GB1346318A - Intermediates for peptide enzyme inhibitors - Google Patents

Intermediates for peptide enzyme inhibitors

Info

Publication number
GB1346318A
GB1346318A GB3566573A GB1346318DA GB1346318A GB 1346318 A GB1346318 A GB 1346318A GB 3566573 A GB3566573 A GB 3566573A GB 1346318D A GB1346318D A GB 1346318DA GB 1346318 A GB1346318 A GB 1346318A
Authority
GB
United Kingdom
Prior art keywords
pro
ile
arg
intermediates
enzyme inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3566573A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB1346318A publication Critical patent/GB1346318A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1346318 Peptidates E R SQUIBB & SONS Inc 19 April 1971 [18 March 1970 6 Aug 1970] 35665/73 Divided out of 1346317 Heading C2C The novel peptides (R) n -G-ile-pro-pro-Y (R)n-pro-G-ile-pro-pro-Y (R) n -F-pro-G-ile-pro-pro-Y (R) n -pro-F-pro-G-ile-pro-pro-Y (R) n -arg-pro-F-pro-G-ile-pro-pro-Y (R) n -pro-arg-pro-F-pro-G-ile-pro-pro-Y (R) n -trp-pro-arg-pro-F-pro-G-ile-pro-pro-Y and (R) n -pyroglu-trp-pro-arg-pro-F-pro-Y in which R is an N-terminal protecting group, n is 0 or 1, F is threanyl or glycyl, G is glutamyl or glutaminyl and Y is OH or a carboxyl protecting group are prepared by conventional solid phase methods used in peptide syntheses.
GB3566573A 1970-03-18 1971-04-19 Intermediates for peptide enzyme inhibitors Expired GB1346318A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2086070A 1970-03-18 1970-03-18
US6179470A 1970-08-06 1970-08-06

Publications (1)

Publication Number Publication Date
GB1346318A true GB1346318A (en) 1974-02-06

Family

ID=26693975

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2260371A Expired GB1346317A (en) 1970-03-18 1971-04-19 Peptide enzyme inhibitor
GB3566573A Expired GB1346318A (en) 1970-03-18 1971-04-19 Intermediates for peptide enzyme inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB2260371A Expired GB1346317A (en) 1970-03-18 1971-04-19 Peptide enzyme inhibitor

Country Status (6)

Country Link
JP (3) JPS5725539B1 (en)
CA (1) CA946836A (en)
CH (1) CH536817A (en)
DE (1) DE2108043C3 (en)
FR (1) FR2085719B1 (en)
GB (2) GB1346317A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
JPS59192608A (en) * 1983-04-15 1984-11-01 Riiman Kk Method of mounting wheel cover of automobile

Also Published As

Publication number Publication date
JPS55147249A (en) 1980-11-17
DE2108043C3 (en) 1980-08-21
CA946836A (en) 1974-05-07
JPS5725539B1 (en) 1982-05-29
JPS55143947A (en) 1980-11-10
DE2108043B2 (en) 1979-10-11
CH536817A (en) 1973-05-15
GB1346317A (en) 1974-02-06
FR2085719A1 (en) 1971-12-31
DE2108043A1 (en) 1971-09-30
FR2085719B1 (en) 1976-04-16
JPS5727102B2 (en) 1982-06-08
JPS5727101B2 (en) 1982-06-08

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee