GB1440722A - 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity - Google Patents

2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity

Info

Publication number
GB1440722A
GB1440722A GB3017674A GB3017674A GB1440722A GB 1440722 A GB1440722 A GB 1440722A GB 3017674 A GB3017674 A GB 3017674A GB 3017674 A GB3017674 A GB 3017674A GB 1440722 A GB1440722 A GB 1440722A
Authority
GB
United Kingdom
Prior art keywords
alkyl
hydrogen
alkanoyl
carbamoyl
alkoxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3017674A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1440722A publication Critical patent/GB1440722A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GB3017674A 1973-07-13 1974-07-08 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity Expired GB1440722A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37902273A 1973-07-13 1973-07-13
US46538174A 1974-04-29 1974-04-29

Publications (1)

Publication Number Publication Date
GB1440722A true GB1440722A (en) 1976-06-23

Family

ID=27008442

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3017674A Expired GB1440722A (en) 1973-07-13 1974-07-08 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity

Country Status (18)

Country Link
JP (1) JPS5037791A (no)
AU (1) AU7073174A (no)
BG (1) BG21606A3 (no)
CH (1) CH605919A5 (no)
DD (1) DD112127A5 (no)
DE (1) DE2433397A1 (no)
DK (1) DK342674A (no)
ES (1) ES428107A1 (no)
FI (1) FI193974A (no)
FR (1) FR2236499B1 (no)
GB (1) GB1440722A (no)
IE (1) IE39869B1 (no)
IL (1) IL45158A0 (no)
LU (1) LU70510A1 (no)
NL (1) NL7408705A (no)
NO (1) NO742351L (no)
RO (1) RO63539A (no)
SE (1) SE417316B (no)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082845A (en) 1977-04-25 1978-04-04 Merck & Co., Inc. 3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines
US4091101A (en) * 1977-06-15 1978-05-23 Merck & Co., Inc. 6-(1-Piperazinyl)quinoxaline
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4107309A (en) * 1977-05-23 1978-08-15 American Cyanamid Company Substituted imidazo[1,2-d]-as-triazines
WO2000076984A2 (en) * 1999-05-21 2000-12-21 Biovitrum Ab Novel compounds, their use and preparation
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
JP2003502317A (ja) * 1999-05-21 2003-01-21 ビオヴィトルム・アクチボラゲット 新規化合物、その使用および製造
WO2004000830A1 (en) 2002-06-19 2003-12-31 Biovitrum Ab Novel compounds, their use and preparation
WO2004009586A1 (en) * 2002-07-19 2004-01-29 Biovitrum Ab Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders
WO2005033088A1 (en) * 2003-09-30 2005-04-14 Janssen Pharmaceutica N.V. Quinoxaline compounds
EA007539B1 (ru) * 2002-07-19 2006-10-27 Биовитрум Аб Новые производные пиперазинона для лечения нарушений, связанных с 5-нт2а-рецептором
US8013156B2 (en) 2003-03-19 2011-09-06 Exelixis, Inc. Tie-2 modulators and methods of use

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0094498A3 (en) * 1982-05-06 1985-04-03 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
ES2042395B1 (es) * 1992-02-27 1994-06-16 Promotora Catalana De Inversio Procedimiento para la obtencion de derivados de 2-ciano-3-piperacinilquinoxalinas.
FR2731221B1 (fr) * 1995-03-01 1997-05-30 Pf Medicament Nouveaux derives de l'ethyl-1 dihydro-1, 2 oxo-2 methylamino-3 quinoxaline, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
EP1025097B1 (en) * 1997-10-24 2005-04-27 Neurogen Corporation 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines being dopamine d 4? receptor subtype ligands
AU6242999A (en) * 1998-09-02 2000-03-21 Neurogen Corporation 2-aryl-4-(1-(4-heteroaryl)piperazin-1-yl) methylimidazoles: dopamine d4 receptor subtype ligands
JP4707261B2 (ja) * 2001-05-15 2011-06-22 日本エンバイロケミカルズ株式会社 キノキサリン系化合物および工業用殺菌組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL260335A (no) * 1960-01-22
CH450434A (de) * 1961-12-14 1968-01-31 Ciba Geigy Verfahren zur Herstellung von Diazinen
BE788451A (fr) * 1971-09-08 1973-03-06 Bayer Ag Nouvelles 2-amino-quinoxalines, leur procede de preparation et leur application comme insecticides, acaricides et fongicides
GB1457005A (en) * 1972-11-20 1976-12-01 Pfizer 2-substituted-3-aminoquinoxalines

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082845A (en) 1977-04-25 1978-04-04 Merck & Co., Inc. 3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
FR2388811A1 (fr) * 1977-04-25 1978-11-24 Merck & Co Inc 3-(1-piperazinyl)-pyrido(2,3-b)pyrazines utiles comme medicaments
US4107309A (en) * 1977-05-23 1978-08-15 American Cyanamid Company Substituted imidazo[1,2-d]-as-triazines
US4091101A (en) * 1977-06-15 1978-05-23 Merck & Co., Inc. 6-(1-Piperazinyl)quinoxaline
JP2003502317A (ja) * 1999-05-21 2003-01-21 ビオヴィトルム・アクチボラゲット 新規化合物、その使用および製造
US7534794B2 (en) 1999-05-21 2009-05-19 Biovitrum Ab Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
WO2000076984A2 (en) * 1999-05-21 2000-12-21 Biovitrum Ab Novel compounds, their use and preparation
WO2000076984A3 (en) * 1999-05-21 2001-02-08 Pharmacia & Upjohn Ab Novel compounds, their use and preparation
US7071180B2 (en) 1999-05-21 2006-07-04 Biovitrum Ab Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
WO2004000830A1 (en) 2002-06-19 2003-12-31 Biovitrum Ab Novel compounds, their use and preparation
WO2004009586A1 (en) * 2002-07-19 2004-01-29 Biovitrum Ab Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders
EA007539B1 (ru) * 2002-07-19 2006-10-27 Биовитрум Аб Новые производные пиперазинона для лечения нарушений, связанных с 5-нт2а-рецептором
US7244722B2 (en) 2002-07-19 2007-07-17 Biovitrum Ab Amino-substituted 1H-pyrazin-2-ones and 1H-quinoxalin-2-ones
US8013156B2 (en) 2003-03-19 2011-09-06 Exelixis, Inc. Tie-2 modulators and methods of use
WO2005033088A1 (en) * 2003-09-30 2005-04-14 Janssen Pharmaceutica N.V. Quinoxaline compounds
AU2004278372B2 (en) * 2003-09-30 2010-02-18 Janssen Pharmaceutica N.V. Quinoxaline compounds
CN1886389B (zh) * 2003-09-30 2010-07-21 詹森药业有限公司 喹喔啉化合物

Also Published As

Publication number Publication date
SE417316B (sv) 1981-03-09
FR2236499A1 (no) 1975-02-07
IE39869B1 (en) 1979-01-17
AU7073174A (en) 1976-01-08
ES428107A1 (es) 1976-11-16
NL7408705A (nl) 1975-01-15
NO742351L (no) 1975-02-10
JPS5037791A (no) 1975-04-08
IL45158A0 (en) 1974-11-29
FI193974A (no) 1975-01-14
SE7408486L (sv) 1975-01-14
LU70510A1 (no) 1975-03-27
DE2433397A1 (de) 1975-02-06
DD112127A5 (no) 1975-03-20
RO63539A (fr) 1978-07-15
FR2236499B1 (no) 1977-04-15
DK342674A (no) 1975-03-03
IE39869L (en) 1975-01-13
CH605919A5 (no) 1978-10-13
BG21606A3 (no) 1976-07-20

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee