GB1442925A - Triamcinolone derivative - Google Patents
Triamcinolone derivativeInfo
- Publication number
- GB1442925A GB1442925A GB2974874A GB2974874A GB1442925A GB 1442925 A GB1442925 A GB 1442925A GB 2974874 A GB2974874 A GB 2974874A GB 2974874 A GB2974874 A GB 2974874A GB 1442925 A GB1442925 A GB 1442925A
- Authority
- GB
- United Kingdom
- Prior art keywords
- triamcinolone
- derivative
- triamcinolone derivative
- acetalization
- cyclopentanone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical class O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 title abstract 3
- BGTOWKSIORTVQH-UHFFFAOYSA-N cyclopentanone Chemical compound O=C1CCCC1 BGTOWKSIORTVQH-UHFFFAOYSA-N 0.000 abstract 2
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 abstract 1
- IQFJTDLERMTRLJ-QZUYBKCWSA-N [2-[(8s,9r,10s,11s,13s,14s,16r,17s)-9-fluoro-11,16,17-trihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](O)[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O IQFJTDLERMTRLJ-QZUYBKCWSA-N 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 238000006359 acetalization reaction Methods 0.000 abstract 1
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 229960005294 triamcinolone Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38930273A | 1973-08-17 | 1973-08-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1442925A true GB1442925A (en) | 1976-07-14 |
Family
ID=23537694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2974874A Expired GB1442925A (en) | 1973-08-17 | 1974-07-04 | Triamcinolone derivative |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4158055A (enExample) |
| JP (1) | JPS557407B2 (enExample) |
| BE (1) | BE818929A (enExample) |
| CH (1) | CH601353A5 (enExample) |
| CY (1) | CY946A (enExample) |
| DE (1) | DE2437847C3 (enExample) |
| FR (1) | FR2240738B1 (enExample) |
| GB (1) | GB1442925A (enExample) |
| HK (1) | HK44778A (enExample) |
| HU (1) | HU172213B (enExample) |
| IE (1) | IE39738B1 (enExample) |
| IL (1) | IL45200A (enExample) |
| KE (1) | KE2820A (enExample) |
| MY (1) | MY7800234A (enExample) |
| NL (1) | NL184899C (enExample) |
| PH (1) | PH12415A (enExample) |
| ZA (1) | ZA744259B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA763131B (en) * | 1975-05-27 | 1978-01-25 | Syntex Inc | Use of flunisolide to treat respiratory diseases |
| DE10326899A1 (de) * | 2003-06-14 | 2004-12-30 | Beiersdorf Ag | Kosmetische Zubereitungen mit stabilisierten Konservierungsmitteln |
| RU2387646C2 (ru) * | 2003-08-29 | 2010-04-27 | Рэнбакси Лабораториз Лимитед | Ингибиторы фосфодиэстеразы типа-iv |
| WO2005028495A1 (en) * | 2003-09-24 | 2005-03-31 | Glaxo Group Limited | Anti-inflammatory glucocorticoids |
| EP1694655A2 (en) * | 2003-11-26 | 2006-08-30 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
| EP1934219A1 (en) | 2005-09-16 | 2008-06-25 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
| WO2007045979A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
| CA2626628A1 (en) * | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type iv inhibitors |
| US20100029728A1 (en) * | 2006-09-22 | 2010-02-04 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
| AU2007298549A1 (en) * | 2006-09-22 | 2008-03-27 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type-IV |
| US20080207659A1 (en) * | 2007-02-15 | 2008-08-28 | Asit Kumar Chakraborti | Inhibitors of phosphodiesterase type 4 |
| EP2124943A1 (en) * | 2007-03-14 | 2009-12-02 | Ranbaxy Laboratories Limited | Pyrazolo [3, 4-b]pyridine derivatives as phosphodiesterase inhibitors |
