GB1457559A - Daunomycins - Google Patents

Daunomycins

Info

Publication number
GB1457559A
GB1457559A GB1225474A GB1225474A GB1457559A GB 1457559 A GB1457559 A GB 1457559A GB 1225474 A GB1225474 A GB 1225474A GB 1225474 A GB1225474 A GB 1225474A GB 1457559 A GB1457559 A GB 1457559A
Authority
GB
United Kingdom
Prior art keywords
anomers
daunomycin
compounds
trifluoroacetoxyhexose
lyxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1225474A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Priority to GB1225474A priority Critical patent/GB1457559A/en
Priority to DE2510926A priority patent/DE2510926C3/en
Priority to NLAANVRAGE7503079,A priority patent/NL176636C/en
Priority to AT202875A priority patent/AT338419B/en
Priority to DK109275A priority patent/DK146541C/en
Priority to SE7503084A priority patent/SE434843B/en
Priority to SU752129602A priority patent/SU589926A3/en
Priority to AU79197/75A priority patent/AU490236B2/en
Priority to ZA00751687A priority patent/ZA751687B/en
Priority to BE154470A priority patent/BE826848A/en
Priority to CH352975A priority patent/CH615198A5/en
Priority to JP50033493A priority patent/JPS5833880B2/en
Priority to FR7508547A priority patent/FR2264554B1/fr
Priority to CA222,610A priority patent/CA1046508A/en
Publication of GB1457559A publication Critical patent/GB1457559A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

The process for the preparation of daunomycin and of 4'-epi-daunomycin and the corresponding ss anomers comprises reacting daunomycinone with a 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxyhexose which has the L-lyxo or L-arabino configuration in an organic solvent in the presence of a mercury salt as catalyst and of a hydrogen chloride acceptor and then removing the trifluoroacetyl protective groups in the glycoside compounds which are formed, and separating the alpha and ss anomers. The compounds display excellent biological properties as potent inhibitors of cell mitosis and proliferative activity in cultured cells in vitro.
GB1225474A 1974-03-20 1974-03-20 Daunomycins Expired GB1457559A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
GB1225474A GB1457559A (en) 1974-03-20 1974-03-20 Daunomycins
DE2510926A DE2510926C3 (en) 1974-03-20 1975-03-13 4'-epi-Daunomycuie, their preparation and pharmaceutical compositions containing these compounds
NLAANVRAGE7503079,A NL176636C (en) 1974-03-20 1975-03-14 METHOD FOR PREPARING ANTI-TUMOR AGENTS AND MEDICINE COMPOUNDS SUITABLE FOR THESE
AT202875A AT338419B (en) 1974-03-20 1975-03-17 METHOD OF MANUFACTURING DAUNOMYCINES
DK109275A DK146541C (en) 1974-03-20 1975-03-18 METHOD OF ANALOGUE FOR THE PREPARATION OF 4'-EPI-DAUNOMYCINE OR ITS INDIVIDUAL ALFA OR BETA ANOMERS THEREOF
SE7503084A SE434843B (en) 1974-03-20 1975-03-18 ANALOGICAL PROCEDURE FOR THE PREPARATION OF 4,721-EPI-DAUNOMYCIN IN THE FORM OF ITS ALPHA RESP BETA ANOMERS
SU752129602A SU589926A3 (en) 1974-03-20 1975-03-18 Method of preparing daunomycines
AU79197/75A AU490236B2 (en) 1974-03-20 1975-03-18 Daunomycins
ZA00751687A ZA751687B (en) 1974-03-20 1975-03-18 Daunomycins
BE154470A BE826848A (en) 1974-03-20 1975-03-19 DAUNOMYCINS AND THEIR PREPARATION PROCESS
CH352975A CH615198A5 (en) 1974-03-20 1975-03-19 Process for the preparation of daunomycin
JP50033493A JPS5833880B2 (en) 1974-03-20 1975-03-19 Daunomycin
FR7508547A FR2264554B1 (en) 1974-03-20 1975-03-19
CA222,610A CA1046508A (en) 1974-03-20 1975-03-20 Process for the preparation of daunomycins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1225474A GB1457559A (en) 1974-03-20 1974-03-20 Daunomycins

Publications (1)

Publication Number Publication Date
GB1457559A true GB1457559A (en) 1976-12-08

Family

ID=10001195

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1225474A Expired GB1457559A (en) 1974-03-20 1974-03-20 Daunomycins

Country Status (13)

Country Link
JP (1) JPS5833880B2 (en)
AT (1) AT338419B (en)
BE (1) BE826848A (en)
CA (1) CA1046508A (en)
CH (1) CH615198A5 (en)
DE (1) DE2510926C3 (en)
DK (1) DK146541C (en)
FR (1) FR2264554B1 (en)
GB (1) GB1457559A (en)
NL (1) NL176636C (en)
SE (1) SE434843B (en)
SU (1) SU589926A3 (en)
ZA (1) ZA751687B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
FR2678274A1 (en) * 1991-06-25 1992-12-31 Medgenix Group Sa N-Leucylepirubicin, application as antitumour medicinal product and process for preparing it

Also Published As

Publication number Publication date
JPS50126657A (en) 1975-10-04
CH615198A5 (en) 1980-01-15
DE2510926A1 (en) 1975-09-25
NL176636C (en) 1985-05-17
DK146541B (en) 1983-10-31
SE7503084L (en) 1975-09-21
ATA202875A (en) 1976-12-15
AT338419B (en) 1977-08-25
NL176636B (en) 1984-12-17
CA1046508A (en) 1979-01-16
ZA751687B (en) 1976-02-25
FR2264554A1 (en) 1975-10-17
NL7503079A (en) 1975-09-23
SE7503084A (en) 1975-09-22
DE2510926C3 (en) 1980-03-13
BE826848A (en) 1975-09-19
FR2264554B1 (en) 1978-07-28
AU7919775A (en) 1976-09-23
DE2510926B2 (en) 1979-07-19
SE434843B (en) 1984-08-20
SU589926A3 (en) 1978-01-25
JPS5833880B2 (en) 1983-07-22
DK146541C (en) 1984-04-09
DK109275A (en) 1975-09-21

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Legal Events

Date Code Title Description
416 Proceeding under section 16 patents act 1949
PS Patent sealed
PE20 Patent expired after termination of 20 years

Effective date: 19950316