GB1039722A - Process for the manufacture of a foot-and-mouth disease vaccine containing a live virus - Google Patents

Process for the manufacture of a foot-and-mouth disease vaccine containing a live virus

Info

Publication number
GB1039722A
GB1039722A GB20031/63A GB2003163A GB1039722A GB 1039722 A GB1039722 A GB 1039722A GB 20031/63 A GB20031/63 A GB 20031/63A GB 2003163 A GB2003163 A GB 2003163A GB 1039722 A GB1039722 A GB 1039722A
Authority
GB
United Kingdom
Prior art keywords
virus
foot
mouth disease
animal
pathogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20031/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of GB1039722A publication Critical patent/GB1039722A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/125Picornaviridae, e.g. calicivirus
    • A61K39/135Foot- and mouth-disease virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32111Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32111Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32151Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A foot-and-mouth disease vaccine containing live virus is prepared by subjecting a pathogenic foot-and-mouth disease virus to serial passage at 37 DEG C. through primary cell cultures containing Hank's or Earle's solution, lactalbumin hydrolysate, serum and cells obtained by the trypsinization of an organ of a hoofed animal until the said virus destroys a cell monolayer of one serial passage, and then continuing the serial passage through the same type primary cell cultures at 26 to 30 DEG C., and preferably 28 DEG C., until the virus is so modified that when parenterally injected into a hoofed animal, it is non-pathogenic towards the animal and produces in the animal an immunizing action similar to that of the pathogenic virus. In the example, calves serum and cells obtained from the kidneys of freshly slaughtered calves are used.
GB20031/63A 1962-05-18 1963-05-20 Process for the manufacture of a foot-and-mouth disease vaccine containing a live virus Expired GB1039722A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB67300A DE1174016B (en) 1962-05-18 1962-05-18 Process for the production of a live vaccine against foot and mouth disease

Publications (1)

Publication Number Publication Date
GB1039722A true GB1039722A (en) 1966-08-17

Family

ID=6975473

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20031/63A Expired GB1039722A (en) 1962-05-18 1963-05-20 Process for the manufacture of a foot-and-mouth disease vaccine containing a live virus

Country Status (3)

Country Link
BR (1) BR6349184D0 (en)
DE (1) DE1174016B (en)
GB (1) GB1039722A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2088038A1 (en) * 1970-05-11 1972-01-07 Bellon Labor Sa Roger
CN111184221A (en) * 2019-10-21 2020-05-22 青海宏健生物科技集团有限公司 Yak tendon collagen oral liquid and preparation method thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287178A (en) * 1974-03-25 1981-09-01 Pitman-Moore, Inc. Feline rhinotracheitis vaccine and production and use thereof
US4303645A (en) 1980-04-18 1981-12-01 Cornell Research Foundation, Inc. Modified living canine parvovirus vaccine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2088038A1 (en) * 1970-05-11 1972-01-07 Bellon Labor Sa Roger
CN111184221A (en) * 2019-10-21 2020-05-22 青海宏健生物科技集团有限公司 Yak tendon collagen oral liquid and preparation method thereof

Also Published As

Publication number Publication date
BR6349184D0 (en) 1973-08-02
DE1174016B (en) 1964-07-16

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