GB1397073A - 1,2,4-oxadizoles - Google Patents
1,2,4-oxadizolesInfo
- Publication number
- GB1397073A GB1397073A GB1583871A GB1583871A GB1397073A GB 1397073 A GB1397073 A GB 1397073A GB 1583871 A GB1583871 A GB 1583871A GB 1583871 A GB1583871 A GB 1583871A GB 1397073 A GB1397073 A GB 1397073A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbamoyl group
- araliphatic
- conr
- cycloaliphatic
- defined above
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000844 anti-bacterial effect Effects 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 N-substituted carbamoyl group Chemical group 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000002141 anti-parasite Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003096 antiparasitic agent Substances 0.000 abstract 1
- VQODGRNSFPNSQE-DVTGEIKXSA-N betamethasone phosphate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COP(O)(O)=O)(O)[C@@]1(C)C[C@@H]2O VQODGRNSFPNSQE-DVTGEIKXSA-N 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003889 eye drop Substances 0.000 abstract 1
- 229940012356 eye drops Drugs 0.000 abstract 1
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000007922 nasal spray Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1583871A GB1397073A (en) | 1971-05-19 | 1971-05-19 | 1,2,4-oxadizoles |
| FR7217790A FR2138079B1 (enrdf_load_stackoverflow) | 1971-05-19 | 1972-05-18 | |
| BE783653A BE783653A (fr) | 1971-05-19 | 1972-05-18 | Nouveaux derives du 1,2,4-oxadiazole et compositions pharmaceutiques, qui les contiennent |
| DE19722224338 DE2224338A1 (de) | 1971-05-19 | 1972-05-18 | Oxadiazol Derivate |
| NL7206759A NL7206759A (enrdf_load_stackoverflow) | 1971-05-19 | 1972-05-18 | |
| ZA723387A ZA723387B (en) | 1971-05-19 | 1972-05-18 | New oxadiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same |
| US05/415,342 US3991067A (en) | 1971-05-19 | 1973-11-13 | Mono- or disubstituted 1,2,4,oxadiazoles which are substituted by at least 1-N-substituted carbamoyl group |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1583871A GB1397073A (en) | 1971-05-19 | 1971-05-19 | 1,2,4-oxadizoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1397073A true GB1397073A (en) | 1975-06-11 |
Family
ID=10066433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1583871A Expired GB1397073A (en) | 1971-05-19 | 1971-05-19 | 1,2,4-oxadizoles |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE783653A (enrdf_load_stackoverflow) |
| DE (1) | DE2224338A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2138079B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1397073A (enrdf_load_stackoverflow) |
| NL (1) | NL7206759A (enrdf_load_stackoverflow) |
| ZA (1) | ZA723387B (enrdf_load_stackoverflow) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996016080A1 (en) * | 1994-11-21 | 1996-05-30 | Cortech, Inc. | Human neutrophil elastase inhibitors |
| US5998379A (en) * | 1994-11-21 | 1999-12-07 | Cortech Inc. | Serine protease inhibitors-proline analogs |
| US6001811A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Serine protease inhibitors--N-substituted derivatives |
| US6001814A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Serine protease inhibitors |
| US6001813A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Val-pro containing α-keto oxadiazoles as serine protease inhibitors |
| US6015791A (en) * | 1994-11-21 | 2000-01-18 | Cortech Inc. | Serine protease inhibitors-cycloheptane derivatives |
| US6100238A (en) * | 1994-11-21 | 2000-08-08 | Cortech Inc. | Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors |
| US6150334A (en) * | 1994-11-21 | 2000-11-21 | Cortech, Inc. | Serine protease inhibitors-tripeptoid analogs |
| US6159938A (en) * | 1994-11-21 | 2000-12-12 | Cortech, Inc. | Serine protease inhibitors comprising α-keto heterocycles |
| US6548638B2 (en) | 1998-06-03 | 2003-04-15 | Cortech, Inc. | Peptoid and nonpeptoid containing α-keto oxadiazoles as serine protease inhibitors |
| US6608175B2 (en) | 1994-11-21 | 2003-08-19 | Cortech, Inc. | Serine protease inhibitors |
| US6656910B2 (en) | 1997-12-04 | 2003-12-02 | Cortech, Inc. | Serine protease inhibitors |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8207205B2 (en) * | 2008-04-21 | 2012-06-26 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
| US8343976B2 (en) | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1357733A (en) * | 1970-07-28 | 1974-06-26 | Glaxo Lab Ltd | 1,2,4-oxadiazole derivatives |
-
1971
- 1971-05-19 GB GB1583871A patent/GB1397073A/en not_active Expired
-
1972
- 1972-05-18 FR FR7217790A patent/FR2138079B1/fr not_active Expired
- 1972-05-18 BE BE783653A patent/BE783653A/xx unknown
- 1972-05-18 ZA ZA723387A patent/ZA723387B/xx unknown
- 1972-05-18 NL NL7206759A patent/NL7206759A/xx unknown
- 1972-05-18 DE DE19722224338 patent/DE2224338A1/de active Pending
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001814A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Serine protease inhibitors |
| US6001813A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Val-pro containing α-keto oxadiazoles as serine protease inhibitors |
| US5801148A (en) * | 1994-11-21 | 1998-09-01 | Cortech, Inc. | Serine protease inhibitors-proline analogs |
| US5807829A (en) * | 1994-11-21 | 1998-09-15 | Cortech, Inc. | Serine protease inhibitor--tripeptoid analogs |
| US5861380A (en) * | 1994-11-21 | 1999-01-19 | Cortech, Inc. | Serine protease inhibitors-keto and di-keto containing ring systems |
| US5869455A (en) * | 1994-11-21 | 1999-02-09 | Cortech, Inc. | Serine protease inhibitors-N-substituted derivatives |
| US5874585A (en) * | 1994-11-21 | 1999-02-23 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
| US5891852A (en) * | 1994-11-21 | 1999-04-06 | Cortech, Inc. | Serine protease inhibitors-cycloheptane derivatives |
| US5998379A (en) * | 1994-11-21 | 1999-12-07 | Cortech Inc. | Serine protease inhibitors-proline analogs |
| US6001811A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Serine protease inhibitors--N-substituted derivatives |
| US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
| US6015791A (en) * | 1994-11-21 | 2000-01-18 | Cortech Inc. | Serine protease inhibitors-cycloheptane derivatives |
| WO1996016080A1 (en) * | 1994-11-21 | 1996-05-30 | Cortech, Inc. | Human neutrophil elastase inhibitors |
| US6037325A (en) * | 1994-11-21 | 2000-03-14 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
| US6100238A (en) * | 1994-11-21 | 2000-08-08 | Cortech Inc. | Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors |
| US6150334A (en) * | 1994-11-21 | 2000-11-21 | Cortech, Inc. | Serine protease inhibitors-tripeptoid analogs |
| US6159938A (en) * | 1994-11-21 | 2000-12-12 | Cortech, Inc. | Serine protease inhibitors comprising α-keto heterocycles |
| US6656911B2 (en) | 1994-11-21 | 2003-12-02 | Cortech, Inc. | Serine protease inhibitors |
| US6608175B2 (en) | 1994-11-21 | 2003-08-19 | Cortech, Inc. | Serine protease inhibitors |
| US6656910B2 (en) | 1997-12-04 | 2003-12-02 | Cortech, Inc. | Serine protease inhibitors |
| US6548638B2 (en) | 1998-06-03 | 2003-04-15 | Cortech, Inc. | Peptoid and nonpeptoid containing α-keto oxadiazoles as serine protease inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2138079B1 (enrdf_load_stackoverflow) | 1975-12-26 |
| DE2224338A1 (de) | 1972-11-30 |
| NL7206759A (enrdf_load_stackoverflow) | 1972-11-21 |
| BE783653A (fr) | 1972-11-20 |
| ZA723387B (en) | 1974-01-30 |
| FR2138079A1 (enrdf_load_stackoverflow) | 1972-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |