SE7503084A - - Google Patents

Info

Publication number
SE7503084A
SE7503084A SE7503084A SE7503084A SE7503084A SE 7503084 A SE7503084 A SE 7503084A SE 7503084 A SE7503084 A SE 7503084A SE 7503084 A SE7503084 A SE 7503084A SE 7503084 A SE7503084 A SE 7503084A
Authority
SE
Sweden
Prior art keywords
anomers
daunomycin
compounds
trifluoroacetoxyhexose
lyxo
Prior art date
Application number
SE7503084A
Other versions
SE7503084L (en
SE434843B (en
Inventor
F Arcamone
Marco A Di
S Penco
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Publication of SE7503084L publication Critical patent/SE7503084L/xx
Publication of SE7503084A publication Critical patent/SE7503084A/xx
Publication of SE434843B publication Critical patent/SE434843B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/252Naphthacene radicals, e.g. daunomycins, adriamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The process for the preparation of daunomycin and of 4'-epi-daunomycin and the corresponding ss anomers comprises reacting daunomycinone with a 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxyhexose which has the L-lyxo or L-arabino configuration in an organic solvent in the presence of a mercury salt as catalyst and of a hydrogen chloride acceptor and then removing the trifluoroacetyl protective groups in the glycoside compounds which are formed, and separating the alpha and ss anomers. The compounds display excellent biological properties as potent inhibitors of cell mitosis and proliferative activity in cultured cells in vitro.
SE7503084A 1974-03-20 1975-03-18 ANALOGICAL PROCEDURE FOR THE PREPARATION OF 4,721-EPI-DAUNOMYCIN IN THE FORM OF ITS ALPHA RESP BETA ANOMERS SE434843B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1225474A GB1457559A (en) 1974-03-20 1974-03-20 Daunomycins

Publications (3)

Publication Number Publication Date
SE7503084L SE7503084L (en) 1975-09-21
SE7503084A true SE7503084A (en) 1975-09-22
SE434843B SE434843B (en) 1984-08-20

Family

ID=10001195

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7503084A SE434843B (en) 1974-03-20 1975-03-18 ANALOGICAL PROCEDURE FOR THE PREPARATION OF 4,721-EPI-DAUNOMYCIN IN THE FORM OF ITS ALPHA RESP BETA ANOMERS

Country Status (13)

Country Link
JP (1) JPS5833880B2 (en)
AT (1) AT338419B (en)
BE (1) BE826848A (en)
CA (1) CA1046508A (en)
CH (1) CH615198A5 (en)
DE (1) DE2510926C3 (en)
DK (1) DK146541C (en)
FR (1) FR2264554B1 (en)
GB (1) GB1457559A (en)
NL (1) NL176636C (en)
SE (1) SE434843B (en)
SU (1) SU589926A3 (en)
ZA (1) ZA751687B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124317A (en) 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
FR2678274A1 (en) * 1991-06-25 1992-12-31 Medgenix Group Sa N-Leucylepirubicin, application as antitumour medicinal product and process for preparing it

Also Published As

Publication number Publication date
NL7503079A (en) 1975-09-23
GB1457559A (en) 1976-12-08
DE2510926C3 (en) 1980-03-13
JPS50126657A (en) 1975-10-04
SE7503084L (en) 1975-09-21
DK146541C (en) 1984-04-09
AU7919775A (en) 1976-09-23
DE2510926B2 (en) 1979-07-19
DK146541B (en) 1983-10-31
ZA751687B (en) 1976-02-25
ATA202875A (en) 1976-12-15
CA1046508A (en) 1979-01-16
AT338419B (en) 1977-08-25
NL176636B (en) 1984-12-17
CH615198A5 (en) 1980-01-15
SE434843B (en) 1984-08-20
DE2510926A1 (en) 1975-09-25
JPS5833880B2 (en) 1983-07-22
DK109275A (en) 1975-09-21
FR2264554A1 (en) 1975-10-17
SU589926A3 (en) 1978-01-25
NL176636C (en) 1985-05-17
FR2264554B1 (en) 1978-07-28
BE826848A (en) 1975-09-19

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