JPS53111083A - Method of producing 2*44diaminoo55benzyll pyrimidine derivative - Google Patents

Method of producing 2*44diaminoo55benzyll pyrimidine derivative

Info

Publication number
JPS53111083A
JPS53111083A JP15503777A JP15503777A JPS53111083A JP S53111083 A JPS53111083 A JP S53111083A JP 15503777 A JP15503777 A JP 15503777A JP 15503777 A JP15503777 A JP 15503777A JP S53111083 A JPS53111083 A JP S53111083A
Authority
JP
Japan
Prior art keywords
producing
pyrimidine derivative
pyrimidine
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15503777A
Other languages
Japanese (ja)
Inventor
Roosu Baabara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of JPS53111083A publication Critical patent/JPS53111083A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP15503777A 1971-04-16 1977-12-22 Method of producing 2*44diaminoo55benzyll pyrimidine derivative Pending JPS53111083A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB963971A GB1407971A (en) 1971-04-16 1971-04-16 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor

Publications (1)

Publication Number Publication Date
JPS53111083A true JPS53111083A (en) 1978-09-28

Family

ID=9875880

Family Applications (3)

Application Number Title Priority Date Filing Date
JP3763772A Pending JPS5320511B1 (en) 1971-04-16 1972-04-14
JP15503677A Granted JPS5430189A (en) 1971-04-16 1977-12-22 Production of 2*44diaminoo 55benzylpyrimidine derivative
JP15503777A Pending JPS53111083A (en) 1971-04-16 1977-12-22 Method of producing 2*44diaminoo55benzyll pyrimidine derivative

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP3763772A Pending JPS5320511B1 (en) 1971-04-16 1972-04-14
JP15503677A Granted JPS5430189A (en) 1971-04-16 1977-12-22 Production of 2*44diaminoo 55benzylpyrimidine derivative

Country Status (13)

Country Link
JP (3) JPS5320511B1 (en)
AU (1) AU468447B2 (en)
BE (1) BE782153A (en)
CA (1) CA967964A (en)
CH (1) CH565160A5 (en)
CS (1) CS181221B2 (en)
DE (1) DE2218220A1 (en)
DK (1) DK131466B (en)
FR (1) FR2133752B1 (en)
GB (1) GB1407971A (en)
IL (3) IL39218A (en)
NL (1) NL7205043A (en)
SE (1) SE391180B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA738760B (en) * 1972-12-21 1974-08-28 Hoffmann La Roche Process for the manufacture of benzyl pyrimidines
GB1469521A (en) * 1973-01-05 1977-04-06 Wellcome Found Antimicrobial preparations
FR2502152A1 (en) * 1981-03-20 1982-09-24 Panmedica Laboratoires NOVEL SUBSTITUTED DIAMINO-2,4-BENZYL-5-PYRIMIDINE N2-SOLUBLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING SAME

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1090394A (en) * 1953-03-11 1955-03-30 Wellcome Found Pyrimidine derivatives and their manufacture
FR1459417A (en) * 1964-11-12 1966-04-29 Hoffmann La Roche Process for the preparation of pyrimidine derivatives
FR1518635A (en) * 1965-07-08 1968-03-29 Wellcome Found Process for the preparation of pyrimidine derivatives
GB1261455A (en) * 1969-03-06 1972-01-26 Burroughs Wellcome Co Improvements in or relating to substituted acrylonitriles

Also Published As

Publication number Publication date
NL7205043A (en) 1972-10-18
SE391180B (en) 1977-02-07
CS181221B2 (en) 1978-03-31
JPS5320511B1 (en) 1978-06-27
IL47921A (en) 1976-10-31
JPS5430189A (en) 1979-03-06
DK131466B (en) 1975-07-21
IL39218A0 (en) 1972-06-28
JPS5422994B2 (en) 1979-08-10
CH565160A5 (en) 1975-08-15
AU4117472A (en) 1973-10-18
DK131466C (en) 1975-12-08
DE2218220A1 (en) 1972-11-02
AU468447B2 (en) 1976-01-15
CA967964A (en) 1975-05-20
FR2133752A1 (en) 1972-12-01
IL39218A (en) 1976-10-31
FR2133752B1 (en) 1975-04-25
BE782153A (en) 1972-10-16
IL47921A0 (en) 1975-11-25
GB1407971A (en) 1975-10-01

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