GB1223881A - Method of synthesis of 5-benzyl pyrimidine derivatives - Google Patents
Method of synthesis of 5-benzyl pyrimidine derivativesInfo
- Publication number
- GB1223881A GB1223881A GB524668A GB524668A GB1223881A GB 1223881 A GB1223881 A GB 1223881A GB 524668 A GB524668 A GB 524668A GB 524668 A GB524668 A GB 524668A GB 1223881 A GB1223881 A GB 1223881A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- synthesis
- benzyl
- pyrimidine derivatives
- feb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1,223,881. 2,4 - Diamino - 5 - (substituted benzyl)-pyrimidines. WELLCOME FOUNDATION Ltd. 1 Feb., 1968 [2 Feb., 1967], No. 5246/68. Heading C2C. [Also in Division A5] Compounds of formula wherein Z is H or C 1-4 alkyl, R<SP>2</SP>, R<SP>3</SP> are each halogen, or C 1-4 alkyl or alkoxy; and R<SP>1</SP> is C 1-10 alkyl, C 1-4 haloalkyl, an unsaturated C 2-4 aliphatic hydrocarbon radical, or benzyl possibly substituted by C 1-4 alkyl or alkoxy groups, are prepared by etherification of the corrsponding starting material, where R<SP>1</SP> = H, with R<SP>1</SP>Q (Q being a reactive atom or group) under basic conditions.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61345067A | 1967-02-02 | 1967-02-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1223881A true GB1223881A (en) | 1971-03-03 |
Family
ID=24457367
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB524668A Expired GB1223881A (en) | 1967-02-02 | 1968-02-01 | Method of synthesis of 5-benzyl pyrimidine derivatives |
GB4951470A Expired GB1223882A (en) | 1967-02-02 | 1968-02-01 | 5-benzylpyrimidine derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4951470A Expired GB1223882A (en) | 1967-02-02 | 1968-02-01 | 5-benzylpyrimidine derivatives |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE710100A (en) |
ES (1) | ES350062A1 (en) |
GB (2) | GB1223881A (en) |
IE (1) | IE32312B1 (en) |
NL (1) | NL6801540A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2249532A1 (en) * | 1971-10-12 | 1973-04-26 | Wellcome Found | PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPYRIMIDINES |
US4180578A (en) | 1977-05-09 | 1979-12-25 | Ludwig Heumann, & Co. GmbH | 2,4-Diamino-5-(4'-methylthio)benzylpyrimidenes, compounds, compositions and method of use |
JPS5536662B1 (en) * | 1970-10-22 | 1980-09-22 | ||
EP0054756A2 (en) * | 1980-11-27 | 1982-06-30 | The Wellcome Foundation Limited | Antibacterial benzylpyrimidines |
-
1968
- 1968-01-30 BE BE710100D patent/BE710100A/xx not_active IP Right Cessation
- 1968-02-01 ES ES350062A patent/ES350062A1/en not_active Expired
- 1968-02-01 GB GB524668A patent/GB1223881A/en not_active Expired
- 1968-02-01 GB GB4951470A patent/GB1223882A/en not_active Expired
- 1968-02-02 NL NL6801540A patent/NL6801540A/xx unknown
- 1968-02-02 IE IE13668A patent/IE32312B1/en unknown
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5536662B1 (en) * | 1970-10-22 | 1980-09-22 | ||
DE2249532A1 (en) * | 1971-10-12 | 1973-04-26 | Wellcome Found | PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPYRIMIDINES |
US4180578A (en) | 1977-05-09 | 1979-12-25 | Ludwig Heumann, & Co. GmbH | 2,4-Diamino-5-(4'-methylthio)benzylpyrimidenes, compounds, compositions and method of use |
EP0054756A2 (en) * | 1980-11-27 | 1982-06-30 | The Wellcome Foundation Limited | Antibacterial benzylpyrimidines |
EP0054756B1 (en) * | 1980-11-27 | 1986-07-23 | The Wellcome Foundation Limited | Antibacterial benzylpyrimidines |
Also Published As
Publication number | Publication date |
---|---|
BE710100A (en) | 1968-07-30 |
GB1223882A (en) | 1971-03-03 |
IE32312B1 (en) | 1973-06-27 |
IE32312L (en) | 1968-08-02 |
NL6801540A (en) | 1968-08-05 |
ES350062A1 (en) | 1969-11-16 |
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