GB1317028A - Derivatives of secretin - Google Patents
Derivatives of secretinInfo
- Publication number
- GB1317028A GB1317028A GB2485070A GB2485070A GB1317028A GB 1317028 A GB1317028 A GB 1317028A GB 2485070 A GB2485070 A GB 2485070A GB 2485070 A GB2485070 A GB 2485070A GB 1317028 A GB1317028 A GB 1317028A
- Authority
- GB
- United Kingdom
- Prior art keywords
- gly
- asp
- ser
- secretin
- nhnhcbo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 title abstract 2
- 108010047857 aspartylglycine Proteins 0.000 abstract 4
- 108010028188 glycyl-histidyl-serine Proteins 0.000 abstract 2
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- MDXGYYOJGPFFJL-QMMMGPOBSA-N N(alpha)-t-butoxycarbonyl-L-leucine Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)OC(C)(C)C MDXGYYOJGPFFJL-QMMMGPOBSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 108010050848 glycylleucine Proteins 0.000 abstract 1
- 108010018006 histidylserine Proteins 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 229960002101 secretin Drugs 0.000 abstract 1
- 239000004027 secretin derivative Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/645—Secretins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1317028 Secretin derivatives E R SQUIBB & SONS Inc 22 May 1970 [26 May 1969] 24850/70 Heading C2C Novel peptides I R-secretin in which R is an acyl radical derived from an amino acid, carboxylic acid, carbonic acid or dipeptide, are prepared by conventional methods. BOC - gly - his - ser(Bz) - asp - gly - NHNHCBO, H - his - ser(Bz) - asp - gly - NHNHCBO, BOC- gly - his - ser(Bz) - asp - gly - NHNH 2 , and BOC- leu - gly - his - ser(Bz) - asp - gly - NHNHCBO are isolated as intermediates. In the examples, compounds I where R is H-gly-, H-leu-gly- and propionyl are prepared.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82796269A | 1969-05-26 | 1969-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1317028A true GB1317028A (en) | 1973-05-16 |
Family
ID=25250589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2485070A Expired GB1317028A (en) | 1969-05-26 | 1970-05-22 | Derivatives of secretin |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS4911235B1 (en) |
| CA (1) | CA919657A (en) |
| CH (1) | CH523869A (en) |
| DE (1) | DE2025466A1 (en) |
| FR (1) | FR2051559B1 (en) |
| GB (1) | GB1317028A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0047997A2 (en) * | 1980-09-11 | 1982-03-24 | Eisai Co., Ltd. | Peptide, a process for producing the heptacosapeptide and the use of the heptacosapeptide for producing secretin |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE454514B (en) * | 1985-03-11 | 1988-05-09 | Kabigen Ab | INTESTINAL Mammalian Hormone Precursor AND COMPOSITIONS CONTAINING THIS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3417072A (en) * | 1966-05-18 | 1968-12-17 | Squibb & Sons Inc | Intermediates in the synthesis of secretin |
-
1970
- 1970-05-20 CA CA083166A patent/CA919657A/en not_active Expired
- 1970-05-22 GB GB2485070A patent/GB1317028A/en not_active Expired
- 1970-05-25 DE DE19702025466 patent/DE2025466A1/en active Pending
- 1970-05-25 JP JP45045142A patent/JPS4911235B1/ja active Pending
- 1970-05-26 CH CH778970A patent/CH523869A/en not_active IP Right Cessation
- 1970-05-26 FR FR7019201A patent/FR2051559B1/fr not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0047997A2 (en) * | 1980-09-11 | 1982-03-24 | Eisai Co., Ltd. | Peptide, a process for producing the heptacosapeptide and the use of the heptacosapeptide for producing secretin |
| EP0047997A3 (en) * | 1980-09-11 | 1982-05-19 | Eisai Co., Ltd. | Peptide, a process for producing the heptacosapeptide and the use of the heptacosapeptide for producing secretin |
Also Published As
| Publication number | Publication date |
|---|---|
| CA919657A (en) | 1973-01-23 |
| FR2051559A1 (en) | 1971-04-09 |
| FR2051559B1 (en) | 1975-04-18 |
| CH523869A (en) | 1972-06-15 |
| DE2025466A1 (en) | 1970-12-10 |
| JPS4911235B1 (en) | 1974-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |