GB1407971A - 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor - Google Patents

2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor

Info

Publication number
GB1407971A
GB1407971A GB963971A GB963971A GB1407971A GB 1407971 A GB1407971 A GB 1407971A GB 963971 A GB963971 A GB 963971A GB 963971 A GB963971 A GB 963971A GB 1407971 A GB1407971 A GB 1407971A
Authority
GB
United Kingdom
Prior art keywords
triethoxybenzyl
diamino
pyrimidine
methods
preparation therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB963971A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB963971A priority Critical patent/GB1407971A/en
Priority to DE19722218220 priority patent/DE2218220A1/de
Priority to BE782153A priority patent/BE782153A/xx
Priority to DK184372AA priority patent/DK131466B/da
Priority to SE7204847A priority patent/SE391180B/xx
Priority to FR7213215A priority patent/FR2133752B1/fr
Priority to CH554572A priority patent/CH565160A5/xx
Priority to NL7205043A priority patent/NL7205043A/xx
Priority to CA139,774A priority patent/CA967964A/en
Priority to CS7200002539A priority patent/CS181221B2/cs
Priority to AU41174/72A priority patent/AU468447B2/en
Priority to IL47921A priority patent/IL47921A/en
Priority to JP3763772A priority patent/JPS5320511B1/ja
Priority to IL39218A priority patent/IL39218A/en
Priority to CA180,135A priority patent/CA967963A/en
Priority to IL47921A priority patent/IL47921A0/xx
Publication of GB1407971A publication Critical patent/GB1407971A/en
Priority to AU10746/76A priority patent/AU1074676A/en
Priority to JP15503777A priority patent/JPS53111083A/ja
Priority to JP15503677A priority patent/JPS5430189A/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
GB963971A 1971-04-10 1971-04-16 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor Expired GB1407971A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
GB963971A GB1407971A (en) 1971-04-16 1971-04-16 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor
CS7200002539A CS181221B2 (en) 1971-04-16 1972-04-14 Method of producing 2,4-diamino-5-/3,4,5-triethoxybenzyl/-pyrimidine
AU41174/72A AU468447B2 (en) 1971-04-10 1972-04-14 2, 4-diamino-5-benzyl-pyrimidines
DK184372AA DK131466B (da) 1971-04-16 1972-04-14 Analogifremgangsmåde til fremstilling af 2,4-diamino-5-(3,4,5-triethoxybenzyl)-pyrimidin eller salte heraf.
SE7204847A SE391180B (sv) 1971-04-16 1972-04-14 Sett att framstella 2,4-diamino-5-(3',4',5'-trietoxibensyl)-pyrimidiner
FR7213215A FR2133752B1 (enrdf_load_stackoverflow) 1971-04-16 1972-04-14
CH554572A CH565160A5 (enrdf_load_stackoverflow) 1971-04-16 1972-04-14
NL7205043A NL7205043A (enrdf_load_stackoverflow) 1971-04-16 1972-04-14
CA139,774A CA967964A (en) 1971-04-16 1972-04-14 2,4-diamino-5-(3,4,5-triethoxybenzyl) pyrimidine
DE19722218220 DE2218220A1 (de) 1971-04-16 1972-04-14 2.4-Diamino-5-benzylpyrimidine, Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen
BE782153A BE782153A (fr) 1971-04-16 1972-04-14 Composes organiques
IL47921A IL47921A (en) 1971-04-16 1972-04-14 Alpha-(3,4,5-triethoxybenzyl)-acrylonitrile and-propionitrile derivatives and their preparation
JP3763772A JPS5320511B1 (enrdf_load_stackoverflow) 1971-04-16 1972-04-14
IL39218A IL39218A (en) 1971-04-16 1972-04-14 2,4-diamino-5-(3,4,5-triethoxybenzyl) pyrimidine its preparation and pharmaceutical compositions containing it
CA180,135A CA967963A (en) 1971-04-16 1973-08-31 Intermediates in the preparation of 2,4-diamino-5-benzylpyrimidines
IL47921A IL47921A0 (en) 1971-04-16 1975-08-14 New alpha-(3,4,5-triethoxybenzyl)-acrylonitrile and-propionitrile derivatives and their preparation
AU10746/76A AU1074676A (en) 1971-04-16 1976-02-02 3, 4, 5-triethoxy-benzyl nitriles
JP15503777A JPS53111083A (en) 1971-04-16 1977-12-22 Method of producing 2*44diaminoo55benzyll pyrimidine derivative
JP15503677A JPS5430189A (en) 1971-04-16 1977-12-22 Production of 2*44diaminoo 55benzylpyrimidine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB963971A GB1407971A (en) 1971-04-16 1971-04-16 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor

Publications (1)

Publication Number Publication Date
GB1407971A true GB1407971A (en) 1975-10-01

Family

ID=9875880

Family Applications (1)

Application Number Title Priority Date Filing Date
GB963971A Expired GB1407971A (en) 1971-04-10 1971-04-16 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor

Country Status (13)

Country Link
JP (3) JPS5320511B1 (enrdf_load_stackoverflow)
AU (1) AU468447B2 (enrdf_load_stackoverflow)
BE (1) BE782153A (enrdf_load_stackoverflow)
CA (1) CA967964A (enrdf_load_stackoverflow)
CH (1) CH565160A5 (enrdf_load_stackoverflow)
CS (1) CS181221B2 (enrdf_load_stackoverflow)
DE (1) DE2218220A1 (enrdf_load_stackoverflow)
DK (1) DK131466B (enrdf_load_stackoverflow)
FR (1) FR2133752B1 (enrdf_load_stackoverflow)
GB (1) GB1407971A (enrdf_load_stackoverflow)
IL (3) IL47921A (enrdf_load_stackoverflow)
NL (1) NL7205043A (enrdf_load_stackoverflow)
SE (1) SE391180B (enrdf_load_stackoverflow)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA738760B (en) * 1972-12-21 1974-08-28 Hoffmann La Roche Process for the manufacture of benzyl pyrimidines
GB1469521A (en) * 1973-01-05 1977-04-06 Wellcome Found Antimicrobial preparations
FR2502152A1 (fr) * 1981-03-20 1982-09-24 Panmedica Laboratoires Nouveaux derives solubles n2 substitues de la diamino-2,4-benzyl-5-pyrimidines, leur procede de preparation et medicaments les contenant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1090394A (fr) * 1953-03-11 1955-03-30 Wellcome Found Dérivés de pyrimidine et leur fabrication
FR1459417A (fr) * 1964-11-12 1966-04-29 Hoffmann La Roche Procédé pour la préparation de dérivés de pyrimidine
FR1518635A (fr) * 1965-07-08 1968-03-29 Wellcome Found Procédé de préparation de dérivés de la pyrimidine
GB1261455A (en) * 1969-03-06 1972-01-26 Burroughs Wellcome Co Improvements in or relating to substituted acrylonitriles

Also Published As

Publication number Publication date
IL39218A0 (en) 1972-06-28
JPS5422994B2 (enrdf_load_stackoverflow) 1979-08-10
IL47921A (en) 1976-10-31
AU468447B2 (en) 1976-01-15
FR2133752B1 (enrdf_load_stackoverflow) 1975-04-25
BE782153A (fr) 1972-10-16
JPS5430189A (en) 1979-03-06
NL7205043A (enrdf_load_stackoverflow) 1972-10-18
DE2218220A1 (de) 1972-11-02
SE391180B (sv) 1977-02-07
DK131466C (enrdf_load_stackoverflow) 1975-12-08
CS181221B2 (en) 1978-03-31
FR2133752A1 (enrdf_load_stackoverflow) 1972-12-01
JPS5320511B1 (enrdf_load_stackoverflow) 1978-06-27
JPS53111083A (en) 1978-09-28
IL47921A0 (en) 1975-11-25
CA967964A (en) 1975-05-20
CH565160A5 (enrdf_load_stackoverflow) 1975-08-15
IL39218A (en) 1976-10-31
AU4117472A (en) 1973-10-18
DK131466B (da) 1975-07-21

Similar Documents

Publication Publication Date Title
GB1192768A (en) N-Substituted 2,3,4,5,-Tetrahydro-1H-3-Benzazepines
GB1407971A (en) 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor
GB1339748A (en) Pyrimidine derivatives
GB1256849A (enrdf_load_stackoverflow)
GB1350710A (en) Ureas and thioureas
GB1230663A (enrdf_load_stackoverflow)
GB1168430A (en) Improvements in or relating to Nitrofuryl Quinazolines
IL40458A0 (en) Novel pyrimidinones and hydroxypyrimidines,their preparation and pharmaceutical compositions containing them
CA984849A (en) Metal complexes of n,n'-dialkylesters of ethylenedinitrilotetraacetic acid and compositions stabilized thereby
GB1281719A (en) Anti-haemorrhoidally active preparations for local or rectal administration
GB1263929A (en) 2-substituted-4,5-diphenyl-oxazoles
GB1132583A (en) Pharmaceutical compositions containing cephalosporins
GB1518391A (en) Anti-tumour composition
GB1395929A (en) Thioureas
GB1230705A (enrdf_load_stackoverflow)
ES386130A1 (es) Un procedimiento para preparar acido 2-(alfa - (p-clorofe- noxi) - isobutiril)-aminoetanosulfonico o su sal fisiologi- camente compatible.
GB1394702A (en) Pharmacologically active isoquinoline derivatives
ES424636A1 (es) Un procedimiento para la preparacion de sales mixtas en es-teres polisulfuricos de glicopeptidos.
GB1406307A (en) Production of benzylpyrimidines
GB1164135A (en) Pharmaceutical Compositions Comprising Methdilazine Sulphoxide
GB1421323A (en) Pharmaceutical compositions containing sodium tri-n-propylacetate
GB1265930A (enrdf_load_stackoverflow)
GB1259752A (en) Indole derivatives
GB1297043A (enrdf_load_stackoverflow)
GB1306976A (en) Pharmaceutical compositions for reducing serum cholesterol

Legal Events

Date Code Title Description
416 Proceeding under section 16 patents act 1949
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee