GB1476214A - Dibenzoxepin derivatives process for the preparation thereof and pharmaceutical compositions containing them - Google Patents
Dibenzoxepin derivatives process for the preparation thereof and pharmaceutical compositions containing themInfo
- Publication number
- GB1476214A GB1476214A GB3258074A GB3258074A GB1476214A GB 1476214 A GB1476214 A GB 1476214A GB 3258074 A GB3258074 A GB 3258074A GB 3258074 A GB3258074 A GB 3258074A GB 1476214 A GB1476214 A GB 1476214A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- july
- carboxyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- APMCUORPNXHBQK-UHFFFAOYSA-N benzo[c][1]benzoxepine Chemical class O1C=C2C=CC=CC2=CC2=CC=CC=C12 APMCUORPNXHBQK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 230000001590 oxidative effect Effects 0.000 abstract 3
- WNZQDUSMALZDQF-UHFFFAOYSA-N 2-benzofuran-1(3H)-one Chemical compound C1=CC=C2C(=O)OCC2=C1 WNZQDUSMALZDQF-UHFFFAOYSA-N 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000005042 acyloxymethyl group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052804 chromium Inorganic materials 0.000 abstract 1
- 239000011651 chromium Substances 0.000 abstract 1
- KMPWYEUPVWOPIM-KODHJQJWSA-N cinchonidine Chemical compound C1=CC=C2C([C@H]([C@H]3[N@]4CC[C@H]([C@H](C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-KODHJQJWSA-N 0.000 abstract 1
- KMPWYEUPVWOPIM-UHFFFAOYSA-N cinchonidine Natural products C1=CC=C2C(C(C3N4CCC(C(C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000000911 decarboxylating effect Effects 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000004997 halocarbonyl group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000012286 potassium permanganate Substances 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
- C07C37/002—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8333673A JPS5516428B2 (ro) | 1973-07-24 | 1973-07-24 | |
| JP8374273A JPS558979B2 (ro) | 1973-07-25 | 1973-07-25 | |
| JP8443473A JPS5516429B2 (ro) | 1973-07-26 | 1973-07-26 | |
| JP1692674A JPS5724352B2 (ro) | 1974-02-12 | 1974-02-12 | |
| JP1692774A JPS50108281A (ro) | 1974-02-12 | 1974-02-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1476214A true GB1476214A (en) | 1977-06-10 |
Family
ID=27519864
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4007476A Expired GB1476215A (en) | 1973-07-24 | 1974-07-23 | Dibenzoxepin derivatives process for the preparation thereof and pharmaceutical compositions containing them |
| GB3258074A Expired GB1476214A (en) | 1973-07-24 | 1974-07-23 | Dibenzoxepin derivatives process for the preparation thereof and pharmaceutical compositions containing them |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4007476A Expired GB1476215A (en) | 1973-07-24 | 1974-07-23 | Dibenzoxepin derivatives process for the preparation thereof and pharmaceutical compositions containing them |
Country Status (11)
| Country | Link |
|---|---|
| AR (1) | AR210725A1 (ro) |
| BE (1) | BE818055A (ro) |
| CA (1) | CA1153383A (ro) |
| CH (6) | CH605896A5 (ro) |
| DE (1) | DE2435613B2 (ro) |
| DK (1) | DK396874A (ro) |
| FR (1) | FR2245356B1 (ro) |
| GB (2) | GB1476215A (ro) |
| NL (1) | NL159381B (ro) |
| SE (2) | SE7409577L (ro) |
| YU (5) | YU204274A (ro) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0003893A1 (en) * | 1978-02-17 | 1979-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel dibenz (b,f) oxepin and dibenzo (b,f) thiepin compounds and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions containing them |
| US4356186A (en) | 1980-03-31 | 1982-10-26 | Dainippon Pharmaceutical Co., Ltd. | Acetic acid derivatives and composition containing the same |
| US4526891A (en) * | 1983-03-10 | 1985-07-02 | Hoechst Roussel Pharmaceuticals Inc. | Substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins |
| US4576960A (en) * | 1981-12-23 | 1986-03-18 | Hoechst Roussel Pharmaceuticals Incorporated | 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin derivatives |
| CN106518833A (zh) * | 2015-09-15 | 2017-03-22 | 江苏吉贝尔药业股份有限公司 | 一种新的6，11-二氢-11-氧代二苯并［b，e］噁庚因-2-乙酸制备方法 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES444144A1 (es) * | 1975-01-14 | 1977-08-16 | Hoechst Ag | Un procedimiento para la preparacion de un acido 6,11-dihi- dro-11-oxo-dibenz (b, e) oxepin-alcanoico. |
| DE2600768C2 (de) * | 1975-02-04 | 1983-10-27 | Hoechst Ag, 6230 Frankfurt | Verfahren zur Herstellung von 6,11-Dihydro-11-oxodibenz[b,e]-oxepin-alkansäuren |
| DE2629569A1 (de) * | 1975-07-30 | 1977-03-31 | Hoechst Ag | 6,11-dihydro-11-oxodibenz eckige klammer auf b,e eckige klammer zu oxepin-alkansaeuren und deren ester sowie verfahren zu ihrer herstellung |
| US4082850A (en) | 1976-04-16 | 1978-04-04 | American Hoechst Corporation | Method of treating dermal inflammations |
| DE3125374A1 (de) * | 1981-06-27 | 1983-01-13 | Hoechst Ag, 6000 Frankfurt | Verfahren zur herstellung von heteroaryl- und dibenzoxepinalkansaeuren |
| US4515946A (en) * | 1981-12-23 | 1985-05-07 | Hoechst-Roussel Pharmaceuticals Inc. | 6,11-Dihydro-11-oxo-dibenz-[b,e]oxepin derivatives |
| US5008285A (en) * | 1984-04-27 | 1991-04-16 | Hoechst-Roussel Pharmaceuticals, Inc. | (6,11-dihydro-11-oxodibenz[b,e]oxepin-yl)pentanoic acids and derivatives thereof |
| ATE46693T1 (de) * | 1984-04-27 | 1989-10-15 | Hoechst Roussel Pharma | (6,11-dihydro-11-oxodibenz(b,e>oxepinyl)pentanole, verfahren und zwischenprodukte zu deren herstellung und deren verwendung als arzneimittel. |
| US4861887A (en) * | 1988-01-27 | 1989-08-29 | American Cyanamid Company | Herbicidal o-(substituted, aminomethylbenzoic, nicotinic and quinoline-3-carboxylic acids, esters, and salts |
| US7687646B2 (en) | 2006-03-28 | 2010-03-30 | Azad Pharmaceutical Ingredients, Ag | Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof |
-
1974
- 1974-07-22 YU YU02042/74A patent/YU204274A/xx unknown
- 1974-07-23 FR FR7425559A patent/FR2245356B1/fr not_active Expired
- 1974-07-23 NL NL7409919.A patent/NL159381B/xx not_active IP Right Cessation
- 1974-07-23 GB GB4007476A patent/GB1476215A/en not_active Expired
- 1974-07-23 GB GB3258074A patent/GB1476214A/en not_active Expired
- 1974-07-23 CA CA000205427A patent/CA1153383A/en not_active Expired
- 1974-07-23 DK DK396874A patent/DK396874A/da not_active Application Discontinuation
- 1974-07-23 SE SE7409577A patent/SE7409577L/xx not_active Application Discontinuation
- 1974-07-24 DE DE2435613A patent/DE2435613B2/de not_active Withdrawn
- 1974-07-24 CH CH478877A patent/CH605896A5/xx not_active IP Right Cessation
- 1974-07-24 CH CH479077A patent/CH605898A5/xx not_active IP Right Cessation
- 1974-07-24 BE BE146913A patent/BE818055A/xx not_active IP Right Cessation
- 1974-07-24 CH CH1504677A patent/CH605900A5/xx not_active IP Right Cessation
- 1974-07-24 CH CH479177A patent/CH605899A5/xx not_active IP Right Cessation
- 1974-07-24 AR AR254870A patent/AR210725A1/es active
- 1974-07-24 CH CH478977A patent/CH605897A5/xx not_active IP Right Cessation
- 1974-07-24 CH CH1019574A patent/CH594658A5/xx not_active IP Right Cessation
-
1977
- 1977-05-13 SE SE7705637A patent/SE7705637L/xx not_active Application Discontinuation
-
1981
- 1981-12-25 YU YU03094/81A patent/YU309481A/xx unknown
- 1981-12-25 YU YU03092/81A patent/YU309281A/xx unknown
- 1981-12-25 YU YU03090/81A patent/YU309081A/xx unknown
- 1981-12-25 YU YU03093/81A patent/YU309381A/xx unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0003893A1 (en) * | 1978-02-17 | 1979-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel dibenz (b,f) oxepin and dibenzo (b,f) thiepin compounds and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions containing them |
| US4356186A (en) | 1980-03-31 | 1982-10-26 | Dainippon Pharmaceutical Co., Ltd. | Acetic acid derivatives and composition containing the same |
| US4576960A (en) * | 1981-12-23 | 1986-03-18 | Hoechst Roussel Pharmaceuticals Incorporated | 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin derivatives |
| US4526891A (en) * | 1983-03-10 | 1985-07-02 | Hoechst Roussel Pharmaceuticals Inc. | Substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins |
| CN106518833A (zh) * | 2015-09-15 | 2017-03-22 | 江苏吉贝尔药业股份有限公司 | 一种新的6，11-二氢-11-氧代二苯并［b，e］噁庚因-2-乙酸制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CH605897A5 (ro) | 1978-10-13 |
| GB1476215A (en) | 1977-06-10 |
| AR210725A1 (es) | 1977-09-15 |
| CH605899A5 (ro) | 1978-10-13 |
| FR2245356B1 (ro) | 1978-10-13 |
| CH605898A5 (ro) | 1978-10-13 |
| DE2435613A1 (de) | 1975-02-27 |
| YU309481A (en) | 1983-06-30 |
| YU204274A (en) | 1982-06-30 |
| NL7409919A (nl) | 1975-01-28 |
| FR2245356A1 (ro) | 1975-04-25 |
| NL159381B (nl) | 1979-02-15 |
| YU309081A (en) | 1983-06-30 |
| CA1153383A (en) | 1983-09-06 |
| BE818055A (fr) | 1974-11-18 |
| SE7409577L (ro) | 1975-01-27 |
| DE2435613B2 (de) | 1979-07-05 |
| AU7143174A (en) | 1976-01-22 |
| DK396874A (ro) | 1975-03-17 |
| CH605896A5 (ro) | 1978-10-13 |
| YU309281A (en) | 1983-06-30 |
| YU309381A (en) | 1983-06-30 |
| CH605900A5 (ro) | 1978-10-13 |
| CH594658A5 (ro) | 1978-01-13 |
| SE7705637L (sv) | 1977-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |