GB1304074A - - Google Patents

Info

Publication number
GB1304074A
GB1304074A GB2129570A GB2129570A GB1304074A GB 1304074 A GB1304074 A GB 1304074A GB 2129570 A GB2129570 A GB 2129570A GB 2129570 A GB2129570 A GB 2129570A GB 1304074 A GB1304074 A GB 1304074A
Authority
GB
United Kingdom
Prior art keywords
phe
met
trp
asp
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2129570A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1304074A publication Critical patent/GB1304074A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1304074 Octapeptides E R SQUIBB & SONS Inc 4 May 1970 [27 May 1969] 21295/70 Heading C2C Novel peptides of the following formulµ R - Asp - Tyr(SO 3 H) - Met - Gly - Trp - Met- Asp - Phe - NH 2 ; H - Asp - Tyr(SO 3 H) - Met- Gly - Trp - Met - R<SP>1</SP> - Phe - NH 2 ; R<SP>2</SP> - Tyr(SO 3 H)- Met - Gly - Trp - Met - Asp - Phe - NH 2 ; HAsp - Tyr(SO 3 H) - Met - Gly - Trp - R<SP>3</SP> - Asp- Phe - NH 2 ; H - Asp - Tyr(SO 3 H) - R<SP>3 </SP>- Gly- Trp - Met - Asp - Phe - NH 2 ; H - Asp - Tyr(SO 3 H) - Gly - Trp - R<SP>3</SP> - Asp - Phe - NH 2 ; H - TYr(SO 3 H)- Asp - Met - Gly - Trp - Met - Asp - Phe - NH 2 ; H - Asp - Met - Tyr(SO 3 H) - Gly - Trp - Met- Asp - Phe - NH 2 ; H - Asp - Tyr(SO 3 H) - Met- Gly - D - Trp - Met - Asp - D - Phe - NH 2 ; and their salts in which R is acyl; R<SP>1</SP> is alanyl or glutamyl; R<SP>2</SP> is alanyl, α-aminobutyryl, #- aspartyl, maleyl, or fumaryl and R<SP>3</SP> is leucyl. norleucyl or α-aminobutyryl are prepared by methods conventionally used in peptide synthones. The sulphation is carried out, e.g. with a pyridine-SO 3 complex or H 2 SO 4 . Intermediates isolated are H-phe-NH 2 acetate; BOC - ala - phe - NH 2 ; H - ala - phe - NH 2 .CF 3 - COOH; BOC - met - ala - phe - NH 2 ; H - metala - phe - NH 2 .CF 3 COOH; BOC - trp - metala - phe - NH 2 ; H - trp - met - ala - phe- NH 2 .CF 3 COOH; BOC - gly - trp - met - alaphe - NH 2 ; H - gly - trp - met - ala - phe- NH 2 .CF 3 COOH; BOC - met - gly - trp - metala - phe - NH 2 ; H - met - gly - trp - met - alaphe - NH 2 .CF 3 COOH; BOC - asp - tyr - metgly - trp - met - ala - phe - NH 2 ; BOC - leu - aspphe - NH 2 ; H - asp - phe - NH 2 ; H - leu - aspphe - NH 2 .CF 3 COOH; BOC - trp - leu - aspphe - NH 2 ; H - trp - leu - asp - phe - NH 2 .CF 3 - COOH; BOC - gly - trp - leu - asp - phe - NH 2 ; H - gly - trp - leu - asp - phe - NH 2 .CF 3 COOH; BOC - leu - gly - trp - leu - asp - phe - NH 2 ; H - leu - gly - trp - leu - asp - phe - NH 2 .CF 3 - COOH; BOC - asp - tyr - leu - gly - trp - leuasp - phe - NH2; CBO - glu(Bz) - phe - NH 2 ; H - glu - phe - NH 2 ; BOC - met - glu - phe - NH 2 ; H - met - glu - phe - NH 2 ; BOC - trp - met - gluphe - NH 2 ; H - trp - met - glu - phe - NH 2 .CF 3 - COOH; BOC - gly 1 - trp - met - glu - phe - -NH 2 ; H - gly - trp - met - glu - phe - NH 2 .CF 3 COOH; BOC - met - gly - trp - met - glu - phe - NH 2 ; H-tyr-NHNHCBO; BOC-ala-tyr-NHNHCBO BOC - ala - tyr - NHNH 2 ; BOC - ala - tyr - metgly - trp - met asp - phe - NH2; BOC - abutyr - NHNH 2 ; and BOC - abu - tyr - met - glytrp-met-asp-phe-NH 2 .
GB2129570A 1969-05-27 1970-05-04 Expired GB1304074A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82836869A 1969-05-27 1969-05-27

Publications (1)

Publication Number Publication Date
GB1304074A true GB1304074A (en) 1973-01-24

Family

ID=25251606

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2129570A Expired GB1304074A (en) 1969-05-27 1970-05-04

Country Status (6)

Country Link
BR (1) BR6915336D0 (en)
CA (1) CA919658A (en)
CH (1) CH515893A (en)
DE (1) DE2022623A1 (en)
FR (1) FR2051561B1 (en)
GB (1) GB1304074A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2751026A1 (en) 1976-11-29 1978-06-01 Akad Wissenschaften Ddr PROCESS FOR THE PREPARATION OF PEPTIDES CONTAINING TYROSINE SULFATE

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3066728D1 (en) * 1979-04-30 1984-03-29 Max Planck Gesellschaft Tyrosine derivatives, process for their production and their use in the synthesis of peptides
DK489683A (en) * 1982-10-27 1984-04-28 Amano Pharma Co Ltd PROCEDURE FOR PREPARING PEPTIDES
AU644128B2 (en) * 1989-11-27 1993-12-02 Astra Aktiebolag Hexapeptides with sulphate ester groups

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472832A (en) * 1966-08-09 1969-10-14 Farmaceutici Italia Peptides related to caerulein

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2751026A1 (en) 1976-11-29 1978-06-01 Akad Wissenschaften Ddr PROCESS FOR THE PREPARATION OF PEPTIDES CONTAINING TYROSINE SULFATE

Also Published As

Publication number Publication date
CH515893A (en) 1971-11-30
FR2051561A1 (en) 1971-04-09
DE2022623A1 (en) 1970-12-03
CA919658A (en) 1973-01-23
FR2051561B1 (en) 1974-08-30
BR6915336D0 (en) 1973-03-13

Similar Documents

Publication Publication Date Title
ES2063350T3 (en) NEW PROTEINS WITH AN INHIBITING EFFECT OF TNF AND ITS PRODUCTION.
DE3261304D1 (en) Retro-inverso analogues of c-terminal penta and hexapeptides of substance p.
GB1304074A (en)
GB1281383A (en) Sulphonated peptides and their production
Hill et al. The partial amino acid sequence of human myoglobin
GB1239960A (en) Octapeptide intermediates
AR013618A1 (en) METHOD AND COMPOSITIONS FOR THE DISTRIBUTION AND EXPRESSION OF NUCLEIC ACIDS OF INTERFERON
GB9311454D0 (en) Pharmaceutical compositions
GB1294771A (en) Thyrocalcitonin derivative
Milstein The basic sequences of immunoglobulin κ chains: Sequence studies of bence jones proteins Rad, Fr 4 and B6
GB1158724A (en) Amino Acid Derivatives
GB1526367A (en) Polypeptide
GB1309150A (en) Acthactive peptides and process for their manufacture
DE3751398D1 (en) Substrate peptides.
GB1536878A (en) Octapeptide
GB1477002A (en) Peptides
DK262986A (en) PEPTID MATERIAL WITH THYMUS HUMORAL ACTIVITY
GB1346318A (en) Intermediates for peptide enzyme inhibitors
Hui et al. The use of penicillocarboxypeptidase-S1 in amino acid sequencing
GB1317028A (en) Derivatives of secretin
GB1437477A (en) Synthetic peptides
Liébecq Abbreviated designation of amino acid derivatives and peptides
GB1259017A (en)
GB1301514A (en)
GB1298318A (en) Corticotropin peptides

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee