SE7503084A - - Google Patents
Info
- Publication number
- SE7503084A SE7503084A SE7503084A SE7503084A SE7503084A SE 7503084 A SE7503084 A SE 7503084A SE 7503084 A SE7503084 A SE 7503084A SE 7503084 A SE7503084 A SE 7503084A SE 7503084 A SE7503084 A SE 7503084A
- Authority
- SE
- Sweden
- Prior art keywords
- anomers
- daunomycin
- compounds
- trifluoroacetoxyhexose
- lyxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The process for the preparation of daunomycin and of 4'-epi-daunomycin and the corresponding ss anomers comprises reacting daunomycinone with a 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxyhexose which has the L-lyxo or L-arabino configuration in an organic solvent in the presence of a mercury salt as catalyst and of a hydrogen chloride acceptor and then removing the trifluoroacetyl protective groups in the glycoside compounds which are formed, and separating the alpha and ss anomers. The compounds display excellent biological properties as potent inhibitors of cell mitosis and proliferative activity in cultured cells in vitro.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1225474A GB1457559A (en) | 1974-03-20 | 1974-03-20 | Daunomycins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE7503084L SE7503084L (en) | 1975-09-21 |
| SE7503084A true SE7503084A (en) | 1975-09-22 |
| SE434843B SE434843B (en) | 1984-08-20 |
Family
ID=10001195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7503084A SE434843B (en) | 1974-03-20 | 1975-03-18 | ANALOGICAL PROCEDURE FOR THE PREPARATION OF 4,721-EPI-DAUNOMYCIN IN THE FORM OF ITS ALPHA RESP BETA ANOMERS |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5833880B2 (en) |
| AT (1) | AT338419B (en) |
| BE (1) | BE826848A (en) |
| CA (1) | CA1046508A (en) |
| CH (1) | CH615198A5 (en) |
| DE (1) | DE2510926C3 (en) |
| DK (1) | DK146541C (en) |
| FR (1) | FR2264554B1 (en) |
| GB (1) | GB1457559A (en) |
| NL (1) | NL176636C (en) |
| SE (1) | SE434843B (en) |
| SU (1) | SU589926A3 (en) |
| ZA (1) | ZA751687B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5124317A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.P.A. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| US5977082A (en) * | 1985-08-02 | 1999-11-02 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| FR2678274A1 (en) * | 1991-06-25 | 1992-12-31 | Medgenix Group Sa | N-Leucylepirubicin, application as antitumour medicinal product and process for preparing it |
-
1974
- 1974-03-20 GB GB1225474A patent/GB1457559A/en not_active Expired
-
1975
- 1975-03-13 DE DE2510926A patent/DE2510926C3/en not_active Expired
- 1975-03-14 NL NLAANVRAGE7503079,A patent/NL176636C/en not_active IP Right Cessation
- 1975-03-17 AT AT202875A patent/AT338419B/en not_active IP Right Cessation
- 1975-03-18 ZA ZA00751687A patent/ZA751687B/en unknown
- 1975-03-18 SE SE7503084A patent/SE434843B/en not_active IP Right Cessation
- 1975-03-18 SU SU752129602A patent/SU589926A3/en active
- 1975-03-18 DK DK109275A patent/DK146541C/en not_active IP Right Cessation
- 1975-03-19 FR FR7508547A patent/FR2264554B1/fr not_active Expired
- 1975-03-19 JP JP50033493A patent/JPS5833880B2/en not_active Expired
- 1975-03-19 CH CH352975A patent/CH615198A5/en not_active IP Right Cessation
- 1975-03-19 BE BE154470A patent/BE826848A/en not_active IP Right Cessation
- 1975-03-20 CA CA222,610A patent/CA1046508A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1457559A (en) | 1976-12-08 |
| FR2264554B1 (en) | 1978-07-28 |
| NL7503079A (en) | 1975-09-23 |
| SU589926A3 (en) | 1978-01-25 |
| SE7503084L (en) | 1975-09-21 |
| CH615198A5 (en) | 1980-01-15 |
| DE2510926C3 (en) | 1980-03-13 |
| BE826848A (en) | 1975-09-19 |
| AT338419B (en) | 1977-08-25 |
| JPS5833880B2 (en) | 1983-07-22 |
| ZA751687B (en) | 1976-02-25 |
| FR2264554A1 (en) | 1975-10-17 |
| SE434843B (en) | 1984-08-20 |
| ATA202875A (en) | 1976-12-15 |
| NL176636C (en) | 1985-05-17 |
| DK109275A (en) | 1975-09-21 |
| NL176636B (en) | 1984-12-17 |
| DK146541B (en) | 1983-10-31 |
| AU7919775A (en) | 1976-09-23 |
| CA1046508A (en) | 1979-01-16 |
| DK146541C (en) | 1984-04-09 |
| DE2510926B2 (en) | 1979-07-19 |
| DE2510926A1 (en) | 1975-09-25 |
| JPS50126657A (en) | 1975-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAL | Patent in force |
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