GB1342753A - Dihydronaphthalene derivatives and higher or lower bicyclo homologues thereof and the preparation thereof - Google Patents

Dihydronaphthalene derivatives and higher or lower bicyclo homologues thereof and the preparation thereof

Info

Publication number
GB1342753A
GB1342753A GB3175471A GB3175471A GB1342753A GB 1342753 A GB1342753 A GB 1342753A GB 3175471 A GB3175471 A GB 3175471A GB 3175471 A GB3175471 A GB 3175471A GB 1342753 A GB1342753 A GB 1342753A
Authority
GB
United Kingdom
Prior art keywords
alkyl
group
alkoxycarbonyl
carboxy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3175471A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Merrell SpA
Original Assignee
Richardson Merrell SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell SpA filed Critical Richardson Merrell SpA
Publication of GB1342753A publication Critical patent/GB1342753A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Abstract

1342753 Diazacyclic compounds RICHARDSON-MERRELL SpA 6 July 1971 [20 July 1970] 31754/71 Heading C2C Novel diazacyclic compounds of the general formula wherein each of R and R 1 is a hydrogen or halogen atom or a trifluoromethyl, C 1-6 alkyl, phenyl, pyridyl, C 1-6 alkoxy, hydroxy, nitro, amino, mono- or di-C 1-6 alkylamino, C 2-7 alkanoylamino, C 2-7 alkoxycarbonyl, carboxy, carbamoyl, sulphamoyl or nitrile group or R and R 1 , when at adjacent positions, may together form a methylenedioxy group, R 2 is a hydrogen atom or a C 1-6 alkyl, phenyl, pyridyl, C 2-7 alkoxycarbonyl, carboxy, carbamoyl or sulphamoyl group, R 3 is a hydrogen atom or a C 1-6 alkyl, phenyl (optionally substituted by halogen atoms or C 1-6 alkyl or C 1-6 alkoxy groups), picolyl, benzyl (optionally substituted by halogen atoms or C 1-6 alkyl or C 1-6 alkoxy groups), alkanoyl, aroyl, cyanoethyl, C 2-7 alkoxycarbonyl, formyl, carboxy, carbethoxyethyl, N - monoalkyl-, N,N - dialkyl. or N- aryl - carbamoylmethyl, N - monoalkyl or N,N - dialkyl - carbamoylethyl, C 3-6 cycloalkyl or methyl-C 3-6 cycloalkyl group, n is 1, 2 or 3, each of A and B is a -Cmq-, -Cmq-Cwx- or -Cmq-Cwx-Cyzgroup, in which each of m, q, w, x, y and z is a hydrogen or halogen atom or a trifluoromethyl, C 1-6 alkyl, C 1-6 alkoxycarbonyl, carboxy, carbamoyl, sulphamoyl, phenyl, pyridyl, benzyl or picolyl group, or m and q, w and x or y and z together form an oxygen atom, and j and k are each 0 or 1, and pharmaceutically acceptable, non-toxic acid-addition salts thereof are prepared (a) by reaction of a ketone and a heterocyclic compound of the respective general formulµ and (b) when R 3 is an alkyl or acyl group, by alkylation or acylation of the corresponding compound in which R 3 is a hydrogen atom; followed optionally by salifaction of the product. Pharmaceutical compositions having analgesic, anti-inflammatory, antipyretic, sedative, myorelaxant, anti-hypertensive, diuretic and chloretic activity comprise, as active ingredient, a diazacyclic compound of the first general formula above or a pharmaceutically acceptable, acid-addition salt thereof, together with a carrier.
GB3175471A 1970-07-20 1971-07-06 Dihydronaphthalene derivatives and higher or lower bicyclo homologues thereof and the preparation thereof Expired GB1342753A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5671270A 1970-07-20 1970-07-20

Publications (1)

Publication Number Publication Date
GB1342753A true GB1342753A (en) 1974-01-03

Family

ID=22006149

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3175471A Expired GB1342753A (en) 1970-07-20 1971-07-06 Dihydronaphthalene derivatives and higher or lower bicyclo homologues thereof and the preparation thereof

Country Status (10)

Country Link
AU (1) AU459326B2 (en)
CA (1) CA969955A (en)
CH (1) CH527198A (en)
DE (1) DE2135458A1 (en)
ES (1) ES393429A1 (en)
FR (1) FR2100935B1 (en)
GB (1) GB1342753A (en)
IL (1) IL37258A (en)
PH (1) PH10173A (en)
ZA (1) ZA714377B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000758A1 (en) * 1977-08-02 1979-02-21 Takeda Chemical Industries, Ltd. Dihydronaphthalene derivatives, their preparation and pharmaceutical compositions

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130646A (en) 1975-07-25 1978-12-19 E. R. Squibb & Sons, Inc. 1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof
DK309678A (en) * 1977-07-18 1979-01-19 Sandoz Ag PROCEDURE FOR THE PREPARATION OF TETRALIN DERIVATIVES
FR2633617B1 (en) * 1988-07-04 1991-02-08 Adir NOVEL BENZOCYCLOHEPTENE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000758A1 (en) * 1977-08-02 1979-02-21 Takeda Chemical Industries, Ltd. Dihydronaphthalene derivatives, their preparation and pharmaceutical compositions

Also Published As

Publication number Publication date
AU459326B2 (en) 1975-03-20
ZA714377B (en) 1972-03-29
DE2135458A1 (en) 1972-01-27
IL37258A0 (en) 1971-10-20
CA969955A (en) 1975-06-24
FR2100935B1 (en) 1975-08-01
FR2100935A1 (en) 1972-03-24
CH527198A (en) 1972-08-31
IL37258A (en) 1975-12-31
AU3138171A (en) 1973-01-25
ES393429A1 (en) 1973-08-16
PH10173A (en) 1976-09-15

Similar Documents

Publication Publication Date Title
GB1222708A (en) Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation
GB1309835A (en) Trialkoxy-quinazolines
GB1351430A (en) Substituted 1,2,4-triazole derivatives
ES8607298A1 (en) Pyrazolopyridine derivatives.
GB1289236A (en)
GB1325529A (en) Aminophenylamidines their production and their medicinal use
GB1342753A (en) Dihydronaphthalene derivatives and higher or lower bicyclo homologues thereof and the preparation thereof
GB1411583A (en) Aminophenyl-substituted alkyl-heterocyclic derivatives and processes for producing them
GB1174051A (en) Aminophenol Derivatives and Analgesic and Antipyretic Compositions
GB1425606A (en) Cyclohexenone derivatives
GB1383255A (en) Quinazolinone derivatives
GB1363195A (en) Propenylamine derivatives and process for the production thereof
GB1336743A (en) S-triazolo-1,5-a- 1,4- benzodiazepine derivatives and a process for their preparation
GB1293507A (en) Derivatives of 3-carbamoyl-2-oxazolidinone, and their process of preparation
GB1152964A (en) Substituted Imidazoline Derivatives
GB1365176A (en) Benzodiazepine derivatives
GB1373367A (en) Hydroxyalkyl substituted 4,5-dihydropyridazin 2h-3-ones
GB1353486A (en) Benzodiazepine derivatives
GB1165603A (en) Alkanoic Acids and their Derivatives
GB1227967A (en)
GB1191565A (en) Substituted Phenoxyalkanoic Acids and their preparation
GB1332697A (en) Benzodiazepine derivatives
GB1203430A (en) Heterocyclic spiro compounds
GB1359224A (en) Triazolobenzodiazepine derivatives
GB1395518A (en) Benzodiazocine derivatives

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees