IE35077B1 - Polypeptides and their derivatives - Google Patents

Polypeptides and their derivatives

Info

Publication number
IE35077B1
IE35077B1 IE709/70A IE70970A IE35077B1 IE 35077 B1 IE35077 B1 IE 35077B1 IE 709/70 A IE709/70 A IE 709/70A IE 70970 A IE70970 A IE 70970A IE 35077 B1 IE35077 B1 IE 35077B1
Authority
IE
Ireland
Prior art keywords
thr
leu
ser
boc
gly
Prior art date
Application number
IE709/70A
Other versions
IE35077L (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH995769A external-priority patent/CH515216A/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to IE1172/73A priority Critical patent/IE35078B1/en
Publication of IE35077L publication Critical patent/IE35077L/en
Publication of IE35077B1 publication Critical patent/IE35077B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1314051 Polypeptides SANDOZ Ltd 22 May 1970 [3 June 1969 20 June 1969 (4) 23 June 1969 (3) 26 June 1969 30 June 1969 9 Sept 1969] 24779/70 Heading C2C Novel compