GB1458676A - Orally administrable corticosteroid preparations - Google Patents
Orally administrable corticosteroid preparationsInfo
- Publication number
- GB1458676A GB1458676A GB5709073A GB5709073A GB1458676A GB 1458676 A GB1458676 A GB 1458676A GB 5709073 A GB5709073 A GB 5709073A GB 5709073 A GB5709073 A GB 5709073A GB 1458676 A GB1458676 A GB 1458676A
- Authority
- GB
- United Kingdom
- Prior art keywords
- layer
- corticosteroid
- prednisolone
- soluble
- taken
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003246 corticosteroid Substances 0.000 title abstract 7
- 238000002360 preparation method Methods 0.000 title 1
- 229960005205 prednisolone Drugs 0.000 abstract 3
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 abstract 3
- 238000010521 absorption reaction Methods 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 210000004051 gastric juice Anatomy 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 abstract 1
- 101800000414 Corticotropin Proteins 0.000 abstract 1
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 abstract 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 abstract 1
- ITRJWOMZKQRYTA-RFZYENFJSA-N Cortisone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)CC2=O ITRJWOMZKQRYTA-RFZYENFJSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 abstract 1
- 102100027467 Pro-opiomelanocortin Human genes 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 235000021152 breakfast Nutrition 0.000 abstract 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 abstract 1
- 230000027288 circadian rhythm Effects 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
- 229960000258 corticotropin Drugs 0.000 abstract 1
- 229960004544 cortisone Drugs 0.000 abstract 1
- 229960003290 cortisone acetate Drugs 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 229960004584 methylprednisolone Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960004618 prednisone Drugs 0.000 abstract 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- 230000001360 synchronised effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2260384A DE2260384C3 (de) | 1972-12-09 | 1972-12-09 | Oral zu applizierendes Corticosteroid-Präparat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1458676A true GB1458676A (en) | 1976-12-15 |
Family
ID=5864005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5709073A Expired GB1458676A (en) | 1972-12-09 | 1973-12-10 | Orally administrable corticosteroid preparations |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS4986527A (enExample) |
| KR (1) | KR780000243B1 (enExample) |
| AT (1) | AT345983B (enExample) |
| BE (1) | BE808442A (enExample) |
| CA (1) | CA1027864A (enExample) |
| DE (1) | DE2260384C3 (enExample) |
| FR (1) | FR2209585B1 (enExample) |
| GB (1) | GB1458676A (enExample) |
| HU (1) | HU171907B (enExample) |
| IE (1) | IE38614B1 (enExample) |
| IL (1) | IL43764A (enExample) |
| NL (1) | NL7316585A (enExample) |
| ZA (1) | ZA739327B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005102271A3 (en) * | 2004-04-22 | 2006-08-03 | Duocort Ab | Pharmaceutical compositions for glucocorticoid replacement therapy |
| WO2010115615A1 (en) * | 2009-04-07 | 2010-10-14 | Duocort Pharma Ab | Improved glucocorticoid therapy |
| US9925139B2 (en) | 2004-04-22 | 2018-03-27 | Acucort Ab | Pharmaceutical compositions for acute glucocorticoid therapy |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1392321B1 (en) * | 2001-03-15 | 2010-08-18 | Soligenix, Inc. | Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids |
| EP3403654B1 (en) * | 2009-10-01 | 2019-07-31 | Adare Development I, L.P. | Orally administered corticosteroid compositions |
| WO2015034678A2 (en) | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
| TWI777515B (zh) | 2016-08-18 | 2022-09-11 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB862376A (en) * | 1957-10-10 | 1961-03-08 | Pfizer & Co C | Sustained release pharmaceutical tablet |
-
1972
- 1972-12-09 DE DE2260384A patent/DE2260384C3/de not_active Expired
-
1973
- 1973-12-03 KR KR7302039A patent/KR780000243B1/ko not_active Expired
- 1973-12-03 FR FR7343036A patent/FR2209585B1/fr not_active Expired
- 1973-12-04 NL NL7316585A patent/NL7316585A/xx not_active Application Discontinuation
- 1973-12-06 IL IL43764A patent/IL43764A/en unknown
- 1973-12-06 CA CA187,580A patent/CA1027864A/en not_active Expired
- 1973-12-06 HU HU73HO00001633A patent/HU171907B/hu unknown
- 1973-12-07 AT AT1026773A patent/AT345983B/de active
- 1973-12-07 ZA ZA739327A patent/ZA739327B/xx unknown
- 1973-12-07 IE IE2216/73A patent/IE38614B1/xx unknown
- 1973-12-08 JP JP48137285A patent/JPS4986527A/ja active Pending
- 1973-12-10 BE BE138701A patent/BE808442A/xx unknown
- 1973-12-10 GB GB5709073A patent/GB1458676A/en not_active Expired
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005102271A3 (en) * | 2004-04-22 | 2006-08-03 | Duocort Ab | Pharmaceutical compositions for glucocorticoid replacement therapy |
| AU2005235370B2 (en) * | 2004-04-22 | 2011-06-09 | Takeda Pharmaceutical Company Limited | Pharmaceutical compositions for glucocorticoid replacement therapy |
| US8425937B2 (en) | 2004-04-22 | 2013-04-23 | Duocort Pharma Ab | Pharmaceutical compositions for glucocorticoid replacement therapy |
| CN1942176B (zh) * | 2004-04-22 | 2013-09-18 | 杜奥科特药物公司 | 用于糖皮质激素替代疗法的药物组合物 |
| CN103006592B (zh) * | 2004-04-22 | 2016-03-02 | 杜奥科特药物公司 | 用于糖皮质激素替代疗法的药物组合物 |
| EP3072507A1 (en) * | 2004-04-22 | 2016-09-28 | DuoCort Pharma AB | Pharmaceutical compositions for glucocorticoid replacement therapy |
| US9925139B2 (en) | 2004-04-22 | 2018-03-27 | Acucort Ab | Pharmaceutical compositions for acute glucocorticoid therapy |
| US10583146B2 (en) | 2004-04-22 | 2020-03-10 | Shire Viropharma Incorporated | Pharmaceutical compositions for glucocorticoid replacement therapy |
| WO2010115615A1 (en) * | 2009-04-07 | 2010-10-14 | Duocort Pharma Ab | Improved glucocorticoid therapy |
| CN102448464A (zh) * | 2009-04-07 | 2012-05-09 | 杜奥科特药物公司 | 改进的糖皮质激素疗法 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2209585B1 (enExample) | 1977-09-02 |
| AU6328073A (en) | 1975-06-12 |
| IL43764A0 (en) | 1974-03-14 |
| ZA739327B (en) | 1974-10-30 |
| CA1027864A (en) | 1978-03-14 |
| HU171907B (hu) | 1978-04-28 |
| JPS4986527A (enExample) | 1974-08-19 |
| ATA1026773A (de) | 1978-02-15 |
| DE2260384C3 (de) | 1979-11-29 |
| FR2209585A1 (enExample) | 1974-07-05 |
| DE2260384A1 (de) | 1974-06-12 |
| IE38614L (en) | 1974-06-09 |
| IE38614B1 (en) | 1978-04-26 |
| DE2260384B2 (de) | 1979-04-12 |
| BE808442A (fr) | 1974-06-10 |
| AT345983B (de) | 1978-10-10 |
| NL7316585A (enExample) | 1974-06-11 |
| IL43764A (en) | 1977-03-31 |
| KR780000243B1 (en) | 1978-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |