GB1366133A - Fused ring indole derivatives - Google Patents
Fused ring indole derivativesInfo
- Publication number
- GB1366133A GB1366133A GB125071*[A GB125071A GB1366133A GB 1366133 A GB1366133 A GB 1366133A GB 125071 A GB125071 A GB 125071A GB 1366133 A GB1366133 A GB 1366133A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- aryl
- ketones
- prepared
- possibly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Priority Applications (47)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB125071*[A GB1366133A (en) | 1971-01-11 | 1971-01-11 | Fused ring indole derivatives |
CY926A CY926A (en) | 1971-01-11 | 1971-12-14 | Fused ring indole derivatives |
ZA718536A ZA718536B (en) | 1971-01-11 | 1971-12-21 | Heterocyclic compounds |
CA130950A CA924724A (en) | 1971-01-11 | 1971-12-23 | Heterocyclic compounds |
AU37558/72A AU464388B2 (en) | 1971-01-11 | 1972-01-04 | Fused n-heteroindole derivatives |
AT7772A AT312595B (de) | 1971-01-11 | 1972-01-05 | Verfahren zur Herstellung von neuen Indolverivaten und ihren Salzen |
DE19722200584 DE2200584A1 (de) | 1971-01-11 | 1972-01-07 | Heterocyclische Verbindungen,Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen |
PH13164*A PH10257A (en) | 1971-01-11 | 1972-01-07 | 2,3,4,10-tetrahydro and 1,2,3,4,10-hexahydropyrimido(1,2-a)indoles |
ES398678A ES398678A1 (es) | 1971-01-11 | 1972-01-08 | Un procedimiento para preparar un derivado de indol. |
IE14/72A IE35956B1 (en) | 1971-01-11 | 1972-01-08 | Fused ring indole derivatives |
EG12/72A EG10888A (en) | 1971-01-11 | 1972-01-09 | Process for preparation of heterocyclic compound from indofe derivatives |
DK11672A DK150143C (da) | 1971-01-11 | 1972-01-10 | Analogifremgangsmaade til fremstilling af indolderivater |
FI45/72A FI54120C (fi) | 1971-01-11 | 1972-01-10 | Foerfarande foer framstaellning av farmaceutiskt anvaendbara antidepressivt verkande tetrahydropyrimido(1,2-a)indol-tetrahydro-1,3-diazepino(1-2-a)indol- och dihydroimidazo(1,2-a)indolderivat |
FR7200619A FR2121699B1 (da) | 1971-01-11 | 1972-01-10 | |
AR240009A AR192734A1 (es) | 1971-01-11 | 1972-01-10 | Un procedimiento para preparar un derivado de indol |
BE777911A BE777911A (fr) | 1971-01-11 | 1972-01-11 | Nouveaux composes heterocycliques, leur preparation et compositions pharmaceutiques les contenant |
CH36472A CH573938A5 (da) | 1971-01-11 | 1972-01-11 | |
NLAANVRAGE7200415,A NL174251C (nl) | 1971-01-11 | 1972-01-11 | Werkwijze voor het bereiden van farmaceutische preparaten op basis van indoolderivaten, alsmede werkwijze ter bereiding van indoolderivaten. |
JP725481A JPS5531156B2 (da) | 1971-01-11 | 1972-01-11 | |
SE7200278A SE398645B (sv) | 1971-01-11 | 1972-01-11 | Analogiforfarande for framstellning av kondenserade indolforeningar |
KE2777A KE2777A (en) | 1971-01-11 | 1972-10-26 | Fused ring indole derivatives |
IE156872A IE37158B1 (en) | 1971-01-11 | 1972-11-15 | Tetrahydropyrimidines imidazolines and tetrahydro-1,3- diazepines |
CA156,588A CA1010448A (en) | 1971-01-11 | 1972-11-16 | Tetrahydropyrimidine, imidazoline and tetrahydro-1,3-diazepine derivatives |
AU48992/72A AU475629B2 (en) | 1971-01-11 | 1972-11-17 | Tetrahydo-pyrimidines, imidazolines and tetrahydro-1, 3-diazepines |
CA157,326A CA1012150A (en) | 1971-01-11 | 1972-11-23 | Indole derivatives |
PH14115A PH9906A (en) | 1971-01-11 | 1972-11-24 | Tetrahydropyrimidines,imidazolines and tetrahydro-1,3-diazepines |
DE19722257784 DE2257784A1 (de) | 1971-01-11 | 1972-11-24 | Heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in pharmazeutischen zubereitungen |
ES409296A ES409296A1 (es) | 1971-01-11 | 1972-12-05 | Un procedimiento para preparar compuestos heterociclos de- rivados de la perimidina, imidazolina y diacepina. |
AR24549472A AR199650A1 (es) | 1971-01-11 | 1972-12-05 | Procedimiento para preparar derivados de la tetrahidropirimidina |
SE1585672A SE398643B (sv) | 1971-01-11 | 1972-12-05 | Forfarande for framstellning av derivat av imidazolin, tetra hydro-pyrimidin och tetra hydro-1,3-diazepin |
CH125876A CH575398A5 (en) | 1971-01-11 | 1972-12-06 | Derivs of tetrahydrpyrimidines,imidazolin and tetrahydro - -1,3-diazepin - with diuretic anti-inflammatory,cardiovascular,hypogl |
NL7216545A NL7216545A (da) | 1971-01-11 | 1972-12-06 | |
CH125976A CH576450A5 (da) | 1971-01-11 | 1972-12-06 | |
CH1772572A CH575931A5 (da) | 1971-01-11 | 1972-12-06 | |
US00313232A US3850957A (en) | 1971-01-11 | 1972-12-08 | 2,3-dihydroimidazo(1,2-a)indoles |
US361701A US3891644A (en) | 1971-01-11 | 1973-05-18 | 10,10-Disubstituted-2,3,4,10-tetrahydro-and 1,2,3,4,10a-hexahydropyrimidol {8 1,2-a{9 indole derivatives |
AR24906573A AR199405A1 (es) | 1971-01-11 | 1973-07-12 | Procedimiento para preparar derivados de tetrahidropirimidina |
AR24906473A AR201197A1 (es) | 1971-01-11 | 1973-07-12 | Procedimiento para preparar derivados de tetrahidropirimidina |
DE19742417917 DE2417917A1 (de) | 1971-01-11 | 1974-04-11 | Verfahren zur herstellung von indolderivaten mit ankondensiertem ringsystem |
US472759A US3926994A (en) | 1971-01-11 | 1974-05-23 | Heterocyclic compounds |
US05/490,812 US3998842A (en) | 1971-01-11 | 1974-07-22 | Diazepino[1,2-α]indoles |
AR25535974A AR200230A1 (es) | 1971-01-11 | 1974-08-28 | Procedimiento para preparar una tetrahidro-1,3-diazepina |
AR25535874A AR200229A1 (es) | 1971-01-11 | 1974-08-28 | Procedimiento para preparar una imidazolina |
US05/582,038 US3996207A (en) | 1971-01-11 | 1975-05-29 | Derivatives of tetrahydro-1H-1,3-diazepine and hexahydro-1,3-diazocine |
US05/582,043 US3965112A (en) | 1971-01-11 | 1975-05-29 | Imidazoline derivatives |
HK528/77A HK52877A (en) | 1971-01-11 | 1977-10-13 | Fused ring indole derivatives |
MY197848A MY7800048A (en) | 1971-01-11 | 1978-12-31 | Fused ring indole derivatives |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB125071*[A GB1366133A (en) | 1971-01-11 | 1971-01-11 | Fused ring indole derivatives |
GB4095971 | 1971-09-02 | ||
GB5646771 | 1971-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1366133A true GB1366133A (en) | 1974-09-11 |
Family
ID=27253859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB125071*[A Expired GB1366133A (en) | 1971-01-11 | 1971-01-11 | Fused ring indole derivatives |
Country Status (20)
Country | Link |
---|---|
JP (1) | JPS5531156B2 (da) |
AR (1) | AR192734A1 (da) |
AT (1) | AT312595B (da) |
AU (1) | AU464388B2 (da) |
BE (1) | BE777911A (da) |
CA (1) | CA1012150A (da) |
CH (1) | CH573938A5 (da) |
CY (1) | CY926A (da) |
DK (1) | DK150143C (da) |
EG (1) | EG10888A (da) |
ES (2) | ES398678A1 (da) |
FI (1) | FI54120C (da) |
FR (1) | FR2121699B1 (da) |
GB (1) | GB1366133A (da) |
HK (1) | HK52877A (da) |
IE (1) | IE35956B1 (da) |
KE (1) | KE2777A (da) |
MY (1) | MY7800048A (da) |
NL (1) | NL174251C (da) |
SE (1) | SE398645B (da) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4126683A (en) * | 1976-06-11 | 1978-11-21 | John Wyeth & Brother Limited | Fused ring indole derivatives and antidepressant compositions containing them |
US4451465A (en) * | 1981-07-07 | 1984-05-29 | John Wyeth & Brother Ltd. | Anti-obesity agents |
EP0240176A1 (en) * | 1986-03-13 | 1987-10-07 | JOHN WYETH & BROTHER LIMITED | Substituted pyrimidoindoles |
US4783455A (en) * | 1986-06-11 | 1988-11-08 | John Wyeth And Brother Ltd. | Substituted pyrimidoindoles and diazepinoindoles useful as hypoglycaemics |
US4784996A (en) * | 1986-03-13 | 1988-11-15 | John Wyeth & Brother Ltd. | Pyrimidoindoles useful as hypoglycaemics |
WO2010090680A1 (en) * | 2008-12-15 | 2010-08-12 | Wyeth Llc | Substituted oxindole cb2 agonists |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5845741B2 (ja) * | 1977-06-06 | 1983-10-12 | 株式会社日立製作所 | 情報検索装置 |
JPS60204057A (ja) * | 1984-03-28 | 1985-10-15 | Casio Comput Co Ltd | デ−タ記憶機能付小型電子機器 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3888846A (en) * | 1967-03-30 | 1975-06-10 | Hoffmann La Roche | Process for 2(2-(1,3-diazacycloalk-2-enyl))benzophenone derivatives and 1,3-diazacycloalkenyl(2,1-a)isoindole derivatives |
US3586693A (en) * | 1969-07-07 | 1971-06-22 | American Home Prod | Imidazo(1,2-a)indolin-9-ols |
-
1971
- 1971-01-11 GB GB125071*[A patent/GB1366133A/en not_active Expired
- 1971-12-14 CY CY926A patent/CY926A/xx unknown
-
1972
- 1972-01-04 AU AU37558/72A patent/AU464388B2/en not_active Expired
- 1972-01-05 AT AT7772A patent/AT312595B/de not_active IP Right Cessation
- 1972-01-08 ES ES398678A patent/ES398678A1/es not_active Expired
- 1972-01-08 IE IE14/72A patent/IE35956B1/xx unknown
- 1972-01-09 EG EG12/72A patent/EG10888A/xx active
- 1972-01-10 FR FR7200619A patent/FR2121699B1/fr not_active Expired
- 1972-01-10 DK DK11672A patent/DK150143C/da not_active IP Right Cessation
- 1972-01-10 FI FI45/72A patent/FI54120C/fi active
- 1972-01-10 AR AR240009A patent/AR192734A1/es active
- 1972-01-11 NL NLAANVRAGE7200415,A patent/NL174251C/xx not_active IP Right Cessation
- 1972-01-11 SE SE7200278A patent/SE398645B/xx unknown
- 1972-01-11 JP JP725481A patent/JPS5531156B2/ja not_active Expired
- 1972-01-11 CH CH36472A patent/CH573938A5/xx not_active IP Right Cessation
- 1972-01-11 BE BE777911A patent/BE777911A/xx not_active IP Right Cessation
- 1972-10-26 KE KE2777A patent/KE2777A/xx unknown
- 1972-11-23 CA CA157,326A patent/CA1012150A/en not_active Expired
- 1972-12-05 ES ES409296A patent/ES409296A1/es not_active Expired
-
1977
- 1977-10-13 HK HK528/77A patent/HK52877A/xx unknown
-
1978
- 1978-12-31 MY MY197848A patent/MY7800048A/xx unknown
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4126683A (en) * | 1976-06-11 | 1978-11-21 | John Wyeth & Brother Limited | Fused ring indole derivatives and antidepressant compositions containing them |
US4451465A (en) * | 1981-07-07 | 1984-05-29 | John Wyeth & Brother Ltd. | Anti-obesity agents |
EP0240176A1 (en) * | 1986-03-13 | 1987-10-07 | JOHN WYETH & BROTHER LIMITED | Substituted pyrimidoindoles |
US4784996A (en) * | 1986-03-13 | 1988-11-15 | John Wyeth & Brother Ltd. | Pyrimidoindoles useful as hypoglycaemics |
US4803207A (en) * | 1986-03-13 | 1989-02-07 | John Wyeth & Brother Ltd. | Hypoglycemic 2',3',10'-tetrahydro-10'-hydroxy-10'-substituted-spiro[cycloakane-1,3'-pyrimido(1,2-a)indole]deratives |
US4783455A (en) * | 1986-06-11 | 1988-11-08 | John Wyeth And Brother Ltd. | Substituted pyrimidoindoles and diazepinoindoles useful as hypoglycaemics |
WO2010090680A1 (en) * | 2008-12-15 | 2010-08-12 | Wyeth Llc | Substituted oxindole cb2 agonists |
Also Published As
Publication number | Publication date |
---|---|
CA1012150A (en) | 1977-06-14 |
NL174251C (nl) | 1984-05-16 |
CH573938A5 (da) | 1976-03-31 |
SE398645B (sv) | 1978-01-09 |
ES409296A1 (es) | 1976-03-16 |
MY7800048A (en) | 1978-12-31 |
DK150143C (da) | 1987-06-01 |
AU3755872A (en) | 1973-07-05 |
BE777911A (fr) | 1972-07-11 |
DK150143B (da) | 1986-12-15 |
NL7200415A (da) | 1972-07-13 |
KE2777A (en) | 1977-10-21 |
NL174251B (nl) | 1983-12-16 |
EG10888A (en) | 1978-06-30 |
AR192734A1 (es) | 1973-03-14 |
JPS5531156B2 (da) | 1980-08-15 |
IE35956B1 (en) | 1976-07-07 |
AT312595B (de) | 1974-01-10 |
FI54120C (fi) | 1978-10-10 |
FR2121699A1 (da) | 1972-08-25 |
JPS4839500A (da) | 1973-06-09 |
FR2121699B1 (da) | 1975-08-01 |
AU464388B2 (en) | 1975-08-28 |
ES398678A1 (es) | 1975-05-16 |
CY926A (en) | 1977-12-23 |
IE35956L (en) | 1972-07-11 |
HK52877A (en) | 1977-10-20 |
FI54120B (fi) | 1978-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |