ES2002923A6 - Procedimiento para preparar 4-hidroxi-2-oxo-pirrolidin-1-il-acetamida. - Google Patents

Procedimiento para preparar 4-hidroxi-2-oxo-pirrolidin-1-il-acetamida.

Info

Publication number
ES2002923A6
ES2002923A6 ES8603170A ES8603170A ES2002923A6 ES 2002923 A6 ES2002923 A6 ES 2002923A6 ES 8603170 A ES8603170 A ES 8603170A ES 8603170 A ES8603170 A ES 8603170A ES 2002923 A6 ES2002923 A6 ES 2002923A6
Authority
ES
Spain
Prior art keywords
alkoxy
pyrrolidin
oxo
alkyl
acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8603170A
Other languages
English (en)
Inventor
Thomas Meul
John Mcgarrity
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of ES2002923A6 publication Critical patent/ES2002923A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 4-HIDROXI-2-OXO-PIRROLIDIN-1-IL-ACETAMIDA, EN EL QUE SE HIDROGENA CON HIDROGENO, EN PRESENCIA DE UN CATALIZADOR DE HIDROGENACION, UN ESTER ALQUILICO C1-C4 DE ACIDO 4-ALCOXI-3-PIRROLIDIN-2-ON-1-IL-ACETICO, SE HACE REACCIONAR EL ESTER ALQUILICO C1-C4 DE ACIDO 4-ALCOXI-2-OXO-PIRROLIDIN-1-IL-ACETICO RESULTANTE CON TRICLOROMERILSILANO EN PRESENCIA DE UN YODURO DE METAL ALCALINO Y UN NITRILO DE ACIDO CARBOXILICO INFERIOR COMO DISOLVENTE, PARA DAR ESTER ALQUILICO C1-C4 DE ACIDO 4-HIDROXI-2-OXO-PIRROLIDIN-1-IL-ACETICO, Y FINALMENTE, EN UNA ULTIMA ETAPA, SE HACE REACCIONAR DICHO ESTER CON AMONIACO PARA PROPORCIONAR EL PRODUCTO FINAL. EL COMPUESTO OBTENIDO ES UTIL POR SU ACTIVIDAD SOBRE EL CEREBRO.
ES8603170A 1985-11-26 1986-11-25 Procedimiento para preparar 4-hidroxi-2-oxo-pirrolidin-1-il-acetamida. Expired ES2002923A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH5036/85A CH666891A5 (de) 1985-11-26 1985-11-26 4-alkoxy-2-oxo-pyrrolidin-1-yl-essigsaeure-c(1)-c(4)-alkylester, deren herstellung und verwendung.

Publications (1)

Publication Number Publication Date
ES2002923A6 true ES2002923A6 (es) 1988-10-01

Family

ID=4286858

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8603170A Expired ES2002923A6 (es) 1985-11-26 1986-11-25 Procedimiento para preparar 4-hidroxi-2-oxo-pirrolidin-1-il-acetamida.

Country Status (9)

Country Link
EP (1) EP0224256A1 (es)
JP (1) JPS62126164A (es)
CH (1) CH666891A5 (es)
DK (1) DK564786A (es)
ES (1) ES2002923A6 (es)
HU (1) HU196176B (es)
IL (1) IL80656A0 (es)
NO (1) NO864719D0 (es)
SU (1) SU1486056A3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1215590B (it) * 1987-06-29 1990-02-14 Roussel Maestretti Spa Derivati della 1-benzene solfonil 2-oco 5-alchiltio pirrolidina, un loro procedimentodi preparazione e il loro impiegocome stostanze medicinali.
CH680293A5 (es) * 1990-06-26 1992-07-31 Lonza Ag
GB0004297D0 (en) * 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
CN102924357A (zh) * 2011-08-09 2013-02-13 重庆圣华曦药业股份有限公司 奥拉西坦中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1075280B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
CH647234A5 (en) * 1981-07-24 1985-01-15 Hoffmann La Roche Pyrrolidine derivatives
IT1206699B (it) * 1984-02-27 1989-04-27 Isf Spa Procedimento per preparare derivati di pirrolidone.

Also Published As

Publication number Publication date
DK564786A (da) 1987-05-27
NO864719D0 (no) 1986-11-25
HU196176B (en) 1988-10-28
SU1486056A3 (ru) 1989-06-07
JPS62126164A (ja) 1987-06-08
EP0224256A1 (de) 1987-06-03
IL80656A0 (en) 1987-02-27
CH666891A5 (de) 1988-08-31
HUT42438A (en) 1987-07-28
DK564786D0 (da) 1986-11-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000202