GB1389435A - 1,4-benzodiazepine derivatives and their preparation - Google Patents
1,4-benzodiazepine derivatives and their preparationInfo
- Publication number
- GB1389435A GB1389435A GB3412474A GB3412474A GB1389435A GB 1389435 A GB1389435 A GB 1389435A GB 3412474 A GB3412474 A GB 3412474A GB 3412474 A GB3412474 A GB 3412474A GB 1389435 A GB1389435 A GB 1389435A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- preparation
- benzodiazepine derivatives
- benzodiazepine
- nchr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical class N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- -1 2-pyrimidyl Chemical group 0.000 abstract 2
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 1
- BVHCYKZSWOWXPO-UHFFFAOYSA-N 1,3-dihydro-1,4-benzodiazepine-2-thione Chemical compound N1C(=S)CN=CC2=CC=CC=C21 BVHCYKZSWOWXPO-UHFFFAOYSA-N 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Polymers & Plastics (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16909171A | 1971-08-04 | 1971-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1389435A true GB1389435A (en) | 1975-04-03 |
Family
ID=22614230
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3412474A Expired GB1389435A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3288572A Expired GB1389434A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3413874A Expired GB1389437A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3412574A Expired GB1389436A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3288572A Expired GB1389434A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3413874A Expired GB1389437A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3412574A Expired GB1389436A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
Country Status (8)
| Country | Link |
|---|---|
| JP (3) | JPS5714351B1 (enExample) |
| AU (1) | AU461139B2 (enExample) |
| BE (1) | BE787251A (enExample) |
| CH (3) | CH591488A5 (enExample) |
| DE (1) | DE2237592C2 (enExample) |
| FR (1) | FR2150732B1 (enExample) |
| GB (4) | GB1389435A (enExample) |
| ZA (1) | ZA724880B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3917627A (en) * | 1971-08-04 | 1975-11-04 | Upjohn Co | 6-Substituted 4H-imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines and process for their production |
| FR2183716A1 (en) * | 1972-05-05 | 1973-12-21 | Centre Etd Ind Pharma | Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants |
| ZA755418B (en) * | 1974-09-11 | 1977-06-29 | Hoffmann La Roche | Diazepine derivatives |
| US3910946A (en) * | 1974-09-12 | 1975-10-07 | Upjohn Co | 4H-Imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines |
| DE2549686A1 (de) * | 1974-11-06 | 1976-05-13 | Parke Davis & Co | 4-aryl-1,6-dihydro-trimethylimidazoeckige klammer auf 1,2-a eckige klammer zu pyrazolo eckige klammer auf 4,3-f eckige klammer zu eckige klammer auf 1,4 eckige klammer zu diazepin-verbindungen und verfahren zu deren herstellung |
| DE2609486A1 (de) * | 1975-08-07 | 1977-05-12 | Hoffmann La Roche | Imidazo eckige klammer auf 1,5-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu diazepin-verbindungen und verfahren zu ihrer herstellung |
| US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
| WO1994026723A2 (en) * | 1993-05-14 | 1994-11-24 | Genentech, Inc. | ras FARNESYL TRANSFERASE INHIBITORS |
| WO1996023790A1 (de) * | 1995-02-02 | 1996-08-08 | F. Hoffmann-La Roche Ag | Acetylimidazobenzodiazepine |
| EP4299126A3 (en) | 2014-06-26 | 2024-04-03 | The Johns Hopkins University | Peripherally restricted gaba positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system |
| EP3535253A1 (en) | 2016-11-01 | 2019-09-11 | H. Hoffnabb-La Roche Ag | 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of cns related diseases |
| CN113717176B (zh) * | 2021-10-09 | 2022-07-05 | 上海再启生物技术有限公司 | 一种制备瑞马唑仑的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987052A (en) * | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
-
0
- BE BE787251D patent/BE787251A/xx not_active IP Right Cessation
-
1972
- 1972-07-13 GB GB3412474A patent/GB1389435A/en not_active Expired
- 1972-07-13 GB GB3288572A patent/GB1389434A/en not_active Expired
- 1972-07-13 GB GB3413874A patent/GB1389437A/en not_active Expired
- 1972-07-13 GB GB3412574A patent/GB1389436A/en not_active Expired
- 1972-07-14 ZA ZA724880A patent/ZA724880B/xx unknown
- 1972-07-18 AU AU44673/72A patent/AU461139B2/en not_active Expired
- 1972-07-28 CH CH1435675A patent/CH591488A5/xx not_active IP Right Cessation
- 1972-07-28 CH CH1130272A patent/CH574444A5/xx not_active IP Right Cessation
- 1972-07-28 CH CH1435775A patent/CH584206A5/xx not_active IP Right Cessation
- 1972-07-31 DE DE2237592A patent/DE2237592C2/de not_active Expired
- 1972-08-03 FR FR7228090A patent/FR2150732B1/fr not_active Expired
- 1972-08-04 JP JP7775772A patent/JPS5714351B1/ja active Pending
-
1979
- 1979-08-02 JP JP9817279A patent/JPS5547686A/ja active Granted
-
1980
- 1980-06-16 JP JP8030780A patent/JPS5726667A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5734277B2 (enExample) | 1982-07-22 |
| GB1389436A (en) | 1975-04-03 |
| JPS5714351B1 (enExample) | 1982-03-24 |
| GB1389437A (en) | 1975-04-03 |
| DE2237592C2 (de) | 1985-08-14 |
| ZA724880B (en) | 1973-06-27 |
| JPS5732066B2 (enExample) | 1982-07-08 |
| BE787251A (fr) | 1973-02-05 |
| AU461139B2 (en) | 1975-05-15 |
| CH584206A5 (enExample) | 1977-01-31 |
| JPS5547686A (en) | 1980-04-04 |
| AU4467372A (en) | 1974-01-24 |
| DE2237592A1 (de) | 1973-02-15 |
| CH591488A5 (enExample) | 1977-09-30 |
| FR2150732B1 (enExample) | 1976-04-16 |
| FR2150732A1 (enExample) | 1973-04-13 |
| GB1389434A (en) | 1975-04-03 |
| JPS5726667A (en) | 1982-02-12 |
| CH574444A5 (enExample) | 1976-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1374824A (en) | Triazolobenzodiazepines | |
| GB1389435A (en) | 1,4-benzodiazepine derivatives and their preparation | |
| GB1457078A (en) | Pyrazolo pyridine derivatives | |
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| GB1365455A (en) | Imdazobensodiazepines | |
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| GB1350722A (en) | Triazolo benzodiazepines | |
| GB1449426A (en) | Phenoxyalkylamine derivatives and preparation therof | |
| IE34609L (en) | Therapeutic substituted thiazolidinedione | |
| IE34252L (en) | Tricyclic benzodiazepines. | |
| GB1369342A (en) | Benzodiazepine derivatives | |
| GB1360693A (en) | Triazolobenzo-diazepines and the manufacture thereof | |
| GB1491667A (en) | Preparation of 1-((dimethylamino)methyl)-6-aryl-4h-s-triazolo(4,3-a)(1,4)benzodiazepines | |
| GB1323591A (en) | Benzodiazepine derivatives | |
| GB1207475A (en) | Improvements in or relating to the production of heterocyclic compounds having an imidazole ring | |
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| GB1381158A (en) | Benzodiazepines and the manufacture thereof | |
| GB1374529A (en) | Benzodiazepines | |
| GB1226251A (enExample) | ||
| IE33446L (en) | Isothiocyano-diphenylamines | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |