GB1259017A - - Google Patents

Info

Publication number
GB1259017A
GB1259017A GB1259017DA GB1259017A GB 1259017 A GB1259017 A GB 1259017A GB 1259017D A GB1259017D A GB 1259017DA GB 1259017 A GB1259017 A GB 1259017A
Authority
GB
United Kingdom
Prior art keywords
tri
tbu
cys
ome
asn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH699968A external-priority patent/CH498805A/en
Application filed filed Critical
Publication of GB1259017A publication Critical patent/GB1259017A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1,259,017. Synthesis of cystine-containing peptides. CIBA-GEIGY A.G. 30 April, 1969 [10 May, 1968; 21 Aug., 1968; 16 Nov., 1968], No. 21966/69. Heading C2C. Cystine-containing peptides and derivatives thereof are prepared by treating the corresponding S-tritylated-cysteine-containing peptides with iodine. Peptides claimed per se are Intermediates isolated are H-thr(tBu)-OMe; DPC - Ser(tBu) - thr(tBu) - OMe (DPC=2-(pbiphenylyl) - 2 - propyloxycarbonyl); Z-valleu - OMe; DPC - ser(tBu) - thr(tBu) - NHNH 2 ; H - val - leu - OMe, HCl; TRI - cys(TRI) - valleu - OMe(TRI=trityl); H-cys(TRI) - val - leu- OMe; DPC - ser(tBu) - thr(tBu) - cys(TRI)- valleu - (OMe or OH); H - ser(tBu) - thr(tBu) -cys- (TRI) - val - leu - OH; (H or Z) - asn - leu- OMe; (Z or H) - ser(tBu) - asn - leu - OMe; BOC - cys(TRI) - ser(tBu) - asn - leu - (OMe or NHNH 2 ); BOC - cys(TRI) - ser(tBu) - asn - leuser(tBu) - thr(tBu) - cys(TRI) - val - leu - OH; Z - asn - OtBu; H - asn - OtBu; BOC - cys(TRI)- asn - OtBu; (Z or H) - gly - glu(OtBu) 2 ; (H or TRI) - cys(TRI) - gly - glu(OtBu) 2 ; BOC- val - cys(TRI) - gly - glu(OtBu) 2 ; (H or TRI)- cys(TRI) - pro - leu - gly - NH 2 ; Z - tyr(tBu)- ile - glu - asn - OH; BOC - cys(TRI) - tyr (tBu)- ile - glu - asn - OH; and BOC - cys(TRI)- tyr(tBu) - ile - glu - asn - cys(TRI) - pro-leugly-NH 2 .
GB1259017D 1968-05-10 1969-04-30 Expired GB1259017A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH699968A CH498805A (en) 1968-05-10 1968-05-10 Prepn. of cystine-contg. peptides - used in the synthesis of long-chain peptides
CH1253468 1968-08-21
CH1709868 1968-11-16
US81810969A 1969-04-24 1969-04-24

Publications (1)

Publication Number Publication Date
GB1259017A true GB1259017A (en) 1972-01-05

Family

ID=27429031

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1259017D Expired GB1259017A (en) 1968-05-10 1969-04-30

Country Status (6)

Country Link
BE (1) BE732851A (en)
DE (1) DE1922562C3 (en)
DK (1) DK126990B (en)
FR (1) FR2008194A1 (en)
GB (1) GB1259017A (en)
NL (1) NL165149B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4159981A (en) * 1968-08-23 1979-07-03 Ciba-Geigy Corporation Peptides and process for their manufacture
US4347242A (en) * 1975-11-18 1982-08-31 Ciba-Geigy Corporation Hypocalcaemic peptides and process for their manufacture

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3956260A (en) * 1967-11-09 1976-05-11 Ciba-Geigy Corporation Hypocalcaemic peptides and processes for their manufacture
DE1917939C3 (en) * 1969-04-09 1981-04-09 Hoechst Ag, 6000 Frankfurt Process for the production of cystine-containing peptides
CH517705A (en) * 1969-12-16 1972-01-15 Ciba Geigy Ag Process for the production of cystine-containing peptides
DE3011541C2 (en) * 1980-03-21 1983-05-26 Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt Arrangement for detecting the skidding or sliding of the wheels of rail locomotives without running axles

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4159981A (en) * 1968-08-23 1979-07-03 Ciba-Geigy Corporation Peptides and process for their manufacture
US4347242A (en) * 1975-11-18 1982-08-31 Ciba-Geigy Corporation Hypocalcaemic peptides and process for their manufacture

Also Published As

Publication number Publication date
FR2008194A1 (en) 1970-01-16
DK126990B (en) 1973-09-10
NL6907160A (en) 1969-11-12
NL165149B (en) 1980-10-15
DE1922562A1 (en) 1969-11-20
DE1922562C3 (en) 1980-01-10
BE732851A (en) 1969-11-10
DE1922562B2 (en) 1979-05-31

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee