GB1354538A - 6,11-dihydrodibenzo-b,e-thiepine derivatives - Google Patents

6,11-dihydrodibenzo-b,e-thiepine derivatives

Info

Publication number
GB1354538A
GB1354538A GB3285171A GB3285171A GB1354538A GB 1354538 A GB1354538 A GB 1354538A GB 3285171 A GB3285171 A GB 3285171A GB 3285171 A GB3285171 A GB 3285171A GB 1354538 A GB1354538 A GB 1354538A
Authority
GB
United Kingdom
Prior art keywords
compound
july
methyl
metal salt
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3285171A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1073670A external-priority patent/CH529783A/en
Priority claimed from CH1073770A external-priority patent/CH529784A/en
Priority claimed from CH1073570A external-priority patent/CH528538A/en
Priority claimed from CH1073870A external-priority patent/CH529785A/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1354538A publication Critical patent/GB1354538A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/12—[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

1354538 Tropanyloxy - dibenzothiepine derivatives SANDOZ Ltd 13 July 1971 [15 July 1970 (4)] 32851/71 Heading C2C Novel compounds of the general Formula I wherein R is C 1-4 alkyl and n is 1 or 2 or where R is other than methyl, is 0, may be prepared by (a) condensing an R substituted nortropane with a compound II wherein X is an acid radical of a reactive ester, (b) treatment of a compound I wherein n is 0 in neutral or weakly acid solution with an alkali metal salt or alkaline earth metal salt of periodic acid, or with the stiochiometric amount of an organic peracid or with the stiochiometric amount of hydrogen peroxide to obtain I in which n is 1, (c) oxidizing a compound I in which n is 0 or 1 with hydrogen peroxide or an organic peracid to I in which n is 2. The intermediate II (wherein X is chlorine) may be formed by treatment of the compound II wherein X is hydroxyl with hydrogen chloride or thionyl chloride. The intermediate I wherein n is zero and R is methyl may be formed by process (a) above. 6,11 - Dihydro - 11 - hydroxy - dibenzo[b,e]- thiepine - 5 - oxide may be prepared from 6,11 - dihydrodibenzo[b,e]thiepin - 11 - ol by process (b) above. Pharmaceutical compositions of compounds I with the usual excipients show activity in acetylcholine and histamine toxicity tests and against gastric ulcers.
GB3285171A 1970-07-15 1971-07-13 6,11-dihydrodibenzo-b,e-thiepine derivatives Expired GB1354538A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH1073670A CH529783A (en) 1970-07-15 1970-07-15 11-(8-alkyl-3-nortropanyloxy)-6,11-dihydro-dibenzo(b,3) thiepin - derivs - used for treatment of stomach ulcers
CH1073770A CH529784A (en) 1970-07-15 1970-07-15 11-(8-alkyl-3-nortropanyloxy)-6,11-dihydro-dibenzo(b,3) thiepin - derivs - used for treatment of stomach ulcers
CH1073570A CH528538A (en) 1970-07-15 1970-07-15 11-(8-alkyl-3-nortropanyloxy)-6,11-dihydro-dibenzo(b,3) thiepin - derivs - used for treatment of stomach ulcers
CH1073870A CH529785A (en) 1970-07-15 1970-07-15 11-(8-alkyl-3-nortropanyloxy)-6,11-dihydro-dibenzo(b,3) thiepin - derivs - used for treatment of stomach ulcers

Publications (1)

Publication Number Publication Date
GB1354538A true GB1354538A (en) 1974-06-05

Family

ID=27429316

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3285171A Expired GB1354538A (en) 1970-07-15 1971-07-13 6,11-dihydrodibenzo-b,e-thiepine derivatives

Country Status (9)

Country Link
US (1) US3716544A (en)
AU (1) AU3116571A (en)
BE (1) BE769968A (en)
DE (1) DE2134820A1 (en)
FR (1) FR2100908B1 (en)
GB (1) GB1354538A (en)
HU (1) HU163777B (en)
NL (1) NL7109301A (en)
SE (1) SE368955B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558107A (en) * 1968-07-29 1971-01-26 William Thomas Williams Foaming agent mixer and method
CH582699A5 (en) * 1973-03-26 1976-12-15 Sandoz Ag
CA1307790C (en) * 1987-08-04 1992-09-22 Ian Anthony Cliffe Ethers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3234235A (en) * 1962-01-19 1966-02-08 American Home Prod Heterocyclic carbinols
CH476015A (en) * 1965-06-28 1969-07-31 Sandoz Ag Process for the production of new tropane ethers
US3519633A (en) * 1967-08-02 1970-07-07 Mead Johnson & Co Certain substituted 5,11-dihydro-10,10-dioxo - dibenz(c,f)(1,2)thiazepin - 5 - yloxyamines

Also Published As

Publication number Publication date
FR2100908B1 (en) 1975-02-07
DE2134820A1 (en) 1972-01-20
BE769968A (en) 1972-01-13
NL7109301A (en) 1972-01-18
SE368955B (en) 1974-07-29
FR2100908A1 (en) 1972-03-24
HU163777B (en) 1973-10-27
US3716544A (en) 1973-02-13
AU3116571A (en) 1973-01-18

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees