FR2268792A1 - Peptides enzymatic synthesis - by reacting peptide free acids with amino acids or peptides in the presence of pepsin - Google Patents
Peptides enzymatic synthesis - by reacting peptide free acids with amino acids or peptides in the presence of pepsinInfo
- Publication number
- FR2268792A1 FR2268792A1 FR7512497A FR7512497A FR2268792A1 FR 2268792 A1 FR2268792 A1 FR 2268792A1 FR 7512497 A FR7512497 A FR 7512497A FR 7512497 A FR7512497 A FR 7512497A FR 2268792 A1 FR2268792 A1 FR 2268792A1
- Authority
- FR
- France
- Prior art keywords
- peptides
- leu
- phe
- met
- glu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Peptides fo the formula X-A-B-C-Y (I) (where A is Ala, Gln, Asn, omega-Boc-Lys, Leu, Gly, Glu, Glu or Pro, or is a gp. A1-A2 in which A1 is a hydrophilic amino acid residue and A2 si Val, Met, Leu or Glu; B is Phe, Tyr, Leu, Met, Glu, Asp, Gln, Asn or Trp; C is Phe, Leu, lleu, Tyr, Cys- SBzl, Ser-OBzl, Trp or Met; X is an alpha-aminoacid protecting gp. or an amino acid or peptide residue carrying a protecting gp. on its N-terminal; and Y is a carboxyl-protecting gp. or an amino acid or peptide residue carrying a protecting gp. on its C-terminal) (e.g. alpha, omega-Boc-Lys-Phe-Gly-Leu- Met-NH2) are prepd. by reacting peptides of the formula X-A-B-OH (II) (e.g. alpha,omega-Boc-Lys-Phe-OH) with an amino acid or peptide of the formula H-C-Y (III) (e.g. HCL, H-Phe- Gly-Leu-Met-NH2) in the presence of the enzyme pepsin. High yields are obtd.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4626174A JPS5443076B2 (en) | 1974-04-24 | 1974-04-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2268792A1 true FR2268792A1 (en) | 1975-11-21 |
FR2268792B1 FR2268792B1 (en) | 1980-12-12 |
Family
ID=12742249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7512497A Granted FR2268792A1 (en) | 1974-04-24 | 1975-04-22 | Peptides enzymatic synthesis - by reacting peptide free acids with amino acids or peptides in the presence of pepsin |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS5443076B2 (en) |
CA (1) | CA1046441A (en) |
DE (1) | DE2518256C3 (en) |
FR (1) | FR2268792A1 (en) |
NL (1) | NL173183C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2569111A1 (en) * | 1984-08-16 | 1986-02-21 | Rhone Poulenc Sante | NEW DRUGS CONTAINING TRIPEPTIDES |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6027519B2 (en) * | 1977-11-02 | 1985-06-29 | 塩野義製薬株式会社 | New synthesis method for peptide derivatives |
US4497801A (en) * | 1982-09-17 | 1985-02-05 | Fujisawa Pharmaceutical Co., Ltd. | New peptides, process for preparation thereof and use thereof |
DK15888D0 (en) * | 1988-01-14 | 1988-01-14 | Carlsberg Biotechnology Ltd | ENZYMATIC PROCEDURE FOR PREPARING IMMUNO MODULATING PENTAPEPTIDES AND INTERMEDIATES FOR USING THE PROCEDURE |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS496660A (en) * | 1972-05-09 | 1974-01-21 |
-
1974
- 1974-04-24 JP JP4626174A patent/JPS5443076B2/ja not_active Expired
-
1975
- 1975-04-10 NL NLAANVRAGE7504254,A patent/NL173183C/en active
- 1975-04-22 FR FR7512497A patent/FR2268792A1/en active Granted
- 1975-04-24 DE DE2518256A patent/DE2518256C3/en not_active Expired
- 1975-04-29 CA CA225,715A patent/CA1046441A/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2569111A1 (en) * | 1984-08-16 | 1986-02-21 | Rhone Poulenc Sante | NEW DRUGS CONTAINING TRIPEPTIDES |
EP0174245A1 (en) * | 1984-08-16 | 1986-03-12 | Rhone-Poulenc Sante | Medicaments containing tripeptides |
Also Published As
Publication number | Publication date |
---|---|
CA1046441A (en) | 1979-01-16 |
NL173183C (en) | 1983-12-16 |
NL7504254A (en) | 1975-10-28 |
FR2268792B1 (en) | 1980-12-12 |
JPS50140686A (en) | 1975-11-11 |
DE2518256A1 (en) | 1975-11-06 |
DE2518256B2 (en) | 1980-03-13 |
DE2518256C3 (en) | 1980-11-06 |
JPS5443076B2 (en) | 1979-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |