GB1497265A - Pregnan-21-oic acid derivatives and the use and manufacture of pregnan-21-oic acid derivatives - Google Patents
Pregnan-21-oic acid derivatives and the use and manufacture of pregnan-21-oic acid derivativesInfo
- Publication number
- GB1497265A GB1497265A GB55527/74A GB5552774A GB1497265A GB 1497265 A GB1497265 A GB 1497265A GB 55527/74 A GB55527/74 A GB 55527/74A GB 5552774 A GB5552774 A GB 5552774A GB 1497265 A GB1497265 A GB 1497265A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steroids
- pregnan
- hydroxy
- oxidation
- oic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GWZUYOSMTQIJMY-DIKHCDEOSA-N 2-[(8s,9s,10s,13r,14s,17r)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]acetic acid Chemical class C1CCC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)CC(O)=O)[C@@H]4[C@@H]3CCC21 GWZUYOSMTQIJMY-DIKHCDEOSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003431 steroids Chemical class 0.000 abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 abstract 4
- 230000003647 oxidation Effects 0.000 abstract 4
- 238000007254 oxidation reaction Methods 0.000 abstract 4
- -1 methylene, carbonyl Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002573 ethenylidene group Chemical group [*]=C=C([H])[H] 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002373 hemiacetals Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0095—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 carbon in position 21 is part of carboxylic group
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2365102A DE2365102C2 (de) | 1973-12-21 | 1973-12-21 | Neue Pregnansäure-Derivate |
| DE19742441284 DE2441284C2 (de) | 1973-12-21 | 1974-08-27 | Verfahren zur Herstellung von Pregnansäure-Derivaten |
| DE19742444618 DE2444618C2 (de) | 1974-09-16 | 1974-09-16 | Neue Pregnan-21-säure-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1497265A true GB1497265A (en) | 1978-01-05 |
Family
ID=27185702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB55527/74A Expired GB1497265A (en) | 1973-12-21 | 1974-12-23 | Pregnan-21-oic acid derivatives and the use and manufacture of pregnan-21-oic acid derivatives |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US3944577A (cg-RX-API-DMAC10.html) |
| JP (1) | JPS5840559B2 (cg-RX-API-DMAC10.html) |
| AT (2) | AT347612B (cg-RX-API-DMAC10.html) |
| AU (1) | AU496759B2 (cg-RX-API-DMAC10.html) |
| BE (1) | BE823682A (cg-RX-API-DMAC10.html) |
| CA (1) | CA1060885A (cg-RX-API-DMAC10.html) |
| CH (1) | CH612688A5 (cg-RX-API-DMAC10.html) |
| DD (1) | DD119586A5 (cg-RX-API-DMAC10.html) |
| DK (1) | DK139361C (cg-RX-API-DMAC10.html) |
| EG (1) | EG11731A (cg-RX-API-DMAC10.html) |
| ES (1) | ES433216A1 (cg-RX-API-DMAC10.html) |
| FI (1) | FI53708C (cg-RX-API-DMAC10.html) |
| FR (1) | FR2255079B1 (cg-RX-API-DMAC10.html) |
| GB (1) | GB1497265A (cg-RX-API-DMAC10.html) |
| IE (1) | IE40456B1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL46296A (cg-RX-API-DMAC10.html) |
| IT (1) | IT1043908B (cg-RX-API-DMAC10.html) |
| NL (1) | NL7416805A (cg-RX-API-DMAC10.html) |
| NO (1) | NO744623L (cg-RX-API-DMAC10.html) |
| PH (1) | PH11030A (cg-RX-API-DMAC10.html) |
| SE (1) | SE410607B (cg-RX-API-DMAC10.html) |
| YU (1) | YU338574A (cg-RX-API-DMAC10.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4039668A (en) * | 1973-06-23 | 1977-08-02 | Schering Aktiengesellschaft | Corticoid-containing inhalants |
| DK118776A (da) * | 1975-03-21 | 1976-09-22 | Schering Ag | Pregnansyrederivater |
| US4181720A (en) * | 1978-04-05 | 1980-01-01 | Syntex (U.S.A.) Inc. | Corticosteroid antiinflammatory agents |
| US4257969A (en) * | 1980-01-23 | 1981-03-24 | E. R. Squibb & Sons, Inc. | 16,17-Dihydroxypregnene-21-carboxylic acids and derivatives |
| US4588530A (en) * | 1982-07-30 | 1986-05-13 | Florida Agricultural And Mechanical University | Anti-inflammatory prednisolone steroids |
| US4511511A (en) * | 1982-12-15 | 1985-04-16 | Crozer-Chester Medical Center | Prednisolone derivatives |
| US4897260A (en) * | 1987-05-22 | 1990-01-30 | The Rockefeller University | Compositions that affect suppression of cutaneous delayed hypersensitivity and products including same |
| JP3176075B2 (ja) * | 1991-03-04 | 2001-06-11 | 帝國製薬株式会社 | 新規なステロイド誘導体 |
| BR0213100A (pt) * | 2001-10-05 | 2004-11-30 | Combinatorx Inc | Combinações para o tratamento de distúrbios imuniinflamatórios |
| TW200517114A (en) * | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
| MX2008014828A (es) * | 2006-05-22 | 2009-02-06 | Combinatorx Inc | Metodos y composiciones para el tratamiento de enfermedades o condiciones asociadas con niveles incrementados de proteina c-reactiva, interleucina-6 o interferon-gamma. |
| CA2737131A1 (en) * | 2007-09-19 | 2009-03-26 | Zalicus Inc. | Therapeutic regimens for the treatment of immunoinflammatory disorders |
| CA2709561A1 (en) * | 2007-12-17 | 2009-06-25 | Combinatorx, Incorporated | Therapeutic regimens for the treatment of immunoinflammatory disorders |
| JP7330718B2 (ja) | 2019-02-28 | 2023-08-22 | 三菱重工業株式会社 | ガスタービンプラント、及びその排出二酸化炭素回収方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3833563A (en) * | 1971-10-04 | 1974-09-03 | Schering Ag | Novel pregnanoic acid derivatives |
| US3828080A (en) * | 1972-01-20 | 1974-08-06 | Glaxo Lab Ltd | Androstane-17beta-carboxylic acids and processes for the preparation thereof |
| DE2260303C2 (de) * | 1972-12-06 | 1983-12-15 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur Herstellung von Pregnansäurederivaten |
-
1974
- 1974-12-18 DD DD183151A patent/DD119586A5/xx unknown
- 1974-12-18 AU AU76585/74A patent/AU496759B2/en not_active Expired
- 1974-12-19 DK DK667574A patent/DK139361C/da not_active IP Right Cessation
- 1974-12-19 US US05/534,482 patent/US3944577A/en not_active Expired - Lifetime
- 1974-12-19 IE IE2620/74A patent/IE40456B1/xx unknown
- 1974-12-19 YU YU03385/74A patent/YU338574A/xx unknown
- 1974-12-19 SE SE7416038A patent/SE410607B/xx not_active IP Right Cessation
- 1974-12-20 IT IT7430860A patent/IT1043908B/it active
- 1974-12-20 CH CH1709774A patent/CH612688A5/xx not_active IP Right Cessation
- 1974-12-20 NO NO744623A patent/NO744623L/no unknown
- 1974-12-20 PH PH16647A patent/PH11030A/en unknown
- 1974-12-20 AT AT1021774A patent/AT347612B/de not_active IP Right Cessation
- 1974-12-20 FI FI3707/74A patent/FI53708C/fi active
- 1974-12-20 BE BE151786A patent/BE823682A/xx not_active IP Right Cessation
- 1974-12-20 IL IL46296A patent/IL46296A/xx unknown
- 1974-12-20 ES ES433216A patent/ES433216A1/es not_active Expired
- 1974-12-21 JP JP49147505A patent/JPS5840559B2/ja not_active Expired
- 1974-12-21 EG EG574A patent/EG11731A/xx active
- 1974-12-23 CA CA216,652A patent/CA1060885A/en not_active Expired
- 1974-12-23 NL NL7416805A patent/NL7416805A/xx not_active Application Discontinuation
- 1974-12-23 FR FR7442586A patent/FR2255079B1/fr not_active Expired
- 1974-12-23 GB GB55527/74A patent/GB1497265A/en not_active Expired
-
1978
- 1978-06-01 AT AT398978A patent/AT355744B/de not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |