IT8567297A1 - Procedimento per la preparazione di norossimorfone dalla morfina e nuovi composti intermedi per tale procedimento. - Google Patents
Procedimento per la preparazione di norossimorfone dalla morfina e nuovi composti intermedi per tale procedimento.Info
- Publication number
- IT8567297A1 IT8567297A1 IT1985A67297A IT6729785A IT8567297A1 IT 8567297 A1 IT8567297 A1 IT 8567297A1 IT 1985A67297 A IT1985A67297 A IT 1985A67297A IT 6729785 A IT6729785 A IT 6729785A IT 8567297 A1 IT8567297 A1 IT 8567297A1
- Authority
- IT
- Italy
- Prior art keywords
- noroxymorphone
- morphine
- preparation
- new intermediates
- intermediates
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title 2
- HLMSIZPQBSYUNL-IPOQPSJVSA-N Noroxymorphone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4 HLMSIZPQBSYUNL-IPOQPSJVSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 229960005181 morphine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59374484A | 1984-03-27 | 1984-03-27 | |
US71393285A | 1985-03-20 | 1985-03-20 |
Publications (3)
Publication Number | Publication Date |
---|---|
IT8567297A0 IT8567297A0 (it) | 1985-03-26 |
IT8567297A1 true IT8567297A1 (it) | 1986-09-26 |
IT1199871B IT1199871B (it) | 1989-01-05 |
Family
ID=27081787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT67297/85A IT1199871B (it) | 1984-03-27 | 1985-03-26 | Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0158476B1 (it) |
JP (1) | JPH0651705B2 (it) |
DE (1) | DE3581423D1 (it) |
ES (1) | ES8606356A1 (it) |
FR (1) | FR2562072B1 (it) |
IT (1) | IT1199871B (it) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4795813A (en) * | 1981-08-17 | 1989-01-03 | The Florida Board Of Regents On Behalf Of The Florida State University | Synthesis of derivatives of codeine and other 3-O-alkylmorphines |
US5668285A (en) * | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
WO2003018588A2 (en) | 2001-08-23 | 2003-03-06 | Akzo Nobel N.V. | Process for the preparation of a 14-hydroxynormorphinone derivative |
WO2006084389A1 (de) | 2005-02-11 | 2006-08-17 | Cilag Ltd. | Verfahren zur reinigung von noroxymorphon-verbindungen |
CA2610859C (en) * | 2005-06-16 | 2013-11-12 | Peter Xianqi Wang | A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs |
CA2709886C (en) * | 2007-12-17 | 2016-10-25 | Mallinckrodt Inc. | Processes for the production of (+)-"nal" morphinan compounds |
EP2231674A1 (en) * | 2007-12-17 | 2010-09-29 | Mallinckrodt Inc. | Processes for the preparation of normorphinan salts |
CA2709858C (en) * | 2007-12-17 | 2016-03-29 | Peter X. Wang | Process and compounds for the production of (+)opiates |
NZ586187A (en) * | 2007-12-17 | 2013-07-26 | Mallinckrodt Llc | Processes for the synthesis of sinomenine derivatives and their intermediate |
AU2009233315B2 (en) * | 2008-03-31 | 2013-08-29 | Sun Pharmaceutical Industries Ltd. | An improved process for the preparation of morphinane analogues |
ES2641887T3 (es) * | 2008-05-27 | 2017-11-14 | Mallinckrodt Llc | Procesos y compuestos para la preparación de normorfinanos |
EP2995614B8 (en) | 2010-06-11 | 2018-03-28 | Rhodes Technologies Inc. | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
JP2014526467A (ja) | 2011-09-08 | 2014-10-06 | マリンクロッド エルエルシー | 中間体の単離なしでのアルカロイドの調製 |
EP2829541A1 (en) | 2013-07-26 | 2015-01-28 | Siegfried AG | Novel synthesis of noroxymorphone from morphine |
CN104230945B (zh) * | 2014-08-23 | 2016-05-18 | 成都天台山制药有限公司 | 盐酸纳洛酮的合成方法 |
BR112023012708A2 (pt) * | 2020-12-28 | 2023-10-03 | Navin Saxena Research & Tech Pvt Ltd | Processo para síntese de noroximorfona a partir da morfina |
US11247999B1 (en) | 2021-07-02 | 2022-02-15 | Joseph DeGraw | Facile conversion of morphine to normorphine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE408870C (de) * | 1923-09-11 | 1925-01-24 | Merck Chem Fab E | Verfahren zur Darstellung von Kodeienon |
DE1938219A1 (de) * | 1968-07-26 | 1970-02-12 | Sankyo Co | Verfahren zur Herstellung von 14-Hydroxy-normorphinonderivaten |
DE2727805A1 (de) * | 1977-06-21 | 1979-01-04 | Goedecke Ag | Verfahren zur herstellung von oxynormorphon |
US4472253A (en) * | 1981-08-17 | 1984-09-18 | The Florida Board Of Regents On Behalf Of The Florida State University | Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative |
-
1985
- 1985-03-26 FR FR858504487A patent/FR2562072B1/fr not_active Expired
- 1985-03-26 EP EP85302103A patent/EP0158476B1/en not_active Expired - Lifetime
- 1985-03-26 IT IT67297/85A patent/IT1199871B/it active
- 1985-03-26 DE DE8585302103T patent/DE3581423D1/de not_active Expired - Lifetime
- 1985-03-27 ES ES541631A patent/ES8606356A1/es not_active Expired
- 1985-03-27 JP JP60061024A patent/JPH0651705B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES8606356A1 (es) | 1986-04-01 |
JPS60252481A (ja) | 1985-12-13 |
ES541631A0 (es) | 1986-04-01 |
FR2562072A1 (fr) | 1985-10-04 |
IT8567297A0 (it) | 1985-03-26 |
FR2562072B1 (fr) | 1989-07-07 |
EP0158476A1 (en) | 1985-10-16 |
DE3581423D1 (de) | 1991-02-28 |
EP0158476B1 (en) | 1991-01-23 |
IT1199871B (it) | 1989-01-05 |
JPH0651705B2 (ja) | 1994-07-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19980327 |