GB1174819A - Novel Derivatives of Piperazine and Method of Preparing the same - Google Patents

Novel Derivatives of Piperazine and Method of Preparing the same

Info

Publication number
GB1174819A
GB1174819A GB870467A GB870467A GB1174819A GB 1174819 A GB1174819 A GB 1174819A GB 870467 A GB870467 A GB 870467A GB 870467 A GB870467 A GB 870467A GB 1174819 A GB1174819 A GB 1174819A
Authority
GB
United Kingdom
Prior art keywords
piperazine
preparing
same
formula
novel derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB870467A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CRC Compagnie di Ricerca Chimica SpA
Original Assignee
CRC Compagnie di Ricerca Chimica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CRC Compagnie di Ricerca Chimica SpA filed Critical CRC Compagnie di Ricerca Chimica SpA
Publication of GB1174819A publication Critical patent/GB1174819A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,174,819. Piperazine derivatives. CRC COMPAGNIA DI RICERCHE CHIMICHE S.A. 23 Feb., 1967 [21 Nov., 1966], No. 8704/67. Heading C2C. Novel chlorobenzhydrylpiperazine derivatives of the Formula I wherein X is a halogen atom, are prepared by reacting chlorobenzhydrylpiperazine with a di- (haloethyl) ethers of the formula Y.CH 2 CH 2 O-CH 2 CH 2 Y (a) where Y is a halogen atom. The compounds may be hydrolysed to the compound of Formula I in which X is a hydroxy group.
GB870467A 1966-11-21 1967-02-23 Novel Derivatives of Piperazine and Method of Preparing the same Expired GB1174819A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1663166A CH505116A (en) 1966-11-21 1966-11-21 1-p-chlorobenzhydril-4-2-2-haloethoxy ethyl piperazines

Publications (1)

Publication Number Publication Date
GB1174819A true GB1174819A (en) 1969-12-17

Family

ID=4418900

Family Applications (1)

Application Number Title Priority Date Filing Date
GB870467A Expired GB1174819A (en) 1966-11-21 1967-02-23 Novel Derivatives of Piperazine and Method of Preparing the same

Country Status (4)

Country Link
JP (1) JPS4942517B1 (en)
CH (1) CH505116A (en)
ES (1) ES337123A1 (en)
GB (1) GB1174819A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0801064A1 (en) * 1996-04-10 1997-10-15 U C B, S.A. Process for the preparation of 2-(2-(4((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and their salts
WO1997037982A1 (en) * 1996-04-10 1997-10-16 Ucb S.A. Novel substituted [2-(1-piperazinyl)ethoxy]methyl
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0801064A1 (en) * 1996-04-10 1997-10-15 U C B, S.A. Process for the preparation of 2-(2-(4((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and their salts
WO1997037982A1 (en) * 1996-04-10 1997-10-16 Ucb S.A. Novel substituted [2-(1-piperazinyl)ethoxy]methyl
BE1010094A3 (en) * 1996-04-10 1997-12-02 Ucb Sa NEW [2- (1-piperazinyl) ethoxy] SUBSTITUTED.
BE1010095A3 (en) * 1996-04-10 1997-12-02 Ucb Sa METHOD OF PREPARATION OF ACID 2- [2- [4 - [(4-Chlorophenyl) phenylmethyl] -1-PIPERAZINYL] ETHOXY] acetic acid AND ITS SALTS.
EA000831B1 (en) * 1996-04-10 2000-04-24 ЮСиБи С.А. Novel substituted [2-(1-piperazinyle)etoxy]methyl compounds, method for preparing said compounds and the use thereof
US6140501A (en) * 1996-04-10 2000-10-31 Ucb, S.A. Substituted [2-(1-piperazinyl)ethoxy]methyl compounds
US6255487B1 (en) 1996-04-10 2001-07-03 Ucb, S.A. Process of preparing [2-(1-piperazinyl)ethoxy]methyl compounds
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
WO1999028310A1 (en) * 1997-11-26 1999-06-10 Ucb, S.A. Pseudopolymorphic forms of 2-[2-[4-[bis (4-fluorophenyl) methyl]-1-piperazinyl] ethoxy]acetic acid dihydrochloride
US6262057B1 (en) 1997-11-26 2001-07-17 Ucb, S.A. Pseudopolymorphic forms of 2-[2-[4-[Bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
US6335331B2 (en) 1997-11-26 2002-01-01 Ucb, S.A. Pseudopolymorphic forms of 2-[2-[4-[Bis (4-fluorophenyl) methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride

Also Published As

Publication number Publication date
JPS4942517B1 (en) 1974-11-15
ES337123A1 (en) 1968-01-16
CH505116A (en) 1971-03-31

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Legal Events

Date Code Title Description
414F Notice of opposition given (sect. 14/1949)
414A Case decided by the comptroller ** specification amended (sect. 14/1949)
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees