GB1453863A - Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity - Google Patents
Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivityInfo
- Publication number
- GB1453863A GB1453863A GB2400073A GB2400073A GB1453863A GB 1453863 A GB1453863 A GB 1453863A GB 2400073 A GB2400073 A GB 2400073A GB 2400073 A GB2400073 A GB 2400073A GB 1453863 A GB1453863 A GB 1453863A
- Authority
- GB
- United Kingdom
- Prior art keywords
- allergic
- alkyl
- pharmaceutical compositions
- nitrocarbostyrils
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000001900 immune effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 title 1
- 208000026935 allergic disease Diseases 0.000 title 1
- 230000000172 allergic effect Effects 0.000 title 1
- 208000010668 atopic eczema Diseases 0.000 title 1
- 230000009610 hypersensitivity Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229960001317 isoprenaline Drugs 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- -1 phenoxy, benzyloxy Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (29)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2400073A GB1453863A (en) | 1973-05-19 | 1973-05-19 | Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity |
| IE1039/74A IE39269B1 (en) | 1973-05-19 | 1974-05-15 | Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity |
| IL44849A IL44849A (en) | 1973-05-19 | 1974-05-17 | Pharmaceutical compositions containing substituted 4-hydroxy-3-nitrocarbostyrils certain new such compounds and their preparation |
| CA200,335A CA1030539A (en) | 1973-05-19 | 1974-05-17 | 4-hydroxy-3-nitrocarbostyril compounds |
| NL7406711A NL7406711A (enrdf_load_stackoverflow) | 1973-05-19 | 1974-05-17 | |
| AT409674A AT334373B (de) | 1973-05-19 | 1974-05-17 | Verfahren zur herstellung von neuen 4-hydroxy-3-nitrocarbostyrilderivaten und deren salzen |
| SU7402031653A SU578869A3 (ru) | 1973-05-19 | 1974-05-17 | Способ получени 4-окси-3-нитрокарбостирилов |
| BE144489A BE815230A (en) | 1973-05-19 | 1974-05-17 | 3-nitro-carbo styril derivs as anti-allergic agents - esp. for treating asthma, hay fever colds and rhinitis |
| FI1531/74A FI153174A7 (enrdf_load_stackoverflow) | 1973-05-19 | 1974-05-17 | |
| SE7406631A SE7406631L (enrdf_load_stackoverflow) | 1973-05-19 | 1974-05-17 | |
| CH683674A CH601243A5 (enrdf_load_stackoverflow) | 1973-05-19 | 1974-05-17 | |
| ES426427A ES426427A1 (es) | 1973-05-19 | 1974-05-17 | Un procedimiento para la preparacion de nuevos derivados denitrocarboestirilo. |
| DK273074AA DK137043B (da) | 1973-05-19 | 1974-05-17 | Analogifremgangsmåde til fremstilling af nitrocarbostyrilforbindelser. |
| DE2424076A DE2424076A1 (de) | 1973-05-19 | 1974-05-17 | Derivate von 4-hydroxy-3-nitrocarbostyrilen enthaltende arzneimittel, neue 4-hydroxy-3-nitrocarbostyrile und verfahren zu ihrer herstellung |
| HUBE1198A HU168001B (enrdf_load_stackoverflow) | 1973-05-19 | 1974-05-17 | |
| FR7417170A FR2229414B1 (enrdf_load_stackoverflow) | 1973-05-19 | 1974-05-17 | |
| MW21/74*UA MW2174A1 (en) | 1973-05-19 | 1974-05-18 | Nitro-heterocyclic derivatives |
| PL1974171228A PL93746B1 (enrdf_load_stackoverflow) | 1973-05-19 | 1974-05-18 | |
| AU69158/74A AU487257B2 (en) | 1973-05-19 | 1974-05-20 | 4-hydroxy-3-nitrocarbostyril derivatives and their use in pharmaceutical compositions forthe prophylaxis and treatment of allergic diseases |
| AR253837A AR201506A1 (es) | 1973-05-19 | 1974-05-20 | Procedimiento para preparar derivados de 4-hidroxi-3-nitrocarboestirilo |
| ZA00743196A ZA743196B (en) | 1973-05-19 | 1974-05-20 | Nitro-heterocyclic derivatives |
| DD178631A DD112126A5 (enrdf_load_stackoverflow) | 1973-05-19 | 1974-05-20 | |
| JP49056448A JPS5030884A (enrdf_load_stackoverflow) | 1973-05-19 | 1974-05-20 | |
| PH15854A PH10621A (en) | 1973-05-19 | 1974-05-20 | Anti-allergenic composition containing carbostyril derivatives and method of use |
| ZM79/74A ZM7974A1 (en) | 1973-05-19 | 1974-05-20 | Nitro-heterocyclic derivatives |
| IN1344/CAL/74A IN139603B (enrdf_load_stackoverflow) | 1973-05-19 | 1974-06-18 | |
| US05/545,100 US3962445A (en) | 1973-05-19 | 1975-01-29 | Anti-allergenic carbostyril derivatives |
| NO751554A NO751554L (enrdf_load_stackoverflow) | 1973-05-19 | 1975-04-30 | |
| US05/715,501 US4065457A (en) | 1973-05-19 | 1976-08-18 | 4-Hydroxy-3-nitro-carbostyril compounds |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2400073A GB1453863A (en) | 1973-05-19 | 1973-05-19 | Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity |
| GB2431773 | 1973-05-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1453863A true GB1453863A (en) | 1976-10-27 |
Family
ID=26256830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2400073A Expired GB1453863A (en) | 1973-05-19 | 1973-05-19 | Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity |
Country Status (21)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4192876A (en) * | 1975-07-23 | 1980-03-11 | Sandoz, Inc. | 4-Hydroxy-3-nitro-quinoline-2(1H)-ones |
| US5622965A (en) * | 1993-03-12 | 1997-04-22 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4065457A (en) * | 1973-05-19 | 1977-12-27 | Beecham Group Limited | 4-Hydroxy-3-nitro-carbostyril compounds |
| DE2631317A1 (de) * | 1975-07-23 | 1977-02-17 | Sandoz Ag | Organische verbindungen, ihre verwendung und herstellung |
| JPS5919095B2 (ja) * | 1977-06-22 | 1984-05-02 | 大塚製薬株式会社 | キノリン誘導体及びその製造法 |
| JPH0681744B2 (ja) * | 1986-10-06 | 1994-10-19 | 三菱化成株式会社 | ２，４−ジオキシキノリン誘導体の製造方法 |
-
1973
- 1973-05-19 GB GB2400073A patent/GB1453863A/en not_active Expired
-
1974
- 1974-05-15 IE IE1039/74A patent/IE39269B1/xx unknown
- 1974-05-17 CA CA200,335A patent/CA1030539A/en not_active Expired
- 1974-05-17 SE SE7406631A patent/SE7406631L/xx unknown
- 1974-05-17 NL NL7406711A patent/NL7406711A/xx not_active Application Discontinuation
- 1974-05-17 AT AT409674A patent/AT334373B/de not_active IP Right Cessation
- 1974-05-17 DK DK273074AA patent/DK137043B/da unknown
- 1974-05-17 SU SU7402031653A patent/SU578869A3/ru active
- 1974-05-17 FI FI1531/74A patent/FI153174A7/fi unknown
- 1974-05-17 HU HUBE1198A patent/HU168001B/hu unknown
- 1974-05-17 ES ES426427A patent/ES426427A1/es not_active Expired
- 1974-05-17 CH CH683674A patent/CH601243A5/xx not_active IP Right Cessation
- 1974-05-17 IL IL44849A patent/IL44849A/xx unknown
- 1974-05-17 DE DE2424076A patent/DE2424076A1/de active Pending
- 1974-05-17 FR FR7417170A patent/FR2229414B1/fr not_active Expired
- 1974-05-20 JP JP49056448A patent/JPS5030884A/ja active Pending
- 1974-05-20 PH PH15854A patent/PH10621A/en unknown
- 1974-05-20 ZM ZM79/74A patent/ZM7974A1/xx unknown
- 1974-05-20 AR AR253837A patent/AR201506A1/es active
- 1974-05-20 DD DD178631A patent/DD112126A5/xx unknown
- 1974-06-18 IN IN1344/CAL/74A patent/IN139603B/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4192876A (en) * | 1975-07-23 | 1980-03-11 | Sandoz, Inc. | 4-Hydroxy-3-nitro-quinoline-2(1H)-ones |
| US5622965A (en) * | 1993-03-12 | 1997-04-22 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| SU578869A3 (ru) | 1977-10-30 |
| JPS5030884A (enrdf_load_stackoverflow) | 1975-03-27 |
| ES426427A1 (es) | 1976-09-16 |
| HU168001B (enrdf_load_stackoverflow) | 1976-02-28 |
| DE2424076A1 (de) | 1974-12-05 |
| DK137043C (enrdf_load_stackoverflow) | 1978-06-05 |
| CH601243A5 (enrdf_load_stackoverflow) | 1978-06-30 |
| NL7406711A (enrdf_load_stackoverflow) | 1974-11-21 |
| FR2229414A1 (enrdf_load_stackoverflow) | 1974-12-13 |
| IE39269L (en) | 1974-11-19 |
| AT334373B (de) | 1976-01-10 |
| IL44849A (en) | 1978-04-30 |
| FR2229414B1 (enrdf_load_stackoverflow) | 1977-11-10 |
| FI153174A7 (enrdf_load_stackoverflow) | 1974-11-20 |
| IN139603B (enrdf_load_stackoverflow) | 1976-07-10 |
| DD112126A5 (enrdf_load_stackoverflow) | 1975-03-20 |
| DK137043B (da) | 1978-01-09 |
| PH10621A (en) | 1977-07-19 |
| IE39269B1 (en) | 1978-08-30 |
| ZM7974A1 (en) | 1974-12-20 |
| ATA409674A (de) | 1976-05-15 |
| AR201506A1 (es) | 1975-03-21 |
| SE7406631L (enrdf_load_stackoverflow) | 1974-11-20 |
| CA1030539A (en) | 1978-05-02 |
| AU6915874A (en) | 1975-11-20 |
| IL44849A0 (en) | 1974-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 429A | Application made for amendment of specification (sect. 29/1949) | ||
| 429H | Application (made) for amendment of specification now open to opposition (sect. 29/1949) | ||
| 429D | Case decided by the comptroller ** specification amended (sect. 29/1949) | ||
| SP | Amendment (slips) printed | ||
| PCNP | Patent ceased through non-payment of renewal fee |