GB1457632A - Adriamycins - Google Patents

Adriamycins

Info

Publication number
GB1457632A
GB1457632A GB1278374A GB1278374A GB1457632A GB 1457632 A GB1457632 A GB 1457632A GB 1278374 A GB1278374 A GB 1278374A GB 1278374 A GB1278374 A GB 1278374A GB 1457632 A GB1457632 A GB 1457632A
Authority
GB
United Kingdom
Prior art keywords
beta
anomer
protecting
epiadriamycin
adriamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1278374A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Priority to GB1278374A priority Critical patent/GB1457632A/en
Priority to NLAANVRAGE7502934,A priority patent/NL176635C/xx
Priority to DE2510866A priority patent/DE2510866C3/de
Priority to AT207475A priority patent/AT338420B/de
Priority to US05/560,104 priority patent/US4058519A/en
Priority to AU79263/75A priority patent/AU497500B2/en
Priority to FR7508548A priority patent/FR2264555B1/fr
Priority to JP50033095A priority patent/JPS5840555B2/ja
Priority to ZA00751781A priority patent/ZA751781B/xx
Priority to DK114475A priority patent/DK153158C/da
Priority to SE7503215A priority patent/SE434844B/xx
Priority to CA222,609A priority patent/CA1046507A/en
Priority to CH365975A priority patent/CH612947A5/xx
Priority to BE154581A priority patent/BE826978A/xx
Priority to SU7502115054A priority patent/SU583763A3/ru
Priority to ES435833A priority patent/ES435833A1/es
Publication of GB1457632A publication Critical patent/GB1457632A/en
Priority to US05/823,581 priority patent/US4098798A/en
Priority to HK8/82A priority patent/HK882A/xx
Priority to MYPI88001026A priority patent/MY103912A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
GB1278374A 1974-03-22 1974-03-22 Adriamycins Expired GB1457632A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
GB1278374A GB1457632A (en) 1974-03-22 1974-03-22 Adriamycins
NLAANVRAGE7502934,A NL176635C (nl) 1974-03-22 1975-03-12 Werkwijze voor het bereiden van anti-tumor-middelen en daarvoor geschikte geneeskrachtige verbindingen.
DE2510866A DE2510866C3 (de) 1974-03-22 1975-03-13 4'-epi-Adriamycin a - und ß -Anomer, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
AT207475A AT338420B (de) 1974-03-22 1975-03-18 Verfahren zur herstellung von adriamycinen
US05/560,104 US4058519A (en) 1974-03-22 1975-03-19 Adriamycins and uses thereof
AU79263/75A AU497500B2 (en) 1974-03-22 1975-03-19 Adriamycins
FR7508548A FR2264555B1 (cg-RX-API-DMAC7.html) 1974-03-22 1975-03-19
DK114475A DK153158C (da) 1974-03-22 1975-03-20 Fremgangsmaade for fremstilling af en adriamycinon glycosid
ZA00751781A ZA751781B (en) 1974-03-22 1975-03-20 Adriamycins
JP50033095A JPS5840555B2 (ja) 1974-03-22 1975-03-20 アドリアマイシンルイノ セイホウ
SE7503215A SE434844B (sv) 1974-03-22 1975-03-20 Analogiforfarande for framstellning av 4?721 epi-adriamycin i form av dess alfa- resp beta anomer
CA222,609A CA1046507A (en) 1974-03-22 1975-03-20 Process for the preparation of adriamycins
SU7502115054A SU583763A3 (ru) 1974-03-22 1975-03-21 Способ получени адриамицинов
BE154581A BE826978A (fr) 1974-03-22 1975-03-21 Procede de preparation des adriamycines et nouveaux produits obtenus
CH365975A CH612947A5 (cg-RX-API-DMAC7.html) 1974-03-22 1975-03-21
ES435833A ES435833A1 (es) 1974-03-22 1975-03-21 Un procedimiento para la sintesis de glicosidos de adriami-cinona.
US05/823,581 US4098798A (en) 1974-03-22 1977-08-11 Adriamycins, process for their preparation and uses thereof
HK8/82A HK882A (en) 1974-03-22 1982-01-14 Adriamycins
MYPI88001026A MY103912A (en) 1974-03-22 1988-09-14 Adriamycin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1278374A GB1457632A (en) 1974-03-22 1974-03-22 Adriamycins

Publications (1)

Publication Number Publication Date
GB1457632A true GB1457632A (en) 1976-12-08

Family

ID=10011048

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1278374A Expired GB1457632A (en) 1974-03-22 1974-03-22 Adriamycins

Country Status (18)

Country Link
US (1) US4058519A (cg-RX-API-DMAC7.html)
JP (1) JPS5840555B2 (cg-RX-API-DMAC7.html)
AT (1) AT338420B (cg-RX-API-DMAC7.html)
AU (1) AU497500B2 (cg-RX-API-DMAC7.html)
BE (1) BE826978A (cg-RX-API-DMAC7.html)
CA (1) CA1046507A (cg-RX-API-DMAC7.html)
CH (1) CH612947A5 (cg-RX-API-DMAC7.html)
DE (1) DE2510866C3 (cg-RX-API-DMAC7.html)
DK (1) DK153158C (cg-RX-API-DMAC7.html)
ES (1) ES435833A1 (cg-RX-API-DMAC7.html)
FR (1) FR2264555B1 (cg-RX-API-DMAC7.html)
GB (1) GB1457632A (cg-RX-API-DMAC7.html)
HK (1) HK882A (cg-RX-API-DMAC7.html)
MY (1) MY103912A (cg-RX-API-DMAC7.html)
NL (1) NL176635C (cg-RX-API-DMAC7.html)
SE (1) SE434844B (cg-RX-API-DMAC7.html)
SU (1) SU583763A3 (cg-RX-API-DMAC7.html)
ZA (1) ZA751781B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023453A1 (fr) * 1998-10-16 2000-04-27 Mercian Corporation Cristallisation de chlorhydrate de doxorubicine

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133877A (en) * 1976-07-08 1979-01-09 Societa Farmaceutici Italia S.P.A. Anthracycline ethers and use therefor
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
US4345068A (en) * 1979-11-22 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-epidaunorubicin, 3',4'-diepidaunorubicin, their doxorubicin analogs, and intermediates used in said process
US4393052A (en) * 1980-11-01 1983-07-12 Farmitalia Carlo Erba S.P.A. Antitumor anthracycline glycosides, their preparation, intermediates therefor, and compositions and use thereof
DE51280T1 (de) * 1980-11-01 1983-01-20 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclin-glycoside, verfahren zu ihrer herstellung, zwischenprodukte und ihre herstellung und arzneimittel.
US4562177A (en) * 1982-08-17 1985-12-31 The Ohio State University Research Foundation 3'-Amino-2' halo-anthracycline antibiotics
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same
DE3500029A1 (de) * 1985-01-02 1986-09-04 Farmitalia Carlo Erba S.p.A., Mailand/Milano Anthracyclinester
GB2169284A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Epidoxorubicin-14-esters
JPS61172891A (ja) * 1985-01-24 1986-08-04 フア−ミタリア・カルロ・エルバ・ソシエタ・ペル・アツイオ−ニ アントラサイクリン類エステルの製法
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
PT848009E (pt) 1996-12-16 2000-11-30 Pharmachemie Bv Processo para a preparacao de epirubicina ou seus sais de adicao de acido a partir de daunorubicina
KR100850408B1 (ko) * 2000-08-10 2008-08-04 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
KR100785966B1 (ko) * 2000-08-10 2007-12-14 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
WO2005004805A2 (en) * 2003-07-02 2005-01-20 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
EP1845974A1 (en) 2005-01-21 2007-10-24 Astex Therapeutics Limited Pharmaceutical compounds
PL375008A1 (pl) 2005-05-12 2006-11-13 Institut National De La Sante Et De La Recherche Medicale, Inserm Nowe zastosowanie medyczne chlorowodorku epirubicyny
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CL2009002206A1 (es) 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
AR074897A1 (es) 2008-12-23 2011-02-23 Pharmasset Inc Fosforamidatos de nucleosidos
MX2011006890A (es) 2008-12-23 2011-07-20 Pharmasset Inc Analogos de nucleosidos.
AP2012006535A0 (en) 2010-03-31 2012-10-31 Gilead Pharmasset Llc Stereoselective synthesis of phosphorous containing actives
CN108473523B (zh) * 2016-01-11 2022-03-15 浙江海正药业股份有限公司 一种盐酸表柔比星的制备方法及其中间体
CN120661674A (zh) 2016-03-15 2025-09-19 奥莱松基因组股份有限公司 用于治疗实体瘤的lsd1抑制剂的组合

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3356674A (en) * 1961-07-07 1967-12-05 Rikagaku Kenkyusho 3-c-hydroxymethyl-3, 5-didesoxy-l-lyxofuranose and its derivatives, and a process for the production thereof
US3427300A (en) * 1965-11-12 1969-02-11 Merck & Co Inc Anti-inflammatory steroid 2'-acetamido-2'-deoxy-glucoside compounds
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
US3629231A (en) * 1968-05-23 1971-12-21 Biorex Laboratories Ltd Derivatives of glycyrrhetinic acid
US3651090A (en) * 1969-12-17 1972-03-21 Cutter Lab 1 3-dioxolan-4-yl-alkyl guanidines
FR2183710A1 (en) * 1972-05-06 1973-12-21 Farmaceutici Italia Daunomycin (hydrochloride) prepn - by reaction of daunomycinone with daunosamines, useful as antitumour agent and anti-leucemic

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023453A1 (fr) * 1998-10-16 2000-04-27 Mercian Corporation Cristallisation de chlorhydrate de doxorubicine
US6653455B1 (en) 1998-10-16 2003-11-25 Mercian Corporation Crystallization of doxorubicin hydrochloride

Also Published As

Publication number Publication date
CA1046507A (en) 1979-01-16
HK882A (en) 1982-01-22
DK153158C (da) 1989-01-16
NL176635C (nl) 1985-05-17
DK153158B (da) 1988-06-20
DE2510866B2 (de) 1979-12-06
MY103912A (en) 1993-10-30
NL176635B (nl) 1984-12-17
ES435833A1 (es) 1976-12-01
AU497500B2 (en) 1978-12-14
DE2510866C3 (de) 1980-08-14
SU583763A3 (ru) 1977-12-05
AT338420B (de) 1977-08-25
US4058519A (en) 1977-11-15
JPS50126656A (cg-RX-API-DMAC7.html) 1975-10-04
CH612947A5 (cg-RX-API-DMAC7.html) 1979-08-31
ATA207475A (de) 1976-12-15
JPS5840555B2 (ja) 1983-09-06
FR2264555B1 (cg-RX-API-DMAC7.html) 1980-01-11
NL7502934A (nl) 1975-09-24
SE7503215L (cg-RX-API-DMAC7.html) 1975-09-23
DE2510866A1 (de) 1975-10-02
ZA751781B (en) 1976-02-25
AU7926375A (en) 1976-09-23
SE434844B (sv) 1984-08-20
FR2264555A1 (cg-RX-API-DMAC7.html) 1975-10-17
DK114475A (cg-RX-API-DMAC7.html) 1975-09-23
BE826978A (fr) 1975-09-22

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Legal Events

Date Code Title Description
416 Proceeding under section 16 patents act 1949
PS Patent sealed [section 19, patents act 1949]
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19950317