BE783273A - Nouvelles triazolobenzodiazepines et leur - Google Patents

Nouvelles triazolobenzodiazepines et leur

Info

Publication number
BE783273A
BE783273A BE783273A BE783273A BE783273A BE 783273 A BE783273 A BE 783273A BE 783273 A BE783273 A BE 783273A BE 783273 A BE783273 A BE 783273A BE 783273 A BE783273 A BE 783273A
Authority
BE
Belgium
Prior art keywords
triazolobenzodiazepines
news
news triazolobenzodiazepines
Prior art date
Application number
BE783273A
Other languages
English (en)
French (fr)
Inventor
J B Hester
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BE783273A publication Critical patent/BE783273A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BE783273A 1971-05-11 1972-05-10 Nouvelles triazolobenzodiazepines et leur BE783273A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14241871A 1971-05-11 1971-05-11

Publications (1)

Publication Number Publication Date
BE783273A true BE783273A (fr) 1972-11-10

Family

ID=22499766

Family Applications (1)

Application Number Title Priority Date Filing Date
BE783273A BE783273A (fr) 1971-05-11 1972-05-10 Nouvelles triazolobenzodiazepines et leur

Country Status (9)

Country Link
US (2) US3681343A (xx)
AU (1) AU472686B2 (xx)
BE (1) BE783273A (xx)
CH (3) CH582180A5 (xx)
DE (1) DE2221790A1 (xx)
FR (1) FR2137713B1 (xx)
GB (2) GB1380880A (xx)
NL (1) NL7206302A (xx)
ZA (1) ZA722560B (xx)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4932874B1 (xx) * 1970-12-11 1974-09-03
US3946032A (en) * 1971-04-08 1976-03-23 Ciba-Geigy Corporation Acetal derivatives of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde
CH545302A (de) * 1971-04-08 1974-01-13 Ciba Geigy Ag Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten
US4902794A (en) * 1971-04-28 1990-02-20 The Upjohn Company Triazolo-benzodiazepines
US4250094A (en) * 1971-04-28 1981-02-10 The Upjohn Company 1-(Aminoalkyl) substituted-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
DE2308280A1 (de) * 1971-11-15 1973-09-06 Ciba Geigy Ag Verfahren zur herstellung von neuen diazepinderivaten
US3886174A (en) * 1971-11-22 1975-05-27 Upjohn Co 1-Substituted-6-phenyl-4H-s-triazolo{8 4,3-a{9 {8 1,4{9 benzodiazepines
CH567031A5 (xx) * 1972-05-18 1975-09-30 Ciba Geigy Ag
US3879406A (en) * 1972-07-13 1975-04-22 Hoffmann La Roche Preparation of triazolobenzodiazepines
IE38931B1 (en) * 1973-03-09 1978-07-05 Lipha Triazolobenzodiazepines
IE41197B1 (en) 1973-05-29 1979-11-07 Squibb & Sons Inc 4h-s-triazolo (4,3-a)(1,5)benzodiazepin-5-ones
US4213982A (en) 1973-05-29 1980-07-22 E. R. Squibb & Sons, Inc. Novel 4H-S-triazolo[4,3-A] [1,5]benzodiazepin-5-ones
AT338799B (de) 1974-03-02 1977-09-12 Boehringer Sohn Ingelheim Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze
JPS5747914B2 (xx) * 1974-04-12 1982-10-13
US3910944A (en) * 1974-11-20 1975-10-07 Upjohn Co Spiro(cyclopropane-1,4{40 -(4H)-s-triazolo-(4,3-a)(1,4)benzodiazepines)
US4044016A (en) * 1975-01-13 1977-08-23 Hoffmann-La Roche Inc. Preparation of triazolo benzodiazepines and novel compounds
US4018788A (en) * 1975-06-16 1977-04-19 The Upjohn Company 6-(O-Halophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine
US4009175A (en) * 1976-03-15 1977-02-22 The Upjohn Company 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines
US4226772A (en) * 1976-03-15 1980-10-07 The Upjohn Company 1-[(Dialkylamino)methyl]-6-phenyl-4H-s-[4,3,-a][1,4]triazolobenzodiazepine N1 -oxide
US4415583A (en) * 1980-03-27 1983-11-15 The Upjohn Company Process for inducing hypnosis
US4374842A (en) * 1980-04-18 1983-02-22 Shionogi & Co., Ltd. 4,1-Benzoxazepines and compositions
US4479959A (en) * 1981-01-29 1984-10-30 The Upjohn Company Process for inducing hypnosis
US4444781A (en) * 1981-04-06 1984-04-24 The Upjohn Company Process for inducing hypnosis
JP6022442B2 (ja) 2010-05-14 2016-11-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド 男性用避妊組成物および使用方法
AU2011252808B2 (en) 2010-05-14 2015-05-14 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating neoplasia, inflammatory disease and other disorders
AU2015201727B2 (en) * 2010-05-14 2018-03-08 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating neoplasia, inflammatory disease and other disorders
MX354217B (es) 2010-05-14 2018-02-19 Dana Farber Cancer Inst Inc Composiciones y metodos para el tratamiento de leucemia.
WO2012075456A1 (en) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
WO2012151512A2 (en) 2011-05-04 2012-11-08 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9328117B2 (en) 2011-06-17 2016-05-03 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
BR112016001457A2 (pt) 2013-07-25 2017-08-29 Dana Farber Cancer Inst Inc Inibidores de fatores de transcrição e usos dos mesmos
US11446309B2 (en) 2013-11-08 2022-09-20 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (BET) protein inhibitors
KR20160115953A (ko) 2014-01-31 2016-10-06 다나-파버 캔서 인스티튜트 인크. 디아미노피리미딘 벤젠술폰 유도체 및 그의 용도
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
RU2722179C2 (ru) 2014-02-28 2020-05-28 Тэнша Терапеутикс, Инк. Лечение состояний, ассоциированных с гиперинсулинемией
JP6682522B2 (ja) 2014-06-20 2020-04-15 コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． ２−（（４ｓ）−６−（４−クロロフェニル）−１−メチル−４ｈ−ベンゾ［ｃ］イソオキサゾロ［４，５−ｅ］アゼピン−４−イル）アセトアミドの結晶形態
MX2017001757A (es) 2014-08-08 2017-05-30 Dana Farber Cancer Inst Inc Derivados de dihidropteridinona y sus usos.
MX2017001756A (es) 2014-08-08 2017-05-30 Dana Farber Cancer Inst Inc Derivados de diazepano y sus usos.
EP3212654B1 (en) 2014-10-27 2020-04-08 Tensha Therapeutics, Inc. Bromodomain inhibitors
AU2016276963C1 (en) 2015-06-12 2021-08-05 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
UA123946C2 (uk) 2015-09-11 2021-06-30 Дана-Фарбер Кенсер Інстітьют, Інк. Ацетамідтієнотриазолодіазепіни й шляхи їх застосування
RU2750164C2 (ru) 2015-09-11 2021-06-22 Дана-Фарбер Кэнсер Инститьют, Инк. Цианотиенотриазолодиазепины и пути их применения
WO2017091673A2 (en) 2015-11-25 2017-06-01 Dana-Farber Cancer Institute, Inc. Bivalent bromodomain inhibtors and uses thereof
CA3063288A1 (en) 2017-05-12 2018-11-15 Mavalon Therapeutics Limited Substituted heterocyclic compounds as allosteric modulators of group ii metabotropic glutamate receptors
TW202200585A (zh) 2020-03-31 2022-01-01 瑞士商赫孚孟拉羅股份公司 作為 GABA A γ1 PAM 的新穎苯并二氮呯衍生物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH540247A (de) * 1967-04-21 1973-09-28 Ciba Geigy Ag Verfahren zur Herstellung von heterocyclischen, Asthylendoppelbindungen enthaltenden Verbindungen
JPS4837280B1 (xx) * 1969-03-08 1973-11-09
YU34997B (en) * 1970-03-27 1980-06-30 Hiroyuki Tawada Process for preparing benzodiazepine derivatives

Also Published As

Publication number Publication date
CH582180A5 (xx) 1976-11-30
AU4164072A (en) 1973-11-01
US3681343A (en) 1972-08-01
ZA722560B (en) 1973-02-28
CH572485A5 (xx) 1976-02-13
GB1377435A (en) 1974-12-18
FR2137713B1 (xx) 1975-12-26
USRE28505E (en) 1975-08-05
AU472686B2 (en) 1976-06-03
GB1380880A (en) 1975-01-15
FR2137713A1 (xx) 1972-12-29
NL7206302A (xx) 1972-11-14
DE2221790A1 (de) 1972-11-23
CH573942A5 (xx) 1976-03-31

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: THE UPJOHN CY

Effective date: 19860531