983-04-05 | 1984-10-17 | Bostik Ltd | Adhesive bonding |
Also Published As
| Publication number | Publication date |
|---|---|
| FI57106B (fi) | 1980-02-29 |
| DK150144C (da) | 1987-10-19 |
| DE2505239C2 (en, 2012) | 1988-11-03 |
| JPS5315520B2 (en, 2012) | 1978-05-25 |
| DE2505239A1 (de) | 1975-08-14 |
| SE418745B (sv) | 1981-06-22 |
| FI750327A7 (en, 2012) | 1975-08-10 |
| FI57106C (fi) | 1980-06-10 |
| GB1498632A (en) | 1978-01-25 |
| CH613705A5 (en, 2012) | 1979-10-15 |
| FR2260579A1 (en, 2012) | 1975-09-05 |
| FR2260579B1 (en, 2012) | 1977-07-08 |
| US4254031A (en) | 1981-03-03 |
| DK150144B (da) | 1986-12-15 |
| DK32375A (en, 2012) | 1975-09-29 |
| US4025513A (en) | 1977-05-24 |
| NL179906C (nl) | 1986-12-01 |
| SE7501365L (en, 2012) | 1975-08-11 |
| JPS50108299A (en, 2012) | 1975-08-26 |
| HU169018B (en, 2012) | 1976-09-28 |
| CA1084490A (en) | 1980-08-26 |
| ES434533A1 (es) | 1976-12-01 |
| NL7401807A (nl) | 1975-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19950127 |