ES8606356A1 - Procedimiento para preparar noroximorfona a partir de morfi-na - Google Patents

Procedimiento para preparar noroximorfona a partir de morfi-na

Info

Publication number
ES8606356A1
ES8606356A1 ES541631A ES541631A ES8606356A1 ES 8606356 A1 ES8606356 A1 ES 8606356A1 ES 541631 A ES541631 A ES 541631A ES 541631 A ES541631 A ES 541631A ES 8606356 A1 ES8606356 A1 ES 8606356A1
Authority
ES
Spain
Prior art keywords
diethoxycarbonyl
normorphinone
noroxymorphone
novel
converted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541631A
Other languages
English (en)
Other versions
ES541631A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of ES8606356A1 publication Critical patent/ES8606356A1/es
Publication of ES541631A0 publication Critical patent/ES541631A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NOROXIMORFONA A PARTIR DE MORFINA. COMPRENDE: A) TRATAR A LA MORFINA CON UN ESTER HALOFORMATO DE FORMULA (X-C(FO)OR1, ENTRE 40JC Y 120JC, PARA OBTENER A (II); B) OXIDAR A (II) CON TRIOXIDO DE CROMO ENTRE 0J Y 25JC, PARA REALIZAR (III); C) ACILAR A (III) CON UN ANHIDRIDO DE ACIDO DE FORMULA (R2)2O O UN HALURO DE ACILO DE FORMULA (R2X), ENTRE 100 Y 105JC, PARA PRODUCIR (IV); D) OXIDAR A (IV) CON PERACIDO CARBOXILICO AROMATICO, ENTRE 10JC Y 100JC, PARA FORMAR (V), E) HIDROGENAR A (V), EN PRESENCIA DE PD/C, RD/C Y ENTRE 25J Y 80JC, PARA CONSEGUIR A (VI) Y F) HIDROLIZAR A (VI) CON ACIDO METANOSULFONICO, EN PRESENCIA DE SO4H28N Y ENTRE 90J Y 100JC, PARA OBTENER A (I). SIENDO: R1 Y R2 ALQUILO, ALQUENILO Y OTROS; R2 Y X HAL. SE UTILIZAN COMO ANALGESICOS.
ES541631A 1984-03-27 1985-03-27 Procedimiento para preparar noroximorfona a partir de morfi-na Expired ES8606356A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59374484A 1984-03-27 1984-03-27
US71393285A 1985-03-10 1985-03-10

Publications (2)

Publication Number Publication Date
ES8606356A1 true ES8606356A1 (es) 1986-04-01
ES541631A0 ES541631A0 (es) 1986-04-01

Family

ID=27081787

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541631A Expired ES8606356A1 (es) 1984-03-27 1985-03-27 Procedimiento para preparar noroximorfona a partir de morfi-na

Country Status (6)

Country Link
EP (1) EP0158476B1 (es)
JP (1) JPH0651705B2 (es)
DE (1) DE3581423D1 (es)
ES (1) ES8606356A1 (es)
FR (1) FR2562072B1 (es)
IT (1) IT1199871B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
BRPI0211899B8 (pt) 2001-08-23 2021-05-25 Akzo Nobel Nv processos para a preparação de um derivado de 14- hidroxinormorfinona e para a produção de noroximorfona
WO2006084389A1 (de) 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
JP2008546688A (ja) * 2005-06-16 2008-12-25 マリンクロッド・インコーポレイテッド １−ハロ−テバインまたは類似体を介する１４−ヒドロキシルオピエート類への合成経路
US8067596B2 (en) 2007-12-17 2011-11-29 Mallinckrodt Llc Processes for the production of (+)- “Nal” morphinan compounds
PL2222642T3 (pl) * 2007-12-17 2014-07-31 SpecGx LLC Sposób i związki do wytwarzania (+) opiatów
NZ586186A (en) * 2007-12-17 2012-08-31 Mallinckrodt Llc Processes for the preparation of normorphinan salts
CA2709862C (en) * 2007-12-17 2016-03-15 Peter X. Wang Sinomenine derivatives and processes for their synthesis
WO2009122436A2 (en) * 2008-03-31 2009-10-08 Sun Pharmaceutical Industries Ltd. An improved process for the preparation of morphinane analogues
PL2896614T3 (pl) * 2008-05-27 2018-02-28 Mallinckrodt Llc Sposoby i związki do wytwarzania normorfinanów
AU2011263417B2 (en) 2010-06-11 2014-03-27 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
KR20140063763A (ko) 2011-09-08 2014-05-27 말린크로트 엘엘씨 중간체를 단리하지 않는 알칼로이드의 제조 방법
EP2829541A1 (en) 2013-07-26 2015-01-28 Siegfried AG Novel synthesis of noroxymorphone from morphine
CN104230945B (zh) * 2014-08-23 2016-05-18 成都天台山制药有限公司 盐酸纳洛酮的合成方法
KR20230127222A9 (ko) * 2020-12-28 2024-03-25 나빈 삭세나 리서치 앤드 테크놀로지 피브이티. 엘티디. 모르핀으로부터 노르옥시모르폰의 합성을 위한 신규의 제조방법
US11247999B1 (en) 2021-07-02 2022-02-15 Joseph DeGraw Facile conversion of morphine to normorphine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE408870C (de) * 1923-09-11 1925-01-24 Merck Chem Fab E Verfahren zur Darstellung von Kodeienon
DE1938219A1 (de) * 1968-07-26 1970-02-12 Sankyo Co Verfahren zur Herstellung von 14-Hydroxy-normorphinonderivaten
DE2727805A1 (de) * 1977-06-21 1979-01-04 Goedecke Ag Verfahren zur herstellung von oxynormorphon
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative

Also Published As

Publication number Publication date
DE3581423D1 (de) 1991-02-28
EP0158476B1 (en) 1991-01-23
FR2562072A1 (fr) 1985-10-04
IT8567297A0 (it) 1985-03-26
IT1199871B (it) 1989-01-05
IT8567297A1 (it) 1986-09-26
JPH0651705B2 (ja) 1994-07-06
FR2562072B1 (fr) 1989-07-07
JPS60252481A (ja) 1985-12-13
EP0158476A1 (en) 1985-10-16
ES541631A0 (es) 1986-04-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050829