AU1582495A - Recombinant baculovirus and use thereof in the production of monoclonal antibodies - Google Patents
Recombinant baculovirus and use thereof in the production of monoclonal antibodiesInfo
- Publication number
- AU1582495A AU1582495A AU15824/95A AU1582495A AU1582495A AU 1582495 A AU1582495 A AU 1582495A AU 15824/95 A AU15824/95 A AU 15824/95A AU 1582495 A AU1582495 A AU 1582495A AU 1582495 A AU1582495 A AU 1582495A
- Authority
- AU
- Australia
- Prior art keywords
- production
- promotors
- recombinant baculovirus
- monoclonal antibodies
- baculovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Recombinant baculovirus used as an expression vector in the production of immunoglobulins within an insect cell. The invention is characterized by an expression cassette comprising a sequence coding for at least one portion of an immunoglobin H chain, said sequence being transcriptionally controlled by a first baculovirus promotor, and an expression cassette comprising a sequence coding for at least one portion of an immunoglobin L chain, said sequence being transcriptionally controlled by a second baculovirus promotor. The first and second promotors are two different promotors or derivatives of different promotors, the first and second promotors residing in different loci.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9401015A FR2715664B1 (en) | 1994-01-31 | 1994-01-31 | Recombinant baculovirus and its use for the production of monoclonal antibodies. |
FR9401015 | 1994-01-31 | ||
PCT/FR1995/000110 WO1995020672A1 (en) | 1994-01-31 | 1995-01-31 | Recombinant baculovirus and use thereof in the production of monoclonal antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
AU1582495A true AU1582495A (en) | 1995-08-15 |
Family
ID=9459563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU15824/95A Abandoned AU1582495A (en) | 1994-01-31 | 1995-01-31 | Recombinant baculovirus and use thereof in the production of monoclonal antibodies |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0742833B1 (en) |
JP (1) | JPH09511386A (en) |
AT (1) | ATE263251T1 (en) |
AU (1) | AU1582495A (en) |
CA (1) | CA2182380A1 (en) |
DE (1) | DE69532801T2 (en) |
FR (1) | FR2715664B1 (en) |
WO (1) | WO1995020672A1 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6911204B2 (en) | 2000-08-11 | 2005-06-28 | Favrille, Inc. | Method and composition for altering a B cell mediated pathology |
EP1908769A1 (en) * | 2001-08-27 | 2008-04-09 | Genentech, Inc. | A system for antibody expression and assembly |
MXPA04001566A (en) * | 2001-08-27 | 2004-05-17 | Genentech Inc | A system for antibody expression and assembly. |
EA008247B1 (en) * | 2002-09-27 | 2007-04-27 | Паудерджект Рисерч Лимитед | Nucleic acid constructs for gene expression |
EP1532984A1 (en) | 2003-11-19 | 2005-05-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of anti CD44 antibodies for eradicating stem cells in acute myeloid leukemia |
JP2007519422A (en) | 2004-02-02 | 2007-07-19 | アンブレツクス・インコーポレイテツド | Modified human four helix bundle polypeptides and their use |
MXPA06014684A (en) | 2004-06-18 | 2007-02-12 | Ambrx Inc | Novel antigen-binding polypeptides and their uses. |
AU2005322019B2 (en) | 2004-12-22 | 2010-08-26 | Ambrx, Inc. | Formulations of human growth hormone comprising a non-naturally encoded amino acid |
WO2006069246A2 (en) | 2004-12-22 | 2006-06-29 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
BRPI0519430A2 (en) | 2004-12-22 | 2009-02-10 | Ambrx Inc | modified human growth hormone |
SG161210A1 (en) | 2004-12-22 | 2010-05-27 | Ambrx Inc | Methods for expression and purification of recombinant human growth hormone |
ATE541934T1 (en) | 2004-12-22 | 2012-02-15 | Ambrx Inc | AMINOACYL TRNA SYNTHETASE COMPOSITIONS AND USES THEREOF |
KR20080026135A (en) | 2005-06-03 | 2008-03-24 | 암브룩스, 인코포레이티드 | Improved human interferon molecules and their uses |
FR2891552B1 (en) * | 2005-10-05 | 2012-11-30 | Agronomique Inst Nat Rech | RECOMBINANT BACULOVIRUS EXPRESSING MULTIPLE GENES HETEROLOGISTS. |
EP2339014B1 (en) | 2005-11-16 | 2015-05-27 | Ambrx, Inc. | Methods and compositions comprising non-natural amino acids |
NZ574721A (en) | 2006-09-08 | 2012-02-24 | Ambrx Inc | Hybrid suppressor trna for vertebrate cells |
EP2069396B1 (en) | 2006-09-08 | 2015-10-21 | Ambrx, Inc. | Modified human plasma polypeptide or fc scaffolds and their uses |
US8420792B2 (en) | 2006-09-08 | 2013-04-16 | Ambrx, Inc. | Suppressor tRNA transcription in vertebrate cells |
BRPI0809583B1 (en) | 2007-03-30 | 2022-02-22 | Ambrx, Inc | Modified fgf-21 polypeptide, composition comprising the same, method for producing said fgf-21 polypeptide, and cell comprising a polynucleotide |
CA2685596A1 (en) | 2007-05-02 | 2008-11-13 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
NZ603812A (en) | 2007-11-20 | 2014-06-27 | Ambrx Inc | Modified insulin polypeptides and their uses |
SG188143A1 (en) | 2008-02-08 | 2013-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
NZ591235A (en) | 2008-07-23 | 2012-07-27 | Ambrx Inc | Modified bovine g-csf polypeptides comprising non natural amino acid and their uses treating infections such as mastitis |
PL2342223T3 (en) | 2008-09-26 | 2017-09-29 | Ambrx, Inc. | Modified animal erythropoietin polypeptides and their uses |
TR201802361T4 (en) | 2008-09-26 | 2018-03-21 | Ambrx Inc | Microorganisms and vaccines dependent on unnatural amino acid replication. |
NZ600361A (en) | 2009-12-21 | 2014-06-27 | Ambrx Inc | Modified bovine somatotropin polypeptides and their uses |
CN104017063A (en) | 2009-12-21 | 2014-09-03 | Ambrx公司 | Modified porcine somatotropin polypeptides and their uses |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
MY162837A (en) | 2010-08-17 | 2017-07-31 | Ambrx Inc | Modified relaxin polypeptides and their uses |
AR083006A1 (en) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | FORMULATIONS FOR THE STIMULATING FACTOR OF COLONIES OF GRANULOCITS (G-CSF) BOVINE AND VARIANTS OF THE SAME |
US9139863B2 (en) | 2012-03-16 | 2015-09-22 | Genentech, Inc. | Engineered conformationally-stabilized proteins |
US9791445B2 (en) | 2013-01-28 | 2017-10-17 | Kansas State University Research Foundation | Rift Valley Fever Virus glycoproteins, Gn and Gc, and their use |
UY36370A (en) | 2014-10-24 | 2016-04-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | MODIFIED FGF-21 POLIPEPTIDES AND ITS USES |
ES2963839T3 (en) | 2017-02-08 | 2024-04-02 | Bristol Myers Squibb Co | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2033070A1 (en) * | 1989-05-17 | 1990-11-18 | Lois K. Miller | Baculovirus expression vectors |
US5162222A (en) * | 1989-07-07 | 1992-11-10 | Guarino Linda A | Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses |
US5169784A (en) * | 1990-09-17 | 1992-12-08 | The Texas A & M University System | Baculovirus dual promoter expression vector |
EP1136562A3 (en) * | 1991-11-08 | 2003-06-25 | PHARMACIA & UPJOHN COMPANY | Feline leukemia virus vaccines |
-
1994
- 1994-01-31 FR FR9401015A patent/FR2715664B1/en not_active Expired - Fee Related
-
1995
- 1995-01-31 WO PCT/FR1995/000110 patent/WO1995020672A1/en active IP Right Grant
- 1995-01-31 CA CA002182380A patent/CA2182380A1/en not_active Abandoned
- 1995-01-31 JP JP7519925A patent/JPH09511386A/en active Pending
- 1995-01-31 AT AT95907723T patent/ATE263251T1/en not_active IP Right Cessation
- 1995-01-31 EP EP95907723A patent/EP0742833B1/en not_active Expired - Lifetime
- 1995-01-31 DE DE69532801T patent/DE69532801T2/en not_active Expired - Fee Related
- 1995-01-31 AU AU15824/95A patent/AU1582495A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1995020672A1 (en) | 1995-08-03 |
JPH09511386A (en) | 1997-11-18 |
FR2715664A1 (en) | 1995-08-04 |
EP0742833B1 (en) | 2004-03-31 |
CA2182380A1 (en) | 1995-08-03 |
ATE263251T1 (en) | 2004-04-15 |
DE69532801D1 (en) | 2004-05-06 |
FR2715664B1 (en) | 1996-04-12 |
DE69532801T2 (en) | 2005-03-17 |
EP0742833A1 (en) | 1996-11-20 |
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