GB1377435A - Triazolobenzodiazepines - Google Patents
TriazolobenzodiazepinesInfo
- Publication number
- GB1377435A GB1377435A GB1691372A GB1691372A GB1377435A GB 1377435 A GB1377435 A GB 1377435A GB 1691372 A GB1691372 A GB 1691372A GB 1691372 A GB1691372 A GB 1691372A GB 1377435 A GB1377435 A GB 1377435A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- oxazirinotriazolobenzodiazepines
- triazolobenzodiazepine
- alkoxy
- oxides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- -1 nitromethyl Chemical group 0.000 abstract 3
- KYTREVLPRJOBEM-UHFFFAOYSA-N triazolo[4,5-i][1,2]benzodiazepine Chemical compound C1=CC2=CC=CN=NC2=C2C1=NN=N2 KYTREVLPRJOBEM-UHFFFAOYSA-N 0.000 abstract 3
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000003674 animal food additive Substances 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000003326 hypnotic agent Substances 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 150000004965 peroxy acids Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14241871A | 1971-05-11 | 1971-05-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1377435A true GB1377435A (en) | 1974-12-18 |
Family
ID=22499766
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1691372A Expired GB1377435A (en) | 1971-05-11 | 1972-04-12 | Triazolobenzodiazepines |
| GB5857273A Expired GB1380880A (en) | 1971-05-11 | 1972-04-12 | Triazolobenzodiazepines |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5857273A Expired GB1380880A (en) | 1971-05-11 | 1972-04-12 | Triazolobenzodiazepines |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US3681343A (cg-RX-API-DMAC10.html) |
| AU (1) | AU472686B2 (cg-RX-API-DMAC10.html) |
| BE (1) | BE783273A (cg-RX-API-DMAC10.html) |
| CH (3) | CH573942A5 (cg-RX-API-DMAC10.html) |
| DE (1) | DE2221790A1 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2137713B1 (cg-RX-API-DMAC10.html) |
| GB (2) | GB1377435A (cg-RX-API-DMAC10.html) |
| NL (1) | NL7206302A (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA722560B (cg-RX-API-DMAC10.html) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2156472A1 (de) | 1970-11-23 | 1972-05-31 | Ciba-Geigy Ag, Basel (Schweiz) | Verfahren zur Herstellung von neuen Diazepinderivaten |
| JPS4932874B1 (cg-RX-API-DMAC10.html) * | 1970-12-11 | 1974-09-03 | ||
| US3946032A (en) * | 1971-04-08 | 1976-03-23 | Ciba-Geigy Corporation | Acetal derivatives of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde |
| CH545302A (de) * | 1971-04-08 | 1974-01-13 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten |
| US4250094A (en) * | 1971-04-28 | 1981-02-10 | The Upjohn Company | 1-(Aminoalkyl) substituted-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
| US4902794A (en) * | 1971-04-28 | 1990-02-20 | The Upjohn Company | Triazolo-benzodiazepines |
| DE2308280A1 (de) * | 1971-11-15 | 1973-09-06 | Ciba Geigy Ag | Verfahren zur herstellung von neuen diazepinderivaten |
| US3886174A (en) * | 1971-11-22 | 1975-05-27 | Upjohn Co | 1-Substituted-6-phenyl-4H-s-triazolo{8 4,3-a{9 {8 1,4{9 benzodiazepines |
| CH567031A5 (cg-RX-API-DMAC10.html) * | 1972-05-18 | 1975-09-30 | Ciba Geigy Ag | |
| US3879406A (en) * | 1972-07-13 | 1975-04-22 | Hoffmann La Roche | Preparation of triazolobenzodiazepines |
| IE38931B1 (en) * | 1973-03-09 | 1978-07-05 | Lipha | Triazolobenzodiazepines |
| IE41197B1 (en) | 1973-05-29 | 1979-11-07 | Squibb & Sons Inc | 4h-s-triazolo (4,3-a)(1,5)benzodiazepin-5-ones |
| US4213982A (en) | 1973-05-29 | 1980-07-22 | E. R. Squibb & Sons, Inc. | Novel 4H-S-triazolo[4,3-A] [1,5]benzodiazepin-5-ones |
| AT338799B (de) | 1974-03-02 | 1977-09-12 | Boehringer Sohn Ingelheim | Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze |
| JPS5747914B2 (cg-RX-API-DMAC10.html) * | 1974-04-12 | 1982-10-13 | ||
| US3910944A (en) * | 1974-11-20 | 1975-10-07 | Upjohn Co | Spiro(cyclopropane-1,4{40 -(4H)-s-triazolo-(4,3-a)(1,4)benzodiazepines) |
| US4044016A (en) * | 1975-01-13 | 1977-08-23 | Hoffmann-La Roche Inc. | Preparation of triazolo benzodiazepines and novel compounds |
| US4018788A (en) * | 1975-06-16 | 1977-04-19 | The Upjohn Company | 6-(O-Halophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine |
| US4226772A (en) * | 1976-03-15 | 1980-10-07 | The Upjohn Company | 1-[(Dialkylamino)methyl]-6-phenyl-4H-s-[4,3,-a][1,4]triazolobenzodiazepine N1 -oxide |
| US4009175A (en) * | 1976-03-15 | 1977-02-22 | The Upjohn Company | 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines |
| US4415583A (en) * | 1980-03-27 | 1983-11-15 | The Upjohn Company | Process for inducing hypnosis |
| US4374842A (en) * | 1980-04-18 | 1983-02-22 | Shionogi & Co., Ltd. | 4,1-Benzoxazepines and compositions |
| US4479959A (en) * | 1981-01-29 | 1984-10-30 | The Upjohn Company | Process for inducing hypnosis |
| US4444781A (en) * | 1981-04-06 | 1984-04-24 | The Upjohn Company | Process for inducing hypnosis |
| CN103154246B (zh) | 2010-05-14 | 2015-11-25 | 达那-法伯癌症研究所 | 用于治疗白血病的组合物和方法 |
| AU2015201727B2 (en) * | 2010-05-14 | 2018-03-08 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating neoplasia, inflammatory disease and other disorders |
| ES2606958T3 (es) | 2010-05-14 | 2017-03-28 | Dana-Farber Cancer Institute, Inc. | Compuestos de tienotriazolodiazepina para tratar una neoplasia |
| CN103180318B (zh) | 2010-05-14 | 2017-05-10 | 达那-法伯癌症研究所 | 雄性避孕组合物以及使用方法 |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| WO2012151512A2 (en) | 2011-05-04 | 2012-11-08 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2012174487A2 (en) | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| WO2013184878A1 (en) | 2012-06-06 | 2013-12-12 | Constellation Pharmaceuticals, Inc. | Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof |
| BR112016001457A2 (pt) | 2013-07-25 | 2017-08-29 | Dana Farber Cancer Inst Inc | Inibidores de fatores de transcrição e usos dos mesmos |
| US11446309B2 (en) | 2013-11-08 | 2022-09-20 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (BET) protein inhibitors |
| MX2016009974A (es) | 2014-01-31 | 2016-10-31 | Dana Farber Cancer Inst Inc | Derivados de diaminopirimidina bencensulfona y sus usos. |
| EP3099693A4 (en) | 2014-01-31 | 2017-08-16 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| WO2015131113A1 (en) | 2014-02-28 | 2015-09-03 | Tensha Therapeutics, Inc. | Treatment of conditions associated with hyperinsulinaemia |
| CN106687463B (zh) | 2014-06-20 | 2019-04-09 | 星座制药公司 | 一种乙酰胺类化合物的晶型 |
| RU2017104897A (ru) | 2014-08-08 | 2018-09-10 | Дана-Фарбер Кэнсер Инститьют, Инк. | Производные диазепана и их применения |
| WO2016022970A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Dihydropteridinone derivatives and uses thereof |
| UA122130C2 (uk) | 2014-10-27 | 2020-09-25 | Тенша Терапеутікс, Інк. | Інгібітори бромодомену |
| CA2986441A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| RU2018112953A (ru) | 2015-09-11 | 2019-10-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Ацетамидтиенотриазолодиазепины и пути их применения |
| US11306105B2 (en) | 2015-09-11 | 2022-04-19 | Dana-Farber Cancer Institute, Inc. | Cyano thienotriazolodiazepines and uses thereof |
| CR20180336A (es) | 2015-11-25 | 2018-08-06 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos |
| CN110769830A (zh) | 2017-05-12 | 2020-02-07 | 马瓦隆治疗有限公司 | 作为ii组代谢型谷氨酸受体的别构调节剂的取代的杂环化合物 |
| TWI878507B (zh) * | 2020-03-31 | 2025-04-01 | 瑞士商赫孚孟拉羅股份公司 | 作為 GABA A γ1 PAM 的新穎苯并二氮呯衍生物 |
| JP2024537773A (ja) | 2021-09-29 | 2024-10-16 | エフ． ホフマン－ラ ロシュ アーゲー | ＧＡＢＡ Ａγ１ ＰＡＭとしての新規ベンゾジアゼピン誘導体 |
| WO2023057415A1 (en) | 2021-10-06 | 2023-04-13 | F. Hoffmann-La Roche Ag | Benzodiazepine derivatives as positive allosteric modulators of the gaba a gamma1 receptor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH540247A (de) * | 1967-04-21 | 1973-09-28 | Ciba Geigy Ag | Verfahren zur Herstellung von heterocyclischen, Asthylendoppelbindungen enthaltenden Verbindungen |
| JPS4837280B1 (cg-RX-API-DMAC10.html) * | 1969-03-08 | 1973-11-09 | ||
| YU34997B (en) * | 1970-03-27 | 1980-06-30 | Hiroyuki Tawada | Process for preparing benzodiazepine derivatives |
-
1971
- 1971-05-11 US US142418A patent/US3681343A/en not_active Expired - Lifetime
-
1972
- 1972-04-12 GB GB1691372A patent/GB1377435A/en not_active Expired
- 1972-04-12 GB GB5857273A patent/GB1380880A/en not_active Expired
- 1972-04-17 ZA ZA722560A patent/ZA722560B/xx unknown
- 1972-04-27 AU AU41640/72A patent/AU472686B2/en not_active Expired
- 1972-05-04 DE DE19722221790 patent/DE2221790A1/de active Pending
- 1972-05-10 CH CH1394475A patent/CH573942A5/xx not_active IP Right Cessation
- 1972-05-10 NL NL7206302A patent/NL7206302A/xx not_active Application Discontinuation
- 1972-05-10 FR FR7216686A patent/FR2137713B1/fr not_active Expired
- 1972-05-10 CH CH1394375A patent/CH572485A5/xx not_active IP Right Cessation
- 1972-05-10 BE BE783273A patent/BE783273A/xx not_active IP Right Cessation
- 1972-05-10 CH CH698872A patent/CH582180A5/xx not_active IP Right Cessation
-
1973
- 1973-07-13 US US37909373 patent/USRE28505E/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7206302A (cg-RX-API-DMAC10.html) | 1972-11-14 |
| FR2137713B1 (cg-RX-API-DMAC10.html) | 1975-12-26 |
| GB1380880A (en) | 1975-01-15 |
| FR2137713A1 (cg-RX-API-DMAC10.html) | 1972-12-29 |
| AU4164072A (en) | 1973-11-01 |
| CH572485A5 (cg-RX-API-DMAC10.html) | 1976-02-13 |
| ZA722560B (en) | 1973-02-28 |
| US3681343A (en) | 1972-08-01 |
| USRE28505E (en) | 1975-08-05 |
| CH582180A5 (cg-RX-API-DMAC10.html) | 1976-11-30 |
| BE783273A (fr) | 1972-11-10 |
| AU472686B2 (en) | 1976-06-03 |
| CH573942A5 (cg-RX-API-DMAC10.html) | 1976-03-31 |
| DE2221790A1 (de) | 1972-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1380880A (en) | Triazolobenzodiazepines | |
| GB1291631A (en) | Triazolobenzodiazepine derivatives | |
| GB1374824A (en) | Triazolobenzodiazepines | |
| ES8700938A1 (es) | Procedimiento para aumentar la adherencia de las bacterias en el estomago e intestinos de seres humanos y animales | |
| GB1389437A (en) | 1,4-benzodiazepine derivatives and their preparation | |
| GB1388439A (en) | 1,4-benzodiazepine-1-acetic acid esters | |
| GB1373300A (en) | Triazolobenzodiazepines and the manufacture thereof | |
| GB1365455A (en) | Imdazobensodiazepines | |
| MY100892A (en) | Veterinary preparations. | |
| IE36623B1 (en) | Benzodiazepine dervatives | |
| GB1237352A (en) | Substituted propylamines | |
| GB1323277A (en) | Triazolobenzodiazepines | |
| GB1126353A (en) | Isoquinolinobenzodiazepine derivatives | |
| GB1348449A (en) | Benzodiazepine derivatives | |
| GB1354627A (en) | Triazolobenzodiazepines | |
| GB1435685A (en) | Hydroxyl-subst | |
| GB1377230A (en) | 4h-s-triazolo -4,3-a- 1,4-benzodiazepines | |
| GB1381158A (en) | Benzodiazepines and the manufacture thereof | |
| GB1225677A (cg-RX-API-DMAC10.html) | ||
| GB1360693A (en) | Triazolobenzo-diazepines and the manufacture thereof | |
| GB1369342A (en) | Benzodiazepine derivatives | |
| GB1383259A (en) | 5-hydroxy-1- -5-substituted phenyl furfurylidene- amino - hydantoins | |
| GB1378617A (en) | Triazolylbenzophenones | |
| GB1352490A (en) | Thiatriazolobenzo diazepines | |
| GB1299801A (en) | Process for preparing benzodiazepine derivatives and salts thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Free format text: IN PAT.BUL.5051,PAGE 3188 FOR 1377438 READ 1377435 |