GB1445283A - Biphenyl derivatives and pharmaceutical compositions thereof - Google Patents
Biphenyl derivatives and pharmaceutical compositions thereofInfo
- Publication number
- GB1445283A GB1445283A GB3601374A GB3601374A GB1445283A GB 1445283 A GB1445283 A GB 1445283A GB 3601374 A GB3601374 A GB 3601374A GB 3601374 A GB3601374 A GB 3601374A GB 1445283 A GB1445283 A GB 1445283A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compounds
- biphenylyl
- bromo
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- OQEDOBKXZBACBZ-UHFFFAOYSA-N 4-(1-bromoethyl)-2-chloro-1-phenylbenzene Chemical compound ClC1=CC(C(Br)C)=CC=C1C1=CC=CC=C1 OQEDOBKXZBACBZ-UHFFFAOYSA-N 0.000 abstract 1
- PYTPYXCFKXSEFK-UHFFFAOYSA-N 4-(1-bromoethyl)-2-fluoro-1-phenylbenzene Chemical compound FC1=CC(C(Br)C)=CC=C1C1=CC=CC=C1 PYTPYXCFKXSEFK-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 150000001447 alkali salts Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000006267 biphenyl group Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- ABICBQAHHGRVDI-UHFFFAOYSA-N ethyl acetate ethyl 2-[methylidene(diphenyl)-lambda5-phosphanyl]benzoate Chemical compound C(C)OC(=O)C1=C(C=CC=C1)P(C1=CC=CC=C1)(C1=CC=CC=C1)=C.C(C)(=O)OCC ABICBQAHHGRVDI-UHFFFAOYSA-N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732341507 DE2341507A1 (de) | 1973-08-16 | 1973-08-16 | Neue biphenylderivate und verfahren zur herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1445283A true GB1445283A (en) | 1976-08-11 |
Family
ID=5889963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3601374A Expired GB1445283A (en) | 1973-08-16 | 1974-08-15 | Biphenyl derivatives and pharmaceutical compositions thereof |
Country Status (18)
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4371473A (en) | 1979-06-28 | 1983-02-01 | Ethyl Corporation | Preparation of 2-(2-fluoro-4-biphenylyl)propionic acid and corresponding nitride |
| US4422979A (en) | 1980-09-22 | 1983-12-27 | Ethyl Corporation | Fluoro-substituted biphenylyl compounds and processes |
| US4885404A (en) * | 1985-07-12 | 1989-12-05 | The Upjohn Company | Flurbiprofen intermediate |
| US9206143B2 (en) | 2008-03-19 | 2015-12-08 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| US9212155B2 (en) | 2008-03-19 | 2015-12-15 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| US10793515B2 (en) | 2008-03-19 | 2020-10-06 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6100260A (en) * | 1997-04-21 | 2000-08-08 | Sumitomo Pharmaceutical Company, Limited | Isoxazole derivatives |
| DE69832270T2 (de) * | 1997-04-21 | 2006-07-13 | Dainippon Sumitomo Pharma Co., Ltd. | Isoxazolderivate |
-
1973
- 1973-08-16 DE DE19732341507 patent/DE2341507A1/de active Pending
-
1974
- 1974-07-12 AT AT577674A patent/AT331235B/de not_active IP Right Cessation
- 1974-07-31 NL NL7410292A patent/NL7410292A/xx unknown
- 1974-08-02 NO NO742802A patent/NO742802L/no unknown
- 1974-08-12 FI FI2389/74A patent/FI238974A7/fi unknown
- 1974-08-14 DK DK433674A patent/DK433674A/da unknown
- 1974-08-14 RO RO7479779A patent/RO72842A/ro unknown
- 1974-08-14 FR FR7428295A patent/FR2240722B1/fr not_active Expired
- 1974-08-14 HU HUTO977A patent/HU168875B/hu unknown
- 1974-08-14 IL IL45464A patent/IL45464A0/xx unknown
- 1974-08-15 ZA ZA00745257A patent/ZA745257B/xx unknown
- 1974-08-15 SE SE7410436A patent/SE7410436L/xx unknown
- 1974-08-15 GB GB3601374A patent/GB1445283A/en not_active Expired
- 1974-08-15 JP JP49093812A patent/JPS5049262A/ja active Pending
- 1974-08-16 DD DD180557A patent/DD114590A5/xx unknown
- 1974-08-16 BE BE147701A patent/BE818952A/xx unknown
- 1974-08-16 AU AU72430/74A patent/AU7243074A/en not_active Expired
-
1976
- 1976-04-03 ES ES446695A patent/ES446695A1/es not_active Expired
- 1976-04-03 ES ES446690A patent/ES446690A1/es not_active Expired
- 1976-04-03 ES ES446698A patent/ES446698A1/es not_active Expired
- 1976-04-03 ES ES446694A patent/ES446694A1/es not_active Expired
- 1976-04-03 ES ES446693A patent/ES446693A1/es not_active Expired
- 1976-04-03 ES ES446701A patent/ES446701A1/es not_active Expired
- 1976-04-03 ES ES446700A patent/ES446700A1/es not_active Expired
- 1976-04-03 ES ES446699A patent/ES446699A1/es not_active Expired
- 1976-04-03 ES ES76446691A patent/ES446691A1/es not_active Expired
- 1976-04-03 ES ES446689A patent/ES446689A1/es not_active Expired
- 1976-04-03 ES ES446692A patent/ES446692A1/es not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4371473A (en) | 1979-06-28 | 1983-02-01 | Ethyl Corporation | Preparation of 2-(2-fluoro-4-biphenylyl)propionic acid and corresponding nitride |
| US4422979A (en) | 1980-09-22 | 1983-12-27 | Ethyl Corporation | Fluoro-substituted biphenylyl compounds and processes |
| US4885404A (en) * | 1985-07-12 | 1989-12-05 | The Upjohn Company | Flurbiprofen intermediate |
| US9206143B2 (en) | 2008-03-19 | 2015-12-08 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| US9212155B2 (en) | 2008-03-19 | 2015-12-15 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| US10793515B2 (en) | 2008-03-19 | 2020-10-06 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |