GB1333471A - Imidazoline derivatives and process for preparing the same - Google Patents
Imidazoline derivatives and process for preparing the sameInfo
- Publication number
- GB1333471A GB1333471A GB332771A GB1333471DA GB1333471A GB 1333471 A GB1333471 A GB 1333471A GB 332771 A GB332771 A GB 332771A GB 1333471D A GB1333471D A GB 1333471DA GB 1333471 A GB1333471 A GB 1333471A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- preparing
- same
- imidazoline derivatives
- jan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002462 imidazolines Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- ZGMXTDHHELZGGG-UHFFFAOYSA-N 1-(1-benzofuran-2-ylmethyl)-4,5-dihydroimidazole Chemical class O1C2=C(C=C1CN1C=NCC1)C=CC=C2 ZGMXTDHHELZGGG-UHFFFAOYSA-N 0.000 abstract 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 ester salt Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB332771 | 1971-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1333471A true GB1333471A (en) | 1973-10-10 |
Family
ID=9756227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB332771A Expired GB1333471A (en) | 1971-01-27 | 1971-01-27 | Imidazoline derivatives and process for preparing the same |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US3818035A (https=) |
| JP (1) | JPS4938273B1 (https=) |
| AT (1) | AT311336B (https=) |
| BE (1) | BE777689A (https=) |
| CA (1) | CA962273A (https=) |
| CH (1) | CH535254A (https=) |
| DE (1) | DE2203373C3 (https=) |
| DK (1) | DK138496B (https=) |
| FI (1) | FI55841C (https=) |
| GB (1) | GB1333471A (https=) |
| HU (1) | HU162823B (https=) |
| NL (1) | NL150454B (https=) |
| NO (1) | NO134115C (https=) |
| SE (1) | SE378426B (https=) |
| SU (1) | SU474145A3 (https=) |
| YU (1) | YU34694B (https=) |
| ZA (1) | ZA72286B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496572A (en) * | 1981-08-26 | 1985-01-29 | Pfizer Inc. | Benzo-fused thromboxane synthetase inhibitors |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3927023A (en) * | 1974-05-24 | 1975-12-16 | Warner Lambert Co | Imidazolyl benzofurans |
| DE3049542A1 (de) * | 1980-12-31 | 1982-07-29 | Basf Ag, 6700 Ludwigshafen | Azolylalkyl-2,3-dihydrobenzofurane, diese enthaltende fungizide und verfahren zu ihrer herstellung |
| US4806663A (en) * | 1987-04-06 | 1989-02-21 | The University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzofuran derivatives |
| US4851554A (en) * | 1987-04-06 | 1989-07-25 | University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzofuran derivatives |
| US4831156A (en) * | 1987-09-30 | 1989-05-16 | The University Of Tennessee Research Corp. | 3-substituted 2-alkyl indole derivatives |
| DE69814012T2 (de) * | 1997-12-19 | 2004-04-01 | Eli Lilly And Co., Indianapolis | Hypoglykàmische imidazoline derivate |
| US7777035B2 (en) * | 2005-06-22 | 2010-08-17 | Chemocentryx, Inc. | Azaindazole compounds and methods of use |
| AU2007209381A1 (en) * | 2006-01-27 | 2007-08-02 | F. Hoffmann-La Roche Ag | Use of substituted 2-imidazole of imidazoline derivatives |
| AU2007312390B2 (en) * | 2006-10-19 | 2013-03-28 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
| JP5167265B2 (ja) * | 2006-10-19 | 2013-03-21 | エフ．ホフマン−ラ ロシュ アーゲー | 微量アミン関連受容体に親和性を有するアミノメチル−２−イミダゾール |
| CA2668454A1 (en) * | 2006-11-02 | 2008-05-08 | F. Hoffmann-La Roche Ag | Substituted 2-imidazoles |
| WO2008058867A2 (en) * | 2006-11-16 | 2008-05-22 | F. Hoffmann-La Roche Ag | Substituted 4-imidazoles |
| ES2364701T3 (es) * | 2006-12-13 | 2011-09-12 | F. Hoffmann-La Roche Ag | Nuevos 2-imidazoles como ligandos para receptores asociados a aminas trazas. |
| US20080146523A1 (en) * | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
| EP2114906B1 (en) | 2007-02-02 | 2014-08-06 | F. Hoffmann-La Roche AG | 2-aminooxazolines as taar1 ligands for cns disorders |
| CA2676944C (en) * | 2007-02-15 | 2016-01-19 | F. Hoffmann-La Roche Ag | 2-aminooxazolines as taar1 ligands |
| WO2009003868A2 (en) | 2007-07-02 | 2009-01-08 | F. Hoffmann-La Roche Ag | 2 -imidazolines having a good affinity to the trace amine associated receptors (taars) |
| AU2008270444A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
| CA2694362A1 (en) * | 2007-07-27 | 2009-02-05 | F. Hoffmann-La Roche Ag | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands |
| CA2695071A1 (en) * | 2007-08-02 | 2009-02-05 | F. Hoffmann-La Roche Ag | The use of benzamide derivatives for the treatment of cns disorders |
| AU2008285795A1 (en) * | 2007-08-03 | 2009-02-12 | F. Hoffmann-La Roche Ag | Pyridinecarboxamide and benzamide derivatives as TAAR1 ligands |
| US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
| RU2513086C2 (ru) * | 2008-07-24 | 2014-04-20 | Ф.Хоффманн-Ля Рош Аг | Производные 4,5-дигидро-оксазол-2-ила |
| US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
| US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| WO2017157873A1 (en) | 2016-03-17 | 2017-09-21 | F. Hoffmann-La Roche Ag | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1121054B (de) * | 1960-11-23 | 1962-01-04 | Merck Ag E | Verfahren zur Herstellung eines neuen Imidazolinderivates und dessen Saeureadditionssalzen |
-
1971
- 1971-01-27 GB GB332771A patent/GB1333471A/en not_active Expired
-
1972
- 1972-01-05 BE BE777689A patent/BE777689A/xx not_active IP Right Cessation
- 1972-01-06 CH CH17272A patent/CH535254A/fr not_active IP Right Cessation
- 1972-01-10 US US00216795A patent/US3818035A/en not_active Expired - Lifetime
- 1972-01-17 ZA ZA720286A patent/ZA72286B/xx unknown
- 1972-01-25 DE DE2203373A patent/DE2203373C3/de not_active Expired
- 1972-01-26 YU YU181/72A patent/YU34694B/xx unknown
- 1972-01-26 NO NO192/72A patent/NO134115C/no unknown
- 1972-01-26 HU HULA791A patent/HU162823B/hu not_active IP Right Cessation
- 1972-01-26 DK DK34572AA patent/DK138496B/da unknown
- 1972-01-26 SE SE7200867A patent/SE378426B/xx unknown
- 1972-01-27 CA CA133,337A patent/CA962273A/en not_active Expired
- 1972-01-27 JP JP47010207A patent/JPS4938273B1/ja active Pending
- 1972-01-27 SU SU1742351A patent/SU474145A3/ru active
- 1972-01-27 NL NL727201121A patent/NL150454B/xx not_active IP Right Cessation
- 1972-01-27 AT AT64772A patent/AT311336B/de not_active IP Right Cessation
- 1972-01-27 FI FI219/72A patent/FI55841C/fi active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496572A (en) * | 1981-08-26 | 1985-01-29 | Pfizer Inc. | Benzo-fused thromboxane synthetase inhibitors |
| US4590200A (en) * | 1981-08-26 | 1986-05-20 | Pfizer Inc. | Naphthalene thromboxane synthetase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| DK138496B (da) | 1978-09-18 |
| DE2203373B2 (de) | 1977-08-11 |
| NO134115B (https=) | 1976-05-10 |
| SU474145A3 (ru) | 1975-06-14 |
| CA962273A (en) | 1975-02-04 |
| NO134115C (https=) | 1976-08-18 |
| DE2203373C3 (de) | 1978-04-13 |
| FI55841B (fi) | 1979-06-29 |
| JPS4938273B1 (https=) | 1974-10-16 |
| YU34694B (en) | 1979-12-31 |
| AT311336B (de) | 1973-11-12 |
| SE378426B (https=) | 1975-09-01 |
| DE2203373A1 (de) | 1972-08-17 |
| BE777689A (fr) | 1972-07-05 |
| ZA72286B (en) | 1972-09-27 |
| CH535254A (fr) | 1973-03-31 |
| AU3817772A (en) | 1973-07-26 |
| YU18172A (en) | 1979-07-10 |
| FI55841C (fi) | 1979-10-10 |
| NL150454B (nl) | 1976-08-16 |
| NL7201121A (https=) | 1972-07-31 |
| US3818035A (en) | 1974-06-18 |
| DK138496C (https=) | 1979-02-26 |
| HU162823B (https=) | 1973-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |