GB878704A - Propagation of attenuated infectious canine hepatitis virus in trypsinized tissue cultures of pig kidney and the preparation of a vaccine therefrom - Google Patents

Propagation of attenuated infectious canine hepatitis virus in trypsinized tissue cultures of pig kidney and the preparation of a vaccine therefrom

Info

Publication number
GB878704A
GB878704A GB8520/58A GB852058A GB878704A GB 878704 A GB878704 A GB 878704A GB 8520/58 A GB8520/58 A GB 8520/58A GB 852058 A GB852058 A GB 852058A GB 878704 A GB878704 A GB 878704A
Authority
GB
United Kingdom
Prior art keywords
vaccine
propagation
pig kidney
hepatitis virus
trypsinized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8520/58A
Inventor
Jerrell Bemis Emery
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALLIED LAB Inc
Original Assignee
ALLIED LAB Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALLIED LAB Inc filed Critical ALLIED LAB Inc
Priority to GB8520/58A priority Critical patent/GB878704A/en
Publication of GB878704A publication Critical patent/GB878704A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10361—Methods of inactivation or attenuation

Abstract

A vaccine is produced by attentuating canine hepatitis virus by a number of serial passages in trypsinized tissue culture of dog kidney, uterus or testicle, followed by propagation in a trypsinized pig kidney tissue culture in a medium which supports growth and/or maintenance of pig kidney cells, for example: 8 parts Earles solution, 1 part 5% lactalbumin hydrolysate and 1 part inactivated horse serum; 8 parts Earles-Simms solution, 1 part 5% lactalbumin hydrolysate and 1 part inactivated horse serum, or # 199 of Morgan, Morton and Parker supplemented with 10% inactivated horse serum. The virus containing liquid is harvested and may be used as a vaccine or be freeze-dried to give a solid which may be diluted with distilled water for use as a vaccine.
GB8520/58A 1958-03-17 1958-03-17 Propagation of attenuated infectious canine hepatitis virus in trypsinized tissue cultures of pig kidney and the preparation of a vaccine therefrom Expired GB878704A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB8520/58A GB878704A (en) 1958-03-17 1958-03-17 Propagation of attenuated infectious canine hepatitis virus in trypsinized tissue cultures of pig kidney and the preparation of a vaccine therefrom

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8520/58A GB878704A (en) 1958-03-17 1958-03-17 Propagation of attenuated infectious canine hepatitis virus in trypsinized tissue cultures of pig kidney and the preparation of a vaccine therefrom

Publications (1)

Publication Number Publication Date
GB878704A true GB878704A (en) 1961-10-04

Family

ID=9854015

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8520/58A Expired GB878704A (en) 1958-03-17 1958-03-17 Propagation of attenuated infectious canine hepatitis virus in trypsinized tissue cultures of pig kidney and the preparation of a vaccine therefrom

Country Status (1)

Country Link
GB (1) GB878704A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025745A1 (en) * 1979-09-04 1981-03-25 Merck & Co. Inc. Process for propagating human hepatitis A virus in in vitro cell culture
EP0074119A1 (en) * 1981-09-09 1983-03-16 Bertram Dr. Flehmig Hepatitis-A viruses adapted to human fibroblast cells
US5514376A (en) * 1979-09-04 1996-05-07 Merck & Co., Inc. Cell culture of hepatitis A virus

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025745A1 (en) * 1979-09-04 1981-03-25 Merck & Co. Inc. Process for propagating human hepatitis A virus in in vitro cell culture
US5514376A (en) * 1979-09-04 1996-05-07 Merck & Co., Inc. Cell culture of hepatitis A virus
US5766603A (en) * 1979-09-04 1998-06-16 Merck & Co., Inc. Cell culture of hepatitis A virus
EP0074119A1 (en) * 1981-09-09 1983-03-16 Bertram Dr. Flehmig Hepatitis-A viruses adapted to human fibroblast cells

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