JPS5430189A - Production of 2*44diaminoo 55benzylpyrimidine derivative - Google Patents

Production of 2*44diaminoo 55benzylpyrimidine derivative

Info

Publication number
JPS5430189A
JPS5430189A JP15503677A JP15503677A JPS5430189A JP S5430189 A JPS5430189 A JP S5430189A JP 15503677 A JP15503677 A JP 15503677A JP 15503677 A JP15503677 A JP 15503677A JP S5430189 A JPS5430189 A JP S5430189A
Authority
JP
Japan
Prior art keywords
44diaminoo
derivative
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15503677A
Other languages
Japanese (ja)
Other versions
JPS5422994B2 (en
Inventor
Roosu Baabara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of JPS5430189A publication Critical patent/JPS5430189A/en
Publication of JPS5422994B2 publication Critical patent/JPS5422994B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP15503677A 1971-04-16 1977-12-22 Production of 2*44diaminoo 55benzylpyrimidine derivative Granted JPS5430189A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB963971A GB1407971A (en) 1971-04-16 1971-04-16 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor

Publications (2)

Publication Number Publication Date
JPS5430189A true JPS5430189A (en) 1979-03-06
JPS5422994B2 JPS5422994B2 (en) 1979-08-10

Family

ID=9875880

Family Applications (3)

Application Number Title Priority Date Filing Date
JP3763772A Pending JPS5320511B1 (en) 1971-04-16 1972-04-14
JP15503777A Pending JPS53111083A (en) 1971-04-16 1977-12-22 Method of producing 2*44diaminoo55benzyll pyrimidine derivative
JP15503677A Granted JPS5430189A (en) 1971-04-16 1977-12-22 Production of 2*44diaminoo 55benzylpyrimidine derivative

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP3763772A Pending JPS5320511B1 (en) 1971-04-16 1972-04-14
JP15503777A Pending JPS53111083A (en) 1971-04-16 1977-12-22 Method of producing 2*44diaminoo55benzyll pyrimidine derivative

Country Status (13)

Country Link
JP (3) JPS5320511B1 (en)
AU (1) AU468447B2 (en)
BE (1) BE782153A (en)
CA (1) CA967964A (en)
CH (1) CH565160A5 (en)
CS (1) CS181221B2 (en)
DE (1) DE2218220A1 (en)
DK (1) DK131466B (en)
FR (1) FR2133752B1 (en)
GB (1) GB1407971A (en)
IL (3) IL47921A (en)
NL (1) NL7205043A (en)
SE (1) SE391180B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57169472A (en) * 1981-03-20 1982-10-19 Panmedica Sa Novel soluble n2 substituted derivative of 2,4-diamino-5-benzylpyrimidine, manufacture and drug containing same

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA738760B (en) * 1972-12-21 1974-08-28 Hoffmann La Roche Process for the manufacture of benzyl pyrimidines
GB1469521A (en) * 1973-01-05 1977-04-06 Wellcome Found Antimicrobial preparations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1090394A (en) * 1953-03-11 1955-03-30 Wellcome Found Pyrimidine derivatives and their manufacture
FR1459417A (en) * 1964-11-12 1966-04-29 Hoffmann La Roche Process for the preparation of pyrimidine derivatives
FR1518635A (en) * 1965-07-08 1968-03-29 Wellcome Found Process for the preparation of pyrimidine derivatives
GB1261455A (en) * 1969-03-06 1972-01-26 Burroughs Wellcome Co Improvements in or relating to substituted acrylonitriles

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57169472A (en) * 1981-03-20 1982-10-19 Panmedica Sa Novel soluble n2 substituted derivative of 2,4-diamino-5-benzylpyrimidine, manufacture and drug containing same
JPH0340026B2 (en) * 1981-03-20 1991-06-17

Also Published As

Publication number Publication date
CS181221B2 (en) 1978-03-31
DK131466C (en) 1975-12-08
IL47921A0 (en) 1975-11-25
NL7205043A (en) 1972-10-18
IL47921A (en) 1976-10-31
IL39218A0 (en) 1972-06-28
DK131466B (en) 1975-07-21
IL39218A (en) 1976-10-31
FR2133752B1 (en) 1975-04-25
AU4117472A (en) 1973-10-18
GB1407971A (en) 1975-10-01
SE391180B (en) 1977-02-07
CH565160A5 (en) 1975-08-15
CA967964A (en) 1975-05-20
DE2218220A1 (en) 1972-11-02
JPS5320511B1 (en) 1978-06-27
JPS5422994B2 (en) 1979-08-10
FR2133752A1 (en) 1972-12-01
AU468447B2 (en) 1976-01-15
BE782153A (en) 1972-10-16
JPS53111083A (en) 1978-09-28

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