GB1356437A - Process for the manufacture of cephalosporanic acid derivatives and the derivatives thus obtainable - Google Patents

Process for the manufacture of cephalosporanic acid derivatives and the derivatives thus obtainable

Info

Publication number
GB1356437A
GB1356437A GB2875271A GB2875271A GB1356437A GB 1356437 A GB1356437 A GB 1356437A GB 2875271 A GB2875271 A GB 2875271A GB 2875271 A GB2875271 A GB 2875271A GB 1356437 A GB1356437 A GB 1356437A
Authority
GB
United Kingdom
Prior art keywords
formula
salt
derivatives
manufacture
solvolysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2875271A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of GB1356437A publication Critical patent/GB1356437A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
GB2875271A 1970-06-18 1971-06-18 Process for the manufacture of cephalosporanic acid derivatives and the derivatives thus obtainable Expired GB1356437A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH923270 1970-06-18

Publications (1)

Publication Number Publication Date
GB1356437A true GB1356437A (en) 1974-06-12

Family

ID=4349775

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2875271A Expired GB1356437A (en) 1970-06-18 1971-06-18 Process for the manufacture of cephalosporanic acid derivatives and the derivatives thus obtainable

Country Status (12)

Country Link
AT (1) AT304762B (ja)
BE (1) BE768653A (ja)
CA (1) CA929517A (ja)
CH (1) CH546794A (ja)
DE (1) DE2128605A1 (ja)
FR (1) FR2100776B1 (ja)
GB (1) GB1356437A (ja)
HU (1) HU163508B (ja)
IE (1) IE35366B1 (ja)
NL (1) NL7108351A (ja)
SE (1) SE379354B (ja)
SU (1) SU414793A3 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0722946A1 (de) * 1995-01-12 1996-07-24 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von 3-Formyl-Cephem-Derivaten
US5856474A (en) * 1994-04-25 1999-01-05 Biochemie Gesellschaft, M.B.H. Cephalosporin synthesis
US6887992B2 (en) 1999-09-30 2005-05-03 Otsuka Kagaku Kabushiki Kaisha 3-cephem derivative crystal

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE412238B (sv) * 1971-05-24 1980-02-25 Ciba Geigy Forfarande for framstellning av 7 beta-amino-cefem-4-karboxylsyraforeningar genom dekarbonylering av en 3-formyl-cefem-4-karboxylsyraforening
CH590873A5 (en) * 1972-06-29 1977-08-31 Ciba Geigy Ag Substd 7-beta-amino-cephamone carboxylic acid derivs - antibiotic inters
CA1109860A (en) * 1972-12-08 1981-09-29 Shinji Terao Process for producing lactol-type cephalosporins
US4122260A (en) * 1977-10-04 1978-10-24 Yeda Research And Development Co., Ltd. Cephalosporin derivatives
AT402929B (de) * 1994-05-25 1997-09-25 Biochemie Gmbh Neue cephalosporinderivate, verfahren zu ihrer herstellung und ihre verwendung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH549053A (de) * 1967-11-03 1974-05-15 Ciba Geigy Ag Verfahren zur herstellung von 7-substituierten 3-desacetylisocephalosporansaeuren.

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856474A (en) * 1994-04-25 1999-01-05 Biochemie Gesellschaft, M.B.H. Cephalosporin synthesis
US6034237A (en) * 1994-04-25 2000-03-07 Biochemie Gesellschaft M.B.H. 3-imino-cephalosporins
US6063917A (en) * 1994-04-25 2000-05-16 Biochemie Gesellschaft M.B.H. Cephalosporin synthesis
US6093813A (en) * 1994-04-25 2000-07-25 Biochemie Gesellschaft M.B.H. Cephalosporin compounds
EP0722946A1 (de) * 1995-01-12 1996-07-24 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von 3-Formyl-Cephem-Derivaten
US5631366A (en) * 1995-01-12 1997-05-20 Hoffmann-La Roche Inc. Process for making 3-formylcephem derivatives
US6887992B2 (en) 1999-09-30 2005-05-03 Otsuka Kagaku Kabushiki Kaisha 3-cephem derivative crystal

Also Published As

Publication number Publication date
IE35366L (en) 1971-12-18
SE379354B (ja) 1975-10-06
IE35366B1 (en) 1976-01-21
FR2100776A1 (ja) 1972-03-24
SU414793A3 (ja) 1974-02-05
DE2128605A1 (de) 1971-12-23
HU163508B (ja) 1973-09-27
CA929517A (en) 1973-07-03
BE768653A (fr) 1971-12-17
CH546794A (de) 1974-03-15
NL7108351A (ja) 1971-12-21
FR2100776B1 (ja) 1974-08-30
AT304762B (de) 1973-01-25

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee