GB1352472A - Derivatives of tryptophan - Google Patents
Derivatives of tryptophanInfo
- Publication number
- GB1352472A GB1352472A GB1191072A GB1191072A GB1352472A GB 1352472 A GB1352472 A GB 1352472A GB 1191072 A GB1191072 A GB 1191072A GB 1191072 A GB1191072 A GB 1191072A GB 1352472 A GB1352472 A GB 1352472A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzyl
- compounds
- group
- substituted
- tryptophan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical class C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title abstract 4
- -1 p-carboxyanilino Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- WVDDGKGOMKODPV-UHFFFAOYSA-N hydroxymethyl benzene Natural products OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 abstract 2
- 125000001302 tertiary amino group Chemical group 0.000 abstract 2
- CSEWAUGPAQPMDC-UHFFFAOYSA-N 2-(4-aminophenyl)acetic acid Chemical compound NC1=CC=C(CC(O)=O)C=C1 CSEWAUGPAQPMDC-UHFFFAOYSA-N 0.000 abstract 1
- GACWAELTDHTMHJ-HNNXBMFYSA-N 4-[[(2s)-2-amino-3-(1h-indol-3-yl)propanoyl]amino]benzoic acid Chemical compound O=C([C@H](CC=1C2=CC=CC=C2NC=1)N)NC1=CC=C(C(O)=O)C=C1 GACWAELTDHTMHJ-HNNXBMFYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001414 amino alcohols Chemical class 0.000 abstract 1
- 229960004050 aminobenzoic acid Drugs 0.000 abstract 1
- 230000001663 anti-spastic effect Effects 0.000 abstract 1
- NZXMUUWGACTPIM-QFIPXVFZSA-N benzyl 4-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]benzoate Chemical compound N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)NC1=CC=C(C(=O)OCC2=CC=CC=C2)C=C1 NZXMUUWGACTPIM-QFIPXVFZSA-N 0.000 abstract 1
- 235000019445 benzyl alcohol Nutrition 0.000 abstract 1
- HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical class ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 210000004877 mucosa Anatomy 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT6865271A IT1055518B (it) | 1971-05-18 | 1971-05-18 | Derivatives del triptofano |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1352472A true GB1352472A (en) | 1974-05-08 |
Family
ID=11310165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1191072A Expired GB1352472A (en) | 1971-05-18 | 1972-03-14 | Derivatives of tryptophan |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5139220B2 (enrdf_load_html_response) |
| DE (1) | DE2224130C3 (enrdf_load_html_response) |
| ES (1) | ES402678A1 (enrdf_load_html_response) |
| FR (1) | FR2138046B1 (enrdf_load_html_response) |
| GB (1) | GB1352472A (enrdf_load_html_response) |
| IT (1) | IT1055518B (enrdf_load_html_response) |
| NL (1) | NL173167C (enrdf_load_html_response) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986003489A1 (en) * | 1984-12-12 | 1986-06-19 | Rotta Research Laboratorium S.P.A. | Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them |
| JPS63502108A (ja) * | 1985-12-06 | 1988-08-18 | キ−・ファ−マシュ−ティカルス・インコ−ポレ−テッド | 経皮デリバリ−システム |
| GB2282807A (en) * | 1993-10-15 | 1995-04-19 | Merck & Co Inc | Tryptophan esters and amides as tachykinin receptor antagonists |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4000297A (en) * | 1971-05-18 | 1976-12-28 | Rotta Research Laboratorium S.P.A. | N-p-chlorobenzoyl tryptophane, salts and compositions thereof |
| FR2499076A1 (fr) * | 1981-02-02 | 1982-08-06 | Panmedica Laboratoires | Nouveaux derives de l'acide ((indol-3 yl)-3 amino-2 propionyloxy)-2 acetique, procedes pour leur preparation et medicaments les contenant |
| US4694017A (en) * | 1983-05-19 | 1987-09-15 | Otsuka Pharmaceutical Co., Ltd. | 2-amido 3(oxindol-3-yl)propionic acids having antiulcer activity |
| EP0336356A3 (en) * | 1988-04-05 | 1991-09-25 | Abbott Laboratories | Derivatives of tryptophan as cck antagonists |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2380479A (en) * | 1941-06-06 | 1945-07-31 | Eric T Stiller | dl-tryptophane and processes for producing the same |
-
1971
- 1971-05-18 IT IT6865271A patent/IT1055518B/it active
-
1972
- 1972-03-14 GB GB1191072A patent/GB1352472A/en not_active Expired
- 1972-05-12 ES ES402678A patent/ES402678A1/es not_active Expired
- 1972-05-17 NL NL7206680A patent/NL173167C/xx not_active IP Right Cessation
- 1972-05-17 FR FR7217675A patent/FR2138046B1/fr not_active Expired
- 1972-05-17 DE DE19722224130 patent/DE2224130C3/de not_active Expired
- 1972-05-17 JP JP4827672A patent/JPS5139220B2/ja not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986003489A1 (en) * | 1984-12-12 | 1986-06-19 | Rotta Research Laboratorium S.P.A. | Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them |
| US4870097A (en) * | 1984-12-12 | 1989-09-26 | Rotta Research Laboratorium S.P.A. | Pharmaceutical use of derivatives of tryptophan |
| JPS63502108A (ja) * | 1985-12-06 | 1988-08-18 | キ−・ファ−マシュ−ティカルス・インコ−ポレ−テッド | 経皮デリバリ−システム |
| GB2282807A (en) * | 1993-10-15 | 1995-04-19 | Merck & Co Inc | Tryptophan esters and amides as tachykinin receptor antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2224130A1 (de) | 1972-11-30 |
| NL173167B (nl) | 1983-07-18 |
| JPS5139220B2 (enrdf_load_html_response) | 1976-10-26 |
| JPS4848462A (enrdf_load_html_response) | 1973-07-09 |
| FR2138046B1 (enrdf_load_html_response) | 1975-06-20 |
| ES402678A1 (es) | 1975-04-01 |
| IT1055518B (it) | 1982-01-11 |
| NL7206680A (enrdf_load_html_response) | 1972-11-21 |
| FR2138046A1 (enrdf_load_html_response) | 1972-12-29 |
| NL173167C (nl) | 1983-12-16 |
| DE2224130B2 (de) | 1979-11-08 |
| DE2224130C3 (de) | 1980-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |