GB1331216A - Inhaling device for medicinal powder compositions provided in capsule form - Google Patents

Inhaling device for medicinal powder compositions provided in capsule form

Info

Publication number
GB1331216A
GB1331216A GB2489272A GB2489272A GB1331216A GB 1331216 A GB1331216 A GB 1331216A GB 2489272 A GB2489272 A GB 2489272A GB 2489272 A GB2489272 A GB 2489272A GB 1331216 A GB1331216 A GB 1331216A
Authority
GB
United Kingdom
Prior art keywords
capsule
upper member
piercing
mixing chamber
ducts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2489272A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISF SpA
Original Assignee
ISF SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ISF SpA filed Critical ISF SpA
Publication of GB1331216A publication Critical patent/GB1331216A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
GB2489272A 1971-07-17 1972-05-26 Inhaling device for medicinal powder compositions provided in capsule form Expired GB1331216A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT26971/71A IT941426B (it) 1971-07-17 1971-07-17 Inalatore a camera di turbinio per sostanze medicamentose polveriformi

Publications (1)

Publication Number Publication Date
GB1331216A true GB1331216A (en) 1973-09-26

Family

ID=11220655

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2489272A Expired GB1331216A (en) 1971-07-17 1972-05-26 Inhaling device for medicinal powder compositions provided in capsule form

Country Status (10)

Country Link
US (1) US3807400A (enExample)
AT (1) AT333415B (enExample)
BE (1) BE781102A (enExample)
CA (1) CA999202A (enExample)
CH (1) CH563167A5 (enExample)
ES (1) ES208808Y (enExample)
FR (1) FR2146202B1 (enExample)
GB (1) GB1331216A (enExample)
IT (1) IT941426B (enExample)
NL (1) NL7305363A (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3973566A (en) * 1975-01-13 1976-08-10 Syntex Puerto Rico Inc. Inhalation device
US3991761A (en) * 1974-03-18 1976-11-16 Salvatore Cocozza Inhaler for powdered medicaments
EP0041783A1 (en) * 1980-06-06 1981-12-16 FISONS plc Inhalation device for powdered medicaments
DE3050005A1 (de) * 1979-10-30 1982-03-18 Riker Laboratories Inc Breath actuated devices for administering powdered medicaments
DK154473B (da) * 1973-09-18 1988-11-21 Boehringer Sohn Ingelheim Inhalator til pulverformede substanser
US4860740A (en) * 1980-10-30 1989-08-29 Riker Laboratories, Inc. Powder inhalation device
GB2253200A (en) * 1991-02-01 1992-09-02 Harris Pharma Ltd Inhalation apparatus and fracturable capsule for use therewith
DE4239402A1 (de) * 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
US5476093A (en) * 1992-02-14 1995-12-19 Huhtamaki Oy Device for more effective pulverization of a powdered inhalation medicament
US6575160B1 (en) 1997-08-07 2003-06-10 Art Slutsky Inhalation device

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1404338A (en) * 1972-08-04 1975-08-28 Beecham Group Ltd Device for the inhalation of medicaments
GB1459426A (en) * 1973-02-26 1976-12-22 Allen & Hanburys Ltd Inhalation devices
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
GB1387954A (en) * 1973-05-08 1975-03-19 Miles Lab Insufflator
US4014336A (en) * 1975-01-13 1977-03-29 Syntex Puerto Rico, Inc. Inhalation device
US3938516A (en) * 1975-01-13 1976-02-17 Syntex Puerto Rico, Inc. Inhalation device
US3964483A (en) * 1975-01-13 1976-06-22 Syntex Puerto Rico, Inc. Inhalation device
US3948264A (en) * 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
GB1562732A (en) * 1976-02-10 1980-03-12 Allen & Hanburys Ltd Device for dispensing medicaments
US4095596A (en) * 1976-11-26 1978-06-20 Smithkline Corporation Nasal inhaler
US4155359A (en) * 1977-05-23 1979-05-22 Antoni Zagorski Air filtering mask
DE2960616D1 (en) * 1978-05-03 1981-11-12 Fisons Plc Inhalation device
IT1222509B (it) * 1987-08-17 1990-09-05 Miat Spa Insufflatore per la somministrazione di farmaci sotto forma di polvere predosata in opercoli
SE466684B (sv) * 1989-03-07 1992-03-23 Draco Ab Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator
US6048857A (en) * 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
MY105368A (en) * 1990-03-02 1994-09-30 Glaxo Group Ltd Inhalation device.
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
SK280967B6 (sk) * 1990-03-02 2000-10-09 Glaxo Group Limited Inhalačný prístroj
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
NZ250988A (en) * 1990-06-14 1995-09-26 Rhone Poulenc Rorer Ltd Powder inhaler: swirling chamber with anti-static walls
IT1243344B (it) * 1990-07-16 1994-06-10 Promo Pack Sa Inalatore plurimonodose per medicamenti in polvere
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
DE4208880A1 (de) * 1992-03-19 1993-09-23 Boehringer Ingelheim Kg Separator fuer pulverinhalatoren
USD348928S (en) 1992-09-21 1994-07-19 Schering Corporation Inhaler
AU684754B2 (en) * 1993-03-03 1998-01-08 Glaxo Wellcome Inc. Dry powder inhalator medicament carrier
USD365876S (en) 1993-06-16 1996-01-02 Chawla Brindra P S Medicament inhaler
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
US20040237961A1 (en) * 1995-06-08 2004-12-02 Snow John Medlin Inhalation actuated device for use with metered dose inhalers (MDIs)
US5988163A (en) * 1995-08-02 1999-11-23 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
US6209538B1 (en) * 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5692496A (en) * 1995-08-02 1997-12-02 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5823183A (en) * 1995-08-02 1998-10-20 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
USD395499S (en) 1996-04-08 1998-06-23 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6237591B1 (en) 1998-11-02 2001-05-29 Dura Pharmaceuticals, Inc. Turbine dry powder inhaler
US6202643B1 (en) * 1998-02-23 2001-03-20 Thayer Medical Corporation Collapsible, disposable MDI spacer and method
US6152130A (en) * 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
US6142146A (en) * 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
JP2002524107A (ja) 1998-06-12 2002-08-06 マイクロドース・テクノロジーズ・インコーポレーテッド 医薬品および薬剤の計量およびパッケージングさらには移送
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
AUPQ582100A0 (en) * 2000-02-24 2000-03-16 Irm Technologies Pty Ltd Nasal filter and sampler
AU2001234005B2 (en) * 2000-02-28 2006-01-19 Pharmakodex Limited Improvements in or relating to the delivery of oral drugs
US6948494B1 (en) * 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
US7080644B2 (en) 2000-06-28 2006-07-25 Microdose Technologies, Inc. Packaging and delivery of pharmaceuticals and drugs
US6443152B1 (en) * 2001-01-12 2002-09-03 Becton Dickinson And Company Medicament respiratory delivery device
US6722364B2 (en) * 2001-01-12 2004-04-20 Becton, Dickinson And Company Medicament inhalation delivery devices and methods for using the same
US7284553B2 (en) 2002-12-12 2007-10-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient
DE10258360A1 (de) 2002-12-12 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator mit Kapselkammer zum Aufnehmen einer mit Wirkstoff gefüllten Einwegkapsel
WO2005076872A2 (en) * 2004-02-06 2005-08-25 Microdose Technologies, Inc. A blister pack for use with an inhalation device
CN100589849C (zh) 2004-02-24 2010-02-17 微计量技术有限公司 基于合成射流的药物输送方法和装置
MXPA06009516A (es) 2004-02-24 2007-03-26 Microdose Technologies Inc Inhalador con sensor de flujo direccional.
MX2007005522A (es) * 2004-11-10 2007-07-05 Cipla Ltd Inhalador.
DE102005001332A1 (de) * 2005-01-11 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zweiteilige Kapsel mit Vorverschluss zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
DK1901749T3 (en) 2005-05-18 2016-10-24 Raptor Pharmaceuticals Inc Aerosolized fluoroquinolones AND USES THEREOF
US8524735B2 (en) * 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
DE102005022862A1 (de) * 2005-05-18 2006-12-14 Airsec S.A.S Kapseln für Inhalatoren
DE102006009637A1 (de) 2005-10-28 2007-05-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator mit Mundstück mit mikrobiologischer Schutzfunktion
DE102005054383B4 (de) 2005-11-15 2013-10-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Nadel zum Lochen von Pulverkapseln für die Inhalation
WO2007103152A2 (en) * 2006-03-03 2007-09-13 Stc.Unm Dry powder inhaler with aeroelastic dispersion mechanism
WO2007107160A1 (en) 2006-03-21 2007-09-27 Bang & Olufsen Medicom A/S Inhaler flow channel
EP2357015A3 (en) 2006-04-05 2012-07-25 MicroDose Therapeutx, Inc. Variable dose inhalation device
SG170835A1 (en) * 2006-04-05 2011-05-30 Microdose Therapeutx Inc Variable dose inhalation device
DE102006016901A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Mundstück für einen Inhalator
DE102006016904A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
DE102006016903A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
WO2007144659A1 (en) * 2006-06-16 2007-12-21 Cipla Limited Improved dry powder inhaler
US20080163610A1 (en) * 2007-01-05 2008-07-10 Matthew Thomas Baird Method and system for regenerating exhaust system filtering and catalyst components using variable high engine idle
DK2121204T3 (en) 2007-01-12 2016-01-18 Opex Corp A method and apparatus for sorting of items
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US8415390B2 (en) 2008-05-30 2013-04-09 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US11224704B2 (en) * 2007-07-06 2022-01-18 Manta Devices, Llc Dose delivery device for inhalation
DE102007033860A1 (de) 2007-07-20 2009-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Prüfvorrichtung
EP2020249A1 (de) * 2007-08-01 2009-02-04 Boehringer Ingelheim Pharma GmbH & Co. KG Inhalator
US8439033B2 (en) 2007-10-09 2013-05-14 Microdose Therapeutx, Inc. Inhalation device
DE102007052871A1 (de) 2007-11-02 2009-05-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kapsel zur Aufnahme von pharmazeutischen Wirkstoffformulierungen
HUE027246T2 (en) * 2008-01-24 2016-10-28 Vectura Delivery Devices Ltd inhaler
US8371294B2 (en) * 2008-02-29 2013-02-12 Microdose Therapeutx, Inc. Method and apparatus for driving a transducer of an inhalation device
TR200803525A2 (tr) * 2008-05-16 2009-12-21 Bi̇lgi̇ç Mahmut Toz ilaç soluma cihazı.
US8815838B2 (en) 2008-10-07 2014-08-26 David C. Griffith Aerosol fluoroquinolone formulations for improved pharmacokinetics
CA2739893C (en) * 2008-10-07 2016-10-04 Mpex Pharmaceuticals, Inc. Inhalation of levofloxacin for reducing lung inflammation
DE202008015493U1 (de) 2008-11-21 2009-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Faltschachtel
MY159925A (en) * 2009-05-21 2017-02-15 Microdose Therapeutx Inc Rotary cassette system for dry powder inhaler
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US9180263B2 (en) * 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
EP3569235A1 (en) 2009-09-04 2019-11-20 Horizon Orphan LLC Use of aerosolized levofloxacin for treating cystic fibrosis
CA2779488A1 (en) 2009-11-12 2011-05-19 Stc.Unm Dry powder inhaler with flutter dispersion member
CN105381524A (zh) 2010-01-05 2016-03-09 微剂量治疗技术公司 吸入设备和方法
JP6050758B2 (ja) 2010-12-07 2016-12-21 レスピラ セラピューティクス インコーポレイテッドRespira Therapeutics,Inc. 乾燥粉末吸入器及びその作動方法
JP6021117B2 (ja) 2011-01-31 2016-11-02 ジェノア ファーマシューティカルズ,インク. エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
US20150044288A1 (en) 2013-07-31 2015-02-12 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
ZA201408393B (en) 2013-11-19 2015-11-25 Cipla Ltd Inhaler device
EP4491180A1 (en) 2014-01-10 2025-01-15 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
WO2015128789A1 (en) 2014-02-25 2015-09-03 Lupin Limited Inhaler
EA201691872A1 (ru) 2014-03-19 2017-04-28 Инфинити Фармасьютикалз, Инк. Гетероциклические соединения для применения в лечении pi3k-гамма-опосредованных расстройств
WO2015179369A1 (en) 2014-05-20 2015-11-26 Infinity Pharmaceuticals, Inc. Treatment of pulmonary or respiratory diseases by inhalation administration of pi3 kinase inhibitors
WO2015187471A1 (en) * 2014-06-04 2015-12-10 Merck Sharp & Dohme Corp. Dry powder inhaler with dose depletion evaluation
CA2951966C (en) 2014-07-07 2021-03-16 Microdose Therapeutx, Inc. Inhalation device
JP6615860B2 (ja) 2014-07-23 2019-12-04 マイクロドース セラピューテクス,インコーポレイテッド 乾燥粉末噴霧器
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EP3244952A4 (en) 2015-01-14 2018-11-14 Respira Therapeutics, Inc. Powder dispersion methods and devices
CN108349985A (zh) 2015-09-14 2018-07-31 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
WO2018071427A1 (en) 2016-10-11 2018-04-19 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
KR101992171B1 (ko) * 2017-06-27 2019-06-25 한국유나이티드제약 주식회사 건조분말 흡입기
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2573918A (en) * 1949-11-05 1951-11-06 Vick Chemical Company Device for dispensing medicaments
US3669113A (en) * 1966-03-07 1972-06-13 Fisons Ltd Inhalation device
US3507277A (en) * 1966-09-17 1970-04-21 Fisons Pharmaceuticals Ltd Inhalation device
GB1182779A (en) * 1966-09-17 1970-03-04 Fisons Pharmaceuticals Ltd Inhalation Device
GB1268051A (en) * 1968-06-07 1972-03-22 Fisons Pharmaceuticals Ltd Inhalation device

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154473B (da) * 1973-09-18 1988-11-21 Boehringer Sohn Ingelheim Inhalator til pulverformede substanser
US3991761A (en) * 1974-03-18 1976-11-16 Salvatore Cocozza Inhaler for powdered medicaments
US3973566A (en) * 1975-01-13 1976-08-10 Syntex Puerto Rico Inc. Inhalation device
DE3050005A1 (de) * 1979-10-30 1982-03-18 Riker Laboratories Inc Breath actuated devices for administering powdered medicaments
EP0041783A1 (en) * 1980-06-06 1981-12-16 FISONS plc Inhalation device for powdered medicaments
US4860740A (en) * 1980-10-30 1989-08-29 Riker Laboratories, Inc. Powder inhalation device
GB2253200A (en) * 1991-02-01 1992-09-02 Harris Pharma Ltd Inhalation apparatus and fracturable capsule for use therewith
US5476093A (en) * 1992-02-14 1995-12-19 Huhtamaki Oy Device for more effective pulverization of a powdered inhalation medicament
DE4239402A1 (de) * 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
US5435301A (en) * 1992-11-24 1995-07-25 Bayer Aktiengesellschaft Powder inhaler having dispersing, discharge, and dwell-time chambers, along with an acceleration channel
US6575160B1 (en) 1997-08-07 2003-06-10 Art Slutsky Inhalation device

Also Published As

Publication number Publication date
CA999202A (fr) 1976-11-02
BE781102A (fr) 1972-07-17
ATA346473A (de) 1976-03-15
ES208808Y (es) 1976-07-16
FR2146202B1 (enExample) 1976-01-16
FR2146202A1 (enExample) 1973-03-02
IT941426B (it) 1973-03-01
CH563167A5 (enExample) 1975-06-30
US3807400A (en) 1974-04-30
ES208808U (es) 1976-04-01
AT333415B (de) 1976-11-25
NL7305363A (enExample) 1974-05-07

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
433D Application made for revocation (sect. 33/1949)
434A Offer to surrender (sect. 34/1949)
433 Proceeding terminated by voluntary surrender of the patent (sect. 33/1949)
434C Patent revoked (sect. 34/1949)