GB1486557A - Process for the preparation of pyrogen-free sub-unit vaccine - Google Patents

Process for the preparation of pyrogen-free sub-unit vaccine

Info

Publication number
GB1486557A
GB1486557A GB48685/73A GB4868573A GB1486557A GB 1486557 A GB1486557 A GB 1486557A GB 48685/73 A GB48685/73 A GB 48685/73A GB 4868573 A GB4868573 A GB 4868573A GB 1486557 A GB1486557 A GB 1486557A
Authority
GB
United Kingdom
Prior art keywords
active agent
density gradient
pyrogen
preparation
free sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB48685/73A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flockhart & Co
Original Assignee
Flockhart & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flockhart & Co filed Critical Flockhart & Co
Priority to GB48685/73A priority Critical patent/GB1486557A/en
Priority to ZA00746398A priority patent/ZA746398B/xx
Priority to DK543974AA priority patent/DK138581B/da
Priority to JP49119836A priority patent/JPS5082228A/ja
Priority to AT835074A priority patent/AT334524B/de
Priority to BE149618A priority patent/BE821175A/xx
Priority to NLAANVRAGE7413642,A priority patent/NL181553C/xx
Priority to IL45870A priority patent/IL45870A/xx
Priority to CH1394974A priority patent/CH611518A5/xx
Priority to SE7413113A priority patent/SE426439B/xx
Priority to NO743758A priority patent/NO142024C/no
Priority to DE2449530A priority patent/DE2449530C2/de
Priority to CA211,654A priority patent/CA1050886A/en
Priority to AU74449/74A priority patent/AU494738B2/en
Priority to IE2141/74A priority patent/IE40187B1/xx
Priority to FR7435179A priority patent/FR2248054B1/fr
Publication of GB1486557A publication Critical patent/GB1486557A/en
Priority to US05/879,386 priority patent/US4158054A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17—Newcastle disease virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16251—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18151—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GB48685/73A 1973-10-18 1973-10-18 Process for the preparation of pyrogen-free sub-unit vaccine Expired GB1486557A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
GB48685/73A GB1486557A (en) 1973-10-18 1973-10-18 Process for the preparation of pyrogen-free sub-unit vaccine
ZA00746398A ZA746398B (en) 1973-10-18 1974-10-08 Preparation of vaccines
SE7413113A SE426439B (sv) 1973-10-18 1974-10-17 Sett att framstella virusvaccin i vilket ingar fragment av eterkenligt virus
DE2449530A DE2449530C2 (de) 1973-10-18 1974-10-17 Virusuntereinheitenimpfstoff
AT835074A AT334524B (de) 1973-10-18 1974-10-17 Verfahren zur herstellung einer virus-untereinheiten-vaccine
BE149618A BE821175A (fr) 1973-10-18 1974-10-17 Preparation de vaccins a fragments de virus apyretogenes
NLAANVRAGE7413642,A NL181553C (nl) 1973-10-18 1974-10-17 Werkwijze voor de bereiding van een virus-subeenheid-vaccin.
IL45870A IL45870A (en) 1973-10-18 1974-10-17 Process for preparation of vaccines
CH1394974A CH611518A5 (en) 1973-10-18 1974-10-17 Process for the preparation of a virus subunit vaccine
DK543974AA DK138581B (da) 1973-10-18 1974-10-17 Fremgangsmåde til fremstilling af en virus-underenhedsvaccine stammende fra et æterfølsomt virus.
NO743758A NO142024C (no) 1973-10-18 1974-10-17 Fremgangsmaate for fremstilling av en vaksine, saerlig influensavaksine, ved aa dyrke et virus
JP49119836A JPS5082228A (no) 1973-10-18 1974-10-17
CA211,654A CA1050886A (en) 1973-10-18 1974-10-17 Preparation of pyrogen free virus sub-unit vaccines
AU74449/74A AU494738B2 (en) 1974-10-18 1974-10-17 Virus subunit vaccine
IE2141/74A IE40187B1 (en) 1973-10-18 1974-10-17 Process for the preparation of pyrogen-free sub-unit vaccine
FR7435179A FR2248054B1 (no) 1973-10-18 1974-10-18
US05/879,386 US4158054A (en) 1973-10-18 1978-02-21 Preparation of virus sub-unit vaccines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB48685/73A GB1486557A (en) 1973-10-18 1973-10-18 Process for the preparation of pyrogen-free sub-unit vaccine

Publications (1)

Publication Number Publication Date
GB1486557A true GB1486557A (en) 1977-09-21

Family

ID=10449549

Family Applications (1)

Application Number Title Priority Date Filing Date
GB48685/73A Expired GB1486557A (en) 1973-10-18 1973-10-18 Process for the preparation of pyrogen-free sub-unit vaccine

Country Status (15)

Country Link
JP (1) JPS5082228A (no)
AT (1) AT334524B (no)
BE (1) BE821175A (no)
CA (1) CA1050886A (no)
CH (1) CH611518A5 (no)
DE (1) DE2449530C2 (no)
DK (1) DK138581B (no)
FR (1) FR2248054B1 (no)
GB (1) GB1486557A (no)
IE (1) IE40187B1 (no)
IL (1) IL45870A (no)
NL (1) NL181553C (no)
NO (1) NO142024C (no)
SE (1) SE426439B (no)
ZA (1) ZA746398B (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002028426A1 (en) * 2000-10-02 2002-04-11 Glaxosmithkline Biologicals S.A. Split enveloped virus preparation

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK276380A (da) * 1979-07-09 1981-01-10 Univ Iowa State Res Found Inc Fremgangsmaade til fremstilling af en vaccine mod infektioes kvaeg-rhinotracheitis
FR2470795A1 (fr) * 1979-12-07 1981-06-12 Pasteur Institut Procede de purification de particules d'origine biologique, notamment de l'antigene de surface du virus de l'hepatite b (aghbs) et les produits obtenus
FR2475572A1 (fr) * 1980-02-11 1981-08-14 Pasteur Institut Procede pour l'obtention de fragments de virus a enveloppe lipidique, en particulier d'antigenes utilisables comme vaccins, produits obtenus et applications
FR2483779A1 (fr) 1980-06-05 1981-12-11 Synthelabo Procede pour isoler des antigenes glycoproteiques viraux et son application a la preparation de vaccins
DE19938767C2 (de) * 1999-08-16 2002-10-24 Tad Pharma Gmbh Spaltimpfstoffe

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3519400A (en) * 1967-01-25 1970-07-07 Atomic Energy Commission Method of centrifugal separation and recovery of chemical species utilizing a liquid medium

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002028426A1 (en) * 2000-10-02 2002-04-11 Glaxosmithkline Biologicals S.A. Split enveloped virus preparation

Also Published As

Publication number Publication date
CH611518A5 (en) 1979-06-15
DK138581B (da) 1978-10-02
IL45870A (en) 1978-03-10
IE40187B1 (en) 1979-03-28
DE2449530A1 (de) 1975-04-30
ATA835074A (de) 1976-05-15
DE2449530C2 (de) 1985-08-08
DK543974A (no) 1975-06-16
NL7413642A (nl) 1975-04-22
IL45870A0 (en) 1974-12-31
NO743758L (no) 1975-05-12
NO142024B (no) 1980-03-10
NL181553C (nl) 1987-09-16
FR2248054A1 (no) 1975-05-16
NL181553B (nl) 1987-04-16
SE7413113L (no) 1975-04-21
ZA746398B (en) 1976-06-30
AU7444974A (en) 1976-04-29
JPS5082228A (no) 1975-07-03
BE821175A (fr) 1975-04-17
IE40187L (en) 1975-04-18
DK138581C (no) 1979-03-12
FR2248054B1 (no) 1978-07-28
AT334524B (de) 1976-01-25
SE426439B (sv) 1983-01-24
NO142024C (no) 1980-06-18
CA1050886A (en) 1979-03-20

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19941016