GB1397680A - Aqueous lipid emulsion for parenteral alimentation - Google Patents
Aqueous lipid emulsion for parenteral alimentationInfo
- Publication number
- GB1397680A GB1397680A GB5881973A GB5881973A GB1397680A GB 1397680 A GB1397680 A GB 1397680A GB 5881973 A GB5881973 A GB 5881973A GB 5881973 A GB5881973 A GB 5881973A GB 1397680 A GB1397680 A GB 1397680A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- lipid emulsion
- adjuster
- emulsifier
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002960 lipid emulsion Substances 0.000 title abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 239000003797 essential amino acid Substances 0.000 abstract 3
- 235000020776 essential amino acid Nutrition 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 235000010469 Glycine max Nutrition 0.000 abstract 2
- 244000068988 Glycine max Species 0.000 abstract 2
- 239000003995 emulsifying agent Substances 0.000 abstract 2
- 235000015097 nutrients Nutrition 0.000 abstract 2
- 239000003002 pH adjusting agent Substances 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 229940024606 amino acid Drugs 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 235000012343 cottonseed oil Nutrition 0.000 abstract 1
- 239000002385 cottonseed oil Substances 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 235000019198 oils Nutrition 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7301705A FR2215212B1 (enrdf_load_stackoverflow) | 1973-01-18 | 1973-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1397680A true GB1397680A (en) | 1975-06-18 |
Family
ID=9113474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5881973A Expired GB1397680A (en) | 1973-01-18 | 1973-12-19 | Aqueous lipid emulsion for parenteral alimentation |
Country Status (12)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0047647A3 (en) * | 1980-09-04 | 1982-09-15 | Ed. Geistlich Sohne A.G. Fur Chemische Industrie | Pharmaceutical compositions for promoting the healing of wounds |
| GB2216418A (en) * | 1988-03-09 | 1989-10-11 | Biorex Kft | Antiviral and immunostimulating compositions comprising amino acids and polyunsaturated higher fatty acids. |
| GB2297485A (en) * | 1995-02-03 | 1996-08-07 | Mini Agriculture & Fisheries | Amino acid compositions |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2530246A1 (de) * | 1975-07-07 | 1977-01-13 | Fresenius Chem Pharm Ind | L-aminosaeuregemische fuer parenterale oder orale anwendung |
| DE2531201C2 (de) * | 1975-07-12 | 1986-05-28 | Fresenius AG, 6380 Bad Homburg | Aminosäure-Infusionslösungen für die Verwendung bei Frühgeburten bis Kleinkindern |
| DE2531204C2 (de) * | 1975-07-12 | 1987-01-22 | Fresenius AG, 6380 Bad Homburg | L-Aminosäuregemische für die parenterale oder orale Ernährung |
| DE2642768A1 (de) * | 1976-09-23 | 1978-03-30 | Fresenius Chem Pharm Ind | Essentielle und nicht essentielle l-aminosaeuren enthaltendes gemisch zur behandlung von leberinsuffizienz |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2662046A (en) * | 1948-06-19 | 1953-12-08 | Merck & Co Inc | Parenteral amino acid solution |
| US3080234A (en) * | 1960-12-06 | 1963-03-05 | Pfizer & Co C | Method of improving the efficiency of amino acid diets |
| AT297935B (de) * | 1968-05-09 | 1972-04-10 | Astra Ab | Verfahren zur Herstellung einer Infusionslösung von essentiellen Aminosäuren zur intravenösen Zufuhr bei urämischen Zuständen |
| DE1792294B1 (de) * | 1968-08-16 | 1970-07-09 | Braun Fa B | Verfahren zur Herstellung stabiler,nicht pyrogener,intravenoes applizierbarer,waessriger aminosaeurehaltiger Fettemulsionen |
| DE1934317B1 (de) * | 1969-07-07 | 1970-10-15 | Braun Fa B | Verfahren zur Herstellung stabiler,nicht pyrogener,intravenoes applizierbarer,waessriger aminosaeurehaltiger Fettemulsionen |
| ES392481A1 (es) * | 1970-06-29 | 1975-03-01 | Procter & Gamble | Procedimiento para la formacion de emulsiones estables uti-les en la preparacion de productos alimenticios. |
-
1973
- 1973-01-18 FR FR7301705A patent/FR2215212B1/fr not_active Expired
- 1973-01-25 DE DE2303463A patent/DE2303463C2/de not_active Expired
- 1973-12-17 CH CH1763573A patent/CH574716A5/xx not_active IP Right Cessation
- 1973-12-18 IE IE2289/73A patent/IE38651B1/xx unknown
- 1973-12-19 GB GB5881973A patent/GB1397680A/en not_active Expired
- 1973-12-19 BE BE139028A patent/BE808823A/xx not_active IP Right Cessation
- 1973-12-21 ZA ZA739667A patent/ZA739667B/xx unknown
- 1973-12-21 AU AU63920/73A patent/AU476180B2/en not_active Expired
-
1974
- 1974-01-15 SE SE7400470A patent/SE422152B/xx not_active IP Right Cessation
- 1974-01-16 DK DK22774AA patent/DK134097B/da not_active IP Right Cessation
- 1974-01-17 NL NL7400673A patent/NL7400673A/xx active Search and Examination
- 1974-01-17 ES ES422537A patent/ES422537A1/es not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0047647A3 (en) * | 1980-09-04 | 1982-09-15 | Ed. Geistlich Sohne A.G. Fur Chemische Industrie | Pharmaceutical compositions for promoting the healing of wounds |
| GB2216418A (en) * | 1988-03-09 | 1989-10-11 | Biorex Kft | Antiviral and immunostimulating compositions comprising amino acids and polyunsaturated higher fatty acids. |
| GB2216418B (en) * | 1988-03-09 | 1991-12-11 | Biorex Kft | Antiviral and immunostimulating pharmaceutical compositions and process for preparing same |
| GB2297485A (en) * | 1995-02-03 | 1996-08-07 | Mini Agriculture & Fisheries | Amino acid compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2215212A1 (enrdf_load_stackoverflow) | 1974-08-23 |
| FR2215212B1 (enrdf_load_stackoverflow) | 1976-03-05 |
| ZA739667B (en) | 1974-11-27 |
| IE38651B1 (en) | 1978-04-26 |
| IE38651L (en) | 1974-07-18 |
| DE2303463C2 (de) | 1986-05-28 |
| AU6392073A (en) | 1975-06-26 |
| CH574716A5 (enrdf_load_stackoverflow) | 1976-04-30 |
| DE2303463A1 (de) | 1974-07-25 |
| AU476180B2 (en) | 1976-09-16 |
| DK134097B (da) | 1976-09-13 |
| DK134097C (enrdf_load_stackoverflow) | 1977-02-14 |
| SE422152B (sv) | 1982-02-22 |
| ES422537A1 (es) | 1976-05-01 |
| NL7400673A (enrdf_load_stackoverflow) | 1974-07-22 |
| BE808823A (fr) | 1974-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19931218 |