GB1457559A - Daunomycins - Google Patents
DaunomycinsInfo
- Publication number
- GB1457559A GB1457559A GB1225474A GB1225474A GB1457559A GB 1457559 A GB1457559 A GB 1457559A GB 1225474 A GB1225474 A GB 1225474A GB 1225474 A GB1225474 A GB 1225474A GB 1457559 A GB1457559 A GB 1457559A
- Authority
- GB
- United Kingdom
- Prior art keywords
- anomers
- daunomycin
- compounds
- trifluoroacetoxyhexose
- lyxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YOFDHOWPGULAQF-MQJDWESPSA-N (7s,9s)-9-acetyl-6,7,9,11-tetrahydroxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound C1[C@@](O)(C(C)=O)C[C@H](O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-MQJDWESPSA-N 0.000 abstract 1
- STQGQHZAVUOBTE-HQXHJQOISA-N (7s,9s)-9-acetyl-7-[(2r,4r,5s,6r)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@@H](N)[C@H](O)[C@@H](C)O1 STQGQHZAVUOBTE-HQXHJQOISA-N 0.000 abstract 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
- WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 abstract 1
- YOFDHOWPGULAQF-UHFFFAOYSA-N Daunomycin-Aglycone Natural products C1C(O)(C(C)=O)CC(O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000004748 cultured cell Anatomy 0.000 abstract 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
- 229930182470 glycoside Natural products 0.000 abstract 1
- -1 glycoside compounds Chemical class 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000002730 mercury Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000011278 mitosis Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1225474A GB1457559A (en) | 1974-03-20 | 1974-03-20 | Daunomycins |
| DE2510926A DE2510926C3 (de) | 1974-03-20 | 1975-03-13 | 4'-epi-Daunomycuie, deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| NLAANVRAGE7503079,A NL176636C (nl) | 1974-03-20 | 1975-03-14 | Werkwijze voor het bereiden van anti-tumormiddelen en daarvoor geschikte geneeskrachtige verbindingen. |
| AT202875A AT338419B (de) | 1974-03-20 | 1975-03-17 | Verfahren zur herstellung von daunomycinen |
| ZA00751687A ZA751687B (en) | 1974-03-20 | 1975-03-18 | Daunomycins |
| SU752129602A SU589926A3 (ru) | 1974-03-20 | 1975-03-18 | Способ получени дауномицинов |
| SE7503084A SE434843B (sv) | 1974-03-20 | 1975-03-18 | Analogiforfarande for framstellning av 4?721-epi-daunomycin i form av dess alfa- resp beta-anomer |
| AU79197/75A AU490236B2 (en) | 1974-03-20 | 1975-03-18 | Daunomycins |
| DK109275A DK146541C (da) | 1974-03-20 | 1975-03-18 | Analogifremgangsmaade til fremstilling af 4'-epi-daunomycin eller de individuelle alfa- eller beta-anomere deraf |
| JP50033493A JPS5833880B2 (ja) | 1974-03-20 | 1975-03-19 | ダウノマイシンルイノセイホウ |
| CH352975A CH615198A5 (en) | 1974-03-20 | 1975-03-19 | Process for the preparation of daunomycin |
| FR7508547A FR2264554B1 (enrdf_load_html_response) | 1974-03-20 | 1975-03-19 | |
| BE154470A BE826848A (fr) | 1974-03-20 | 1975-03-19 | Les daunomycines et leur procede de preparation |
| CA222,610A CA1046508A (en) | 1974-03-20 | 1975-03-20 | Process for the preparation of daunomycins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1225474A GB1457559A (en) | 1974-03-20 | 1974-03-20 | Daunomycins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1457559A true GB1457559A (en) | 1976-12-08 |
Family
ID=10001195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1225474A Expired GB1457559A (en) | 1974-03-20 | 1974-03-20 | Daunomycins |
Country Status (13)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5124317A (en) | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.P.A. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| US5977082A (en) * | 1985-08-02 | 1999-11-02 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| FR2678274A1 (fr) * | 1991-06-25 | 1992-12-31 | Medgenix Group Sa | N-leucyl epirubicine application a titre de medicament antitumoral et procede de preparation. |
-
1974
- 1974-03-20 GB GB1225474A patent/GB1457559A/en not_active Expired
-
1975
- 1975-03-13 DE DE2510926A patent/DE2510926C3/de not_active Expired
- 1975-03-14 NL NLAANVRAGE7503079,A patent/NL176636C/xx not_active IP Right Cessation
- 1975-03-17 AT AT202875A patent/AT338419B/de not_active IP Right Cessation
- 1975-03-18 SU SU752129602A patent/SU589926A3/ru active
- 1975-03-18 SE SE7503084A patent/SE434843B/xx not_active IP Right Cessation
- 1975-03-18 ZA ZA00751687A patent/ZA751687B/xx unknown
- 1975-03-18 DK DK109275A patent/DK146541C/da not_active IP Right Cessation
- 1975-03-19 BE BE154470A patent/BE826848A/xx not_active IP Right Cessation
- 1975-03-19 JP JP50033493A patent/JPS5833880B2/ja not_active Expired
- 1975-03-19 FR FR7508547A patent/FR2264554B1/fr not_active Expired
- 1975-03-19 CH CH352975A patent/CH615198A5/de not_active IP Right Cessation
- 1975-03-20 CA CA222,610A patent/CA1046508A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA751687B (en) | 1976-02-25 |
| JPS5833880B2 (ja) | 1983-07-22 |
| DK146541B (da) | 1983-10-31 |
| DE2510926C3 (de) | 1980-03-13 |
| CA1046508A (en) | 1979-01-16 |
| ATA202875A (de) | 1976-12-15 |
| NL7503079A (nl) | 1975-09-23 |
| DE2510926A1 (de) | 1975-09-25 |
| FR2264554B1 (enrdf_load_html_response) | 1978-07-28 |
| FR2264554A1 (enrdf_load_html_response) | 1975-10-17 |
| SU589926A3 (ru) | 1978-01-25 |
| NL176636C (nl) | 1985-05-17 |
| BE826848A (fr) | 1975-09-19 |
| DK109275A (enrdf_load_html_response) | 1975-09-21 |
| CH615198A5 (en) | 1980-01-15 |
| SE7503084L (enrdf_load_html_response) | 1975-09-22 |
| NL176636B (nl) | 1984-12-17 |
| AT338419B (de) | 1977-08-25 |
| AU7919775A (en) | 1976-09-23 |
| JPS50126657A (enrdf_load_html_response) | 1975-10-04 |
| SE434843B (sv) | 1984-08-20 |
| DK146541C (da) | 1984-04-09 |
| DE2510926B2 (de) | 1979-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 416 | Proceeding under section 16 patents act 1949 | ||
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19950316 |