FR2268792A1 - Peptides enzymatic synthesis - by reacting peptide free acids with amino acids or peptides in the presence of pepsin - Google Patents

Peptides enzymatic synthesis - by reacting peptide free acids with amino acids or peptides in the presence of pepsin

Info

Publication number
FR2268792A1
FR2268792A1 FR7512497A FR7512497A FR2268792A1 FR 2268792 A1 FR2268792 A1 FR 2268792A1 FR 7512497 A FR7512497 A FR 7512497A FR 7512497 A FR7512497 A FR 7512497A FR 2268792 A1 FR2268792 A1 FR 2268792A1
Authority
FR
France
Prior art keywords
peptides
leu
phe
met
glu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7512497A
Other languages
French (fr)
Other versions
FR2268792B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Publication of FR2268792A1 publication Critical patent/FR2268792A1/en
Application granted granted Critical
Publication of FR2268792B1 publication Critical patent/FR2268792B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Peptides fo the formula X-A-B-C-Y (I) (where A is Ala, Gln, Asn, omega-Boc-Lys, Leu, Gly, Glu, Glu or Pro, or is a gp. A1-A2 in which A1 is a hydrophilic amino acid residue and A2 si Val, Met, Leu or Glu; B is Phe, Tyr, Leu, Met, Glu, Asp, Gln, Asn or Trp; C is Phe, Leu, lleu, Tyr, Cys- SBzl, Ser-OBzl, Trp or Met; X is an alpha-aminoacid protecting gp. or an amino acid or peptide residue carrying a protecting gp. on its N-terminal; and Y is a carboxyl-protecting gp. or an amino acid or peptide residue carrying a protecting gp. on its C-terminal) (e.g. alpha, omega-Boc-Lys-Phe-Gly-Leu- Met-NH2) are prepd. by reacting peptides of the formula X-A-B-OH (II) (e.g. alpha,omega-Boc-Lys-Phe-OH) with an amino acid or peptide of the formula H-C-Y (III) (e.g. HCL, H-Phe- Gly-Leu-Met-NH2) in the presence of the enzyme pepsin. High yields are obtd.
FR7512497A 1974-04-24 1975-04-22 Peptides enzymatic synthesis - by reacting peptide free acids with amino acids or peptides in the presence of pepsin Granted FR2268792A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4626174A JPS5443076B2 (en) 1974-04-24 1974-04-24

Publications (2)

Publication Number Publication Date
FR2268792A1 true FR2268792A1 (en) 1975-11-21
FR2268792B1 FR2268792B1 (en) 1980-12-12

Family

ID=12742249

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7512497A Granted FR2268792A1 (en) 1974-04-24 1975-04-22 Peptides enzymatic synthesis - by reacting peptide free acids with amino acids or peptides in the presence of pepsin

Country Status (5)

Country Link
JP (1) JPS5443076B2 (en)
CA (1) CA1046441A (en)
DE (1) DE2518256C3 (en)
FR (1) FR2268792A1 (en)
NL (1) NL173183C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2569111A1 (en) * 1984-08-16 1986-02-21 Rhone Poulenc Sante NEW DRUGS CONTAINING TRIPEPTIDES

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6027519B2 (en) * 1977-11-02 1985-06-29 塩野義製薬株式会社 New synthesis method for peptide derivatives
US4497801A (en) * 1982-09-17 1985-02-05 Fujisawa Pharmaceutical Co., Ltd. New peptides, process for preparation thereof and use thereof
DK15888D0 (en) * 1988-01-14 1988-01-14 Carlsberg Biotechnology Ltd ENZYMATIC PROCEDURE FOR PREPARING IMMUNO MODULATING PENTAPEPTIDES AND INTERMEDIATES FOR USING THE PROCEDURE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS496660A (en) * 1972-05-09 1974-01-21

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2569111A1 (en) * 1984-08-16 1986-02-21 Rhone Poulenc Sante NEW DRUGS CONTAINING TRIPEPTIDES
EP0174245A1 (en) * 1984-08-16 1986-03-12 Rhone-Poulenc Sante Medicaments containing tripeptides

Also Published As

Publication number Publication date
NL173183C (en) 1983-12-16
DE2518256C3 (en) 1980-11-06
JPS50140686A (en) 1975-11-11
DE2518256B2 (en) 1980-03-13
NL7504254A (en) 1975-10-28
FR2268792B1 (en) 1980-12-12
JPS5443076B2 (en) 1979-12-18
CA1046441A (en) 1979-01-16
DE2518256A1 (en) 1975-11-06

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Legal Events

Date Code Title Description
ST Notification of lapse