IE39869B1 - 2-(1'-piperazinyl)-quinoxaline compounds having pharmaceutical activity - Google Patents
2-(1'-piperazinyl)-quinoxaline compounds having pharmaceutical activityInfo
- Publication number
- IE39869B1 IE39869B1 IE1397/74A IE139774A IE39869B1 IE 39869 B1 IE39869 B1 IE 39869B1 IE 1397/74 A IE1397/74 A IE 1397/74A IE 139774 A IE139774 A IE 139774A IE 39869 B1 IE39869 B1 IE 39869B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- hydrogen
- alkanoyl
- carbamoyl
- alkoxycarbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37902273A | 1973-07-13 | 1973-07-13 | |
| US46538174A | 1974-04-29 | 1974-04-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39869L IE39869L (en) | 1975-01-13 |
| IE39869B1 true IE39869B1 (en) | 1979-01-17 |
Family
ID=27008442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1397/74A IE39869B1 (en) | 1973-07-13 | 1974-07-02 | 2-(1'-piperazinyl)-quinoxaline compounds having pharmaceutical activity |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5037791A (no) |
| AU (1) | AU7073174A (no) |
| BG (1) | BG21606A3 (no) |
| CH (1) | CH605919A5 (no) |
| DD (1) | DD112127A5 (no) |
| DE (1) | DE2433397A1 (no) |
| DK (1) | DK342674A (no) |
| ES (1) | ES428107A1 (no) |
| FI (1) | FI193974A (no) |
| FR (1) | FR2236499B1 (no) |
| GB (1) | GB1440722A (no) |
| IE (1) | IE39869B1 (no) |
| IL (1) | IL45158A0 (no) |
| LU (1) | LU70510A1 (no) |
| NL (1) | NL7408705A (no) |
| NO (1) | NO742351L (no) |
| RO (1) | RO63539A (no) |
| SE (1) | SE417316B (no) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
| US4082845A (en) | 1977-04-25 | 1978-04-04 | Merck & Co., Inc. | 3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines |
| US4107309A (en) * | 1977-05-23 | 1978-08-15 | American Cyanamid Company | Substituted imidazo[1,2-d]-as-triazines |
| US4091101A (en) * | 1977-06-15 | 1978-05-23 | Merck & Co., Inc. | 6-(1-Piperazinyl)quinoxaline |
| EP0094498A3 (en) * | 1982-05-06 | 1985-04-03 | American Cyanamid Company | Antiatherosclerotic 1-piperazine derivatives |
| ES2042395B1 (es) * | 1992-02-27 | 1994-06-16 | Promotora Catalana De Inversio | Procedimiento para la obtencion de derivados de 2-ciano-3-piperacinilquinoxalinas. |
| FR2731221B1 (fr) * | 1995-03-01 | 1997-05-30 | Pf Medicament | Nouveaux derives de l'ethyl-1 dihydro-1, 2 oxo-2 methylamino-3 quinoxaline, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant |
| DE69829989T2 (de) * | 1997-10-24 | 2006-02-23 | Neurogen Corp., Branford | 1-(2-naphthyl) und 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazine als dopamin d4 subtype liganden |
| US6040448A (en) | 1997-10-24 | 2000-03-21 | Neurogen Corporation | Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands |
| AU6242999A (en) * | 1998-09-02 | 2000-03-21 | Neurogen Corporation | 2-aryl-4-(1-(4-heteroaryl)piperazin-1-yl) methylimidazoles: dopamine d4 receptor subtype ligands |
| EP1178973B1 (en) * | 1999-05-21 | 2005-12-21 | Biovitrum Ab | Pyrazinyl-piperazine- compounds, their use and preparation |
| US6465467B1 (en) | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
| SE9901884D0 (sv) * | 1999-05-21 | 1999-05-21 | Pharmacia & Upjohn Ab | Novel compounds their use and preparation |
| JP4707261B2 (ja) * | 2001-05-15 | 2011-06-22 | 日本エンバイロケミカルズ株式会社 | キノキサリン系化合物および工業用殺菌組成物 |
| BR0311970A (pt) | 2002-06-19 | 2005-03-29 | Biovitrum Ab | Novos compostos, seu uso e preparação |
| ATE353693T1 (de) | 2002-07-19 | 2007-03-15 | Biovitrum Ab | Neue piperazinyl-pyrazinon-derivate zur behandlung von 5-ht2a rezeptor-bedingten erkrankungen |
| SE0202287D0 (sv) * | 2002-07-19 | 2002-07-19 | Biovitrum Ab | New compounds |
| US8013156B2 (en) | 2003-03-19 | 2011-09-06 | Exelixis, Inc. | Tie-2 modulators and methods of use |
| EP1670774A1 (en) * | 2003-09-30 | 2006-06-21 | Janssen Pharmaceutica N.V. | Quinoxaline compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL260335A (no) * | 1960-01-22 | |||
| CH450434A (de) * | 1961-12-14 | 1968-01-31 | Ciba Geigy | Verfahren zur Herstellung von Diazinen |
| BE788451A (fr) * | 1971-09-08 | 1973-03-06 | Bayer Ag | Nouvelles 2-amino-quinoxalines, leur procede de preparation et leur application comme insecticides, acaricides et fongicides |
| GB1457005A (en) * | 1972-11-20 | 1976-12-01 | Pfizer | 2-substituted-3-aminoquinoxalines |
-
1974
- 1974-06-25 FI FI1939/74A patent/FI193974A/fi unknown
- 1974-06-26 DK DK342674A patent/DK342674A/da unknown
- 1974-06-27 NL NL7408705A patent/NL7408705A/xx not_active Application Discontinuation
- 1974-06-27 SE SE7408486A patent/SE417316B/xx unknown
- 1974-06-27 NO NO742351A patent/NO742351L/no unknown
- 1974-07-01 IL IL45158A patent/IL45158A0/xx unknown
- 1974-07-02 AU AU70731/74A patent/AU7073174A/en not_active Expired
- 1974-07-02 IE IE1397/74A patent/IE39869B1/xx unknown
- 1974-07-08 GB GB3017674A patent/GB1440722A/en not_active Expired
- 1974-07-09 ES ES428107A patent/ES428107A1/es not_active Expired
- 1974-07-11 DD DD179871A patent/DD112127A5/xx unknown
- 1974-07-11 DE DE2433397A patent/DE2433397A1/de active Pending
- 1974-07-11 FR FR7424114A patent/FR2236499B1/fr not_active Expired
- 1974-07-11 LU LU70510A patent/LU70510A1/xx unknown
- 1974-07-12 CH CH964874A patent/CH605919A5/xx not_active IP Right Cessation
- 1974-07-13 RO RO7400079481A patent/RO63539A/ro unknown
- 1974-07-13 BG BG027222A patent/BG21606A3/xx unknown
- 1974-07-13 JP JP49079774A patent/JPS5037791A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU7073174A (en) | 1976-01-08 |
| BG21606A3 (bg) | 1976-07-20 |
| NO742351L (no) | 1975-02-10 |
| JPS5037791A (no) | 1975-04-08 |
| ES428107A1 (es) | 1976-11-16 |
| RO63539A (fr) | 1978-07-15 |
| FR2236499A1 (no) | 1975-02-07 |
| SE7408486L (sv) | 1975-01-14 |
| DK342674A (no) | 1975-03-03 |
| NL7408705A (nl) | 1975-01-15 |
| CH605919A5 (no) | 1978-10-13 |
| DD112127A5 (no) | 1975-03-20 |
| GB1440722A (en) | 1976-06-23 |
| DE2433397A1 (de) | 1975-02-06 |
| IL45158A0 (en) | 1974-11-29 |
| FI193974A (no) | 1975-01-14 |
| SE417316B (sv) | 1981-03-09 |
| FR2236499B1 (no) | 1977-04-15 |
| IE39869L (en) | 1975-01-13 |
| LU70510A1 (no) | 1975-03-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE39869B1 (en) | 2-(1'-piperazinyl)-quinoxaline compounds having pharmaceutical activity | |
| HK1018047A1 (en) | N-(aroyl)glycine hydroxamic acid derivatives and related compounds | |
| MY101268A (en) | Naphthalene derivatives, process for the preparation thereof and pharmaceutical composition containing same | |
| EP0326307A3 (en) | Novel pyridazinone derivatives and pharmaceutical preparations containing them | |
| IL26473A (en) | 4,1-Bis- (4-pyrimidylamino-alkyl) piperazines and process for their production | |
| GB1530412A (en) | Pyrimidinylureas | |
| GB1530413A (en) | 5,8-dihydro-5-oxopyrido(2,3-d)pyrimidines | |
| GB1476698A (en) | Quinazolinone derivatives and therapeutic compositions containing them | |
| DE69223769D1 (en) | Diphenylylchinuclidine als squalen-synthetase-inhibitoren | |
| GB1449861A (en) | Benzodiazepine and benzodiazocine derivatives | |
| GB1299151A (en) | 7-phenylpyrimido-benzodiazepine derivatives | |
| US3784693A (en) | 3-substituted phenyl-quinazoline-4(3h)-ones as sedative hypnotics | |
| GB1361368A (en) | Pyrido 4,3-c pyridazine compounds | |
| GB1515063A (en) | Antibacterial quinoxaline 1,4-dioxides | |
| DE3666588D1 (en) | Spiroûbenzofuran-2(3h), 1'cycloheptane¨s, a process and intermediates for their preparation and their use as medicaments | |
| GB1334125A (en) | Aminopropionanilides and a process for the preparation thereof | |
| GB1325280A (en) | 3-substituted-as-triazino-5,6-c-quinolines | |
| GB1327552A (en) | 1-substituted benzyl tetrahydro-2-1h-pyrimidones and their preparation | |
| IE42230L (en) | Pharmaceutical combination preparation | |
| GB1389531A (en) | Benzotriazocine derivatives and process for the preparation thereof | |
| GB1505859A (en) | Azetidinone derivatives | |
| GB1426978A (en) | Pyrazolodiazocine compounds and methods for their production | |
| EP0919233B8 (en) | Therapeutic agent for kidney diseases | |
| GB1438180A (en) | 1,2,4-benzotriazine derivatives their production and their pharmaceutical and veterinary use | |
| GB1497827A (en) | Triazolobenzodiazepine derivatives |