GB1475913A - Phenylpropanolamines - Google Patents
PhenylpropanolaminesInfo
- Publication number
- GB1475913A GB1475913A GB4379274A GB4379274A GB1475913A GB 1475913 A GB1475913 A GB 1475913A GB 4379274 A GB4379274 A GB 4379274A GB 4379274 A GB4379274 A GB 4379274A GB 1475913 A GB1475913 A GB 1475913A
- Authority
- GB
- United Kingdom
- Prior art keywords
- protecting group
- reducing
- alkoxy
- formula
- oct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/08—Amines; Quaternary ammonium compounds containing oxygen or sulfur
- A01N33/10—Amines; Quaternary ammonium compounds containing oxygen or sulfur having at least one oxygen or sulfur atom directly attached to an aromatic ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1475913 Phenylpropanolamines BOEHRINGER INGELHEIM GmbH 9 Oct 1974 [11 Oct 1973] 43792/74 Heading C2C Compounds of the general formula (R 1 = H, halogen, CF 3 , OH, C 1-4 alkyl or alkoxy; R 2 = H, C 1-4 alkyl, benzyl) and their salts are prepared by (a) reducing a compound of the formula (R 2 <SP>1</SP> = R 2 , C 1-4 alkanoyl, benzoyl; R 3 =alkoxy, substituted alkoxy) with a complex hydride and, if necessary, deacylating the product, (b) removing the protecting group(s) in a compound of the formula (R 4 = H, protecting group; R 5 = R 1 , OR 7 ; R 6 = R 2 , protecting group; R 7 = protecting group; at least one of M 4,6,7 =protecting group), (c) reducing the corresponding nitropropanol, (d) alkylating or benzylating the primary amine or (e) reducing the corresponding amide, optionally followed by resolution and/or salt formation. The above compounds are sympathicomimetics and increase blood pressure; they may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732351027 DE2351027A1 (en) | 1973-10-11 | 1973-10-11 | PROPANOL DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1475913A true GB1475913A (en) | 1977-06-10 |
Family
ID=5895110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4379274A Expired GB1475913A (en) | 1973-10-11 | 1974-10-09 | Phenylpropanolamines |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5064236A (en) |
| AT (1) | AT343627B (en) |
| BE (1) | BE820938A (en) |
| BG (2) | BG24797A3 (en) |
| CA (1) | CA1041546A (en) |
| CS (2) | CS176293B2 (en) |
| DD (1) | DD115900A5 (en) |
| DE (1) | DE2351027A1 (en) |
| DK (1) | DK138848C (en) |
| ES (4) | ES430420A1 (en) |
| FI (1) | FI282074A (en) |
| FR (1) | FR2247221B1 (en) |
| GB (1) | GB1475913A (en) |
| HU (1) | HU167904B (en) |
| IE (1) | IE40624B1 (en) |
| IL (1) | IL45813A (en) |
| NL (1) | NL7413317A (en) |
| NO (1) | NO139384C (en) |
| PH (1) | PH12476A (en) |
| PL (2) | PL93903B1 (en) |
| RO (2) | RO70259A (en) |
| SE (1) | SE7412790L (en) |
| SU (2) | SU560528A3 (en) |
| ZA (1) | ZA746424B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7371762B2 (en) | 2001-08-27 | 2008-05-13 | Arpida Ag | 3-substituted 6,7-dihydroxytetrahydroisoquinoline derivatives for use as antibacterial agents |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4071552A (en) | 1976-05-19 | 1978-01-31 | Ayerst Mckenna And Harrison Ltd. | Aryloxy aminobutanols, their preparation and use thereof |
| US4170653A (en) | 1976-05-19 | 1979-10-09 | Ayerst McKenna and Harrison Limited | Antidepressant naphthyloxy piperidino and pyrrolidino propanol ethers |
-
1973
- 1973-10-11 DE DE19732351027 patent/DE2351027A1/en active Pending
-
1974
- 1974-09-20 AT AT756274A patent/AT343627B/en not_active IP Right Cessation
- 1974-09-26 FI FI2820/74A patent/FI282074A/fi unknown
- 1974-09-26 ES ES430420A patent/ES430420A1/en not_active Expired
- 1974-09-27 CS CS7031A patent/CS176293B2/cs unknown
- 1974-09-27 CS CS6670A patent/CS176284B2/cs unknown
- 1974-10-03 RO RO7482882A patent/RO70259A/en unknown
- 1974-10-07 SU SU2064398A patent/SU560528A3/en active
- 1974-10-08 RO RO7480152A patent/RO68469A/en unknown
- 1974-10-09 HU HUBO1520A patent/HU167904B/hu unknown
- 1974-10-09 IL IL45813A patent/IL45813A/en unknown
- 1974-10-09 DD DD181592A patent/DD115900A5/xx unknown
- 1974-10-09 BG BG7400033086A patent/BG24797A3/en unknown
- 1974-10-09 JP JP49115688A patent/JPS5064236A/ja active Pending
- 1974-10-09 ZA ZA00746424A patent/ZA746424B/en unknown
- 1974-10-09 BG BG7400027898A patent/BG24796A3/en unknown
- 1974-10-09 GB GB4379274A patent/GB1475913A/en not_active Expired
- 1974-10-10 PL PL1974183237A patent/PL93903B1/pl unknown
- 1974-10-10 PL PL1974174735A patent/PL93938B1/pl unknown
- 1974-10-10 PH PH16396A patent/PH12476A/en unknown
- 1974-10-10 CA CA211,135A patent/CA1041546A/en not_active Expired
- 1974-10-10 NO NO743653A patent/NO139384C/en unknown
- 1974-10-10 IE IE2101/74A patent/IE40624B1/en unknown
- 1974-10-10 DK DK529874A patent/DK138848C/en active
- 1974-10-10 SE SE7412790A patent/SE7412790L/xx unknown
- 1974-10-10 BE BE149420A patent/BE820938A/en unknown
- 1974-10-10 NL NL7413317A patent/NL7413317A/en not_active Application Discontinuation
- 1974-10-11 FR FR7434294A patent/FR2247221B1/fr not_active Expired
-
1975
- 1975-10-23 ES ES442023A patent/ES442023A1/en not_active Expired
- 1975-10-23 ES ES442024A patent/ES442024A1/en not_active Expired
- 1975-10-23 ES ES442022A patent/ES442022A1/en not_active Expired
- 1975-10-28 SU SU752184011A patent/SU586835A3/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7371762B2 (en) | 2001-08-27 | 2008-05-13 | Arpida Ag | 3-substituted 6,7-dihydroxytetrahydroisoquinoline derivatives for use as antibacterial agents |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |