GB1362839A - Preparation of 5-fluoropyrimidines and intermediate therefrom - Google Patents
Preparation of 5-fluoropyrimidines and intermediate therefromInfo
- Publication number
- GB1362839A GB1362839A GB4610071A GB4610071A GB1362839A GB 1362839 A GB1362839 A GB 1362839A GB 4610071 A GB4610071 A GB 4610071A GB 4610071 A GB4610071 A GB 4610071A GB 1362839 A GB1362839 A GB 1362839A
- Authority
- GB
- United Kingdom
- Prior art keywords
- spectrum
- uracils
- fluoro
- oct
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000005727 5-fluoropyrimidines Chemical class 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 238000001228 spectrum Methods 0.000 abstract 2
- AWONXBGDFDRWRH-UHFFFAOYSA-N 5-fluoro-6-hydroxy-1,3-diazinane-2,4-dione Chemical compound OC1NC(=O)NC(=O)C1F AWONXBGDFDRWRH-UHFFFAOYSA-N 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- VMUWIFNDNXXSQA-UHFFFAOYSA-N hypofluorite Chemical compound F[O-] VMUWIFNDNXXSQA-UHFFFAOYSA-N 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 238000002329 infrared spectrum Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
- 238000004809 thin layer chromatography Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7823570A | 1970-10-05 | 1970-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1362839A true GB1362839A (en) | 1974-08-07 |
Family
ID=22142782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4610071A Expired GB1362839A (en) | 1970-10-05 | 1971-10-04 | Preparation of 5-fluoropyrimidines and intermediate therefrom |
Country Status (16)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2401619C2 (de) * | 1974-01-14 | 1986-04-03 | Kailash Kumar Prof. Dr. 2359 Lentföhrden Gauri | Fungistatisch wirksame Uracilderivate und Verfahren zu ihrer Herstellung |
| JPS52133994A (en) * | 1976-04-29 | 1977-11-09 | Daikin Ind Ltd | Method of fluorination |
| JPS5640813A (en) * | 1979-09-10 | 1981-04-17 | Minolta Camera Co Ltd | Electric power unit for flash emitting device |
| JPS58140098A (ja) * | 1982-01-27 | 1983-08-19 | Daikin Ind Ltd | ウリジン誘導体の製法およびウリジン誘導体 |
| JPS60190769A (ja) * | 1984-03-09 | 1985-09-28 | Sagami Chem Res Center | ５−フルオロウラシルの製造方法 |
| JPH055677Y2 (enrdf_load_stackoverflow) * | 1985-05-22 | 1993-02-15 |
-
1971
- 1971-10-04 ZA ZA716637A patent/ZA716637B/xx unknown
- 1971-10-04 CH CH1442371A patent/CH567002A5/xx not_active IP Right Cessation
- 1971-10-04 JP JP7720771A patent/JPS5432790B1/ja active Pending
- 1971-10-04 DE DE19712149504 patent/DE2149504A1/de not_active Ceased
- 1971-10-04 SE SE7112537A patent/SE408418B/xx unknown
- 1971-10-04 BE BE773446A patent/BE773446A/xx unknown
- 1971-10-04 CA CA124,296A patent/CA1009657A/en not_active Expired
- 1971-10-04 FR FR7135619A patent/FR2110952A5/fr not_active Expired
- 1971-10-04 NL NL7113583A patent/NL7113583A/xx active Search and Examination
- 1971-10-04 NO NO3634/71A patent/NO135985C/no unknown
- 1971-10-04 GB GB4610071A patent/GB1362839A/en not_active Expired
- 1971-10-04 DK DK481171AA patent/DK128496B/da unknown
- 1971-10-04 AR AR238287A patent/AR199762A1/es active
- 1971-10-05 AU AU34181/71A patent/AU454408B2/en not_active Expired
- 1971-10-06 IL IL37855A patent/IL37855A/xx unknown
-
1978
- 1978-02-16 JP JP1710178A patent/JPS53147082A/ja active Granted
- 1978-02-16 JP JP1710078A patent/JPS53147081A/ja active Pending
- 1978-02-16 JP JP53017099A patent/JPS58421B2/ja not_active Expired
- 1978-03-23 HK HK156/78A patent/HK15678A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5432790B1 (enrdf_load_stackoverflow) | 1979-10-16 |
| JPS58421B2 (ja) | 1983-01-06 |
| JPS53147080A (en) | 1978-12-21 |
| ZA716637B (en) | 1972-12-27 |
| CA1009657A (en) | 1977-05-03 |
| HK15678A (en) | 1978-03-31 |
| CH567002A5 (enrdf_load_stackoverflow) | 1975-09-30 |
| JPS53147081A (en) | 1978-12-21 |
| SE408418B (sv) | 1979-06-11 |
| AU454408B2 (en) | 1974-10-31 |
| BE773446A (fr) | 1972-04-04 |
| JPS5516583B2 (enrdf_load_stackoverflow) | 1980-05-02 |
| AU3418171A (en) | 1973-04-12 |
| NL7113583A (enrdf_load_stackoverflow) | 1972-04-07 |
| AR199762A1 (es) | 1974-09-30 |
| DE2149504A1 (de) | 1972-07-06 |
| FR2110952A5 (enrdf_load_stackoverflow) | 1972-06-02 |
| IL37855A0 (en) | 1971-12-29 |
| NO135985B (enrdf_load_stackoverflow) | 1977-03-28 |
| DK128496B (da) | 1974-05-13 |
| IL37855A (en) | 1974-12-31 |
| JPS53147082A (en) | 1978-12-21 |
| NO135985C (enrdf_load_stackoverflow) | 1977-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 48S | Specification amended (sect. 8/1949) | ||
| SPA | Amended specification published | ||
| PCNP | Patent ceased through non-payment of renewal fee |