| EP2124944B1 (en) * | 2007-03-14 | 2012-02-15 | Ranbaxy Laboratories Limited | Pyrazolo[3,4-b]pyridine derivatives as phosphodiesterase inhibitors |
| EP2111861A1 (en) | 2008-04-21 | 2009-10-28 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type IV inhibitors |
| US8900626B2 (en) | 2011-06-20 | 2014-12-02 | Senju Usa, Inc. | Transdermal drug delivery system and method of using the same |
| CN113698448B (zh) * | 2021-10-29 | 2022-02-22 | 山东谷雨春生物科技有限公司 | 一种安西奈德的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB894810A (en) * | 1959-10-05 | 1962-04-26 | American Cyanamid Co | Aqueous pharmaceutical solutions containing anti-inflammatory steroids |
| US3048581A (en) * | 1960-04-25 | 1962-08-07 | Olin Mathieson | Acetals and ketals of 16, 17-dihydroxy steroids |
| GB928150A (en) * | 1961-02-08 | 1963-06-06 | Upjohn Co | Topical pharmaceutical compositions comprising steroids and flavonoids |
| US3053836A (en) * | 1961-07-14 | 1962-09-11 | Olin Mathieson | Acetals and ketals of 16alpha, 17alpha-dihydroxyprogesterones |
| US3541602A (en) * | 1968-07-29 | 1970-11-17 | Squibb & Sons Inc | Acetonides of 9-halogenated 3beta,11beta,10alpha,17alpha,21-pentahydroxypregnanes |
| GB1382614A (en) * | 1972-01-10 | 1975-02-05 | Squibb & Sons Inc | Steroid compositions |
| US3867528A (en) * | 1973-10-11 | 1975-02-18 | American Cyanamid Co | Steroidal topical cream base |
-
1974
- 1974-07-02 ZA ZA00744259A patent/ZA744259B/xx unknown
- 1974-07-04 GB GB2974874A patent/GB1442925A/en not_active Expired
- 1974-07-04 CY CY946A patent/CY946A/xx unknown
- 1974-07-05 IL IL45200A patent/IL45200A/xx unknown
- 1974-07-26 PH PH16097A patent/PH12415A/en unknown
- 1974-08-06 DE DE2437847A patent/DE2437847C3/de not_active Expired
- 1974-08-07 NL NLAANVRAGE7410613,A patent/NL184899C/xx not_active IP Right Cessation
- 1974-08-09 CH CH1089974A patent/CH601353A5/xx not_active IP Right Cessation
- 1974-08-12 HU HU74AE00000421A patent/HU172213B/hu unknown
- 1974-08-12 FR FR7427912A patent/FR2240738B1/fr not_active Expired
- 1974-08-14 IE IE1704/74A patent/IE39738B1/xx unknown
- 1974-08-16 BE BE147678A patent/BE818929A/xx not_active IP Right Cessation
- 1974-08-16 JP JP9348174A patent/JPS557407B2/ja not_active Expired
-
1976
- 1976-12-28 US US05/754,917 patent/US4158055A/en not_active Expired - Lifetime
-
1978
- 1978-02-28 KE KE2820A patent/KE2820A/xx unknown
- 1978-08-10 HK HK447/78A patent/HK44778A/xx unknown
- 1978-12-30 MY MY234/78A patent/MY7800234A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2437847A1 (de) | 1975-02-27 |
| CH601353A5 (enExample) | 1978-07-14 |
| NL184899B (nl) | 1989-07-03 |
| IL45200A (en) | 1978-08-31 |
| IL45200A0 (en) | 1974-11-29 |
| MY7800234A (en) | 1978-12-31 |
| ZA744259B (en) | 1975-06-25 |
| IE39738B1 (en) | 1978-12-20 |
| FR2240738B1 (enExample) | 1980-04-11 |
| JPS5058211A (enExample) | 1975-05-21 |
| BE818929A (fr) | 1975-02-17 |
| NL184899C (nl) | 1989-12-01 |
| DE2437847B2 (de) | 1980-06-19 |
| HK44778A (en) | 1978-08-18 |
| JPS557407B2 (enExample) | 1980-02-25 |
| CY946A (en) | 1978-06-23 |
| HU172213B (hu) | 1978-07-28 |
| IE39738L (en) | 1975-02-17 |
| AU7073674A (en) | 1976-01-08 |
| US4158055A (en) | 1979-06-12 |
| PH12415A (en) | 1979-02-07 |
| DE2437847C3 (de) | 1981-03-12 |
| NL7410613A (nl) | 1975-02-19 |
| KE2820A (en) | 1978-03-10 |
| FR2240738A1 (enExample) | 1975-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19940703 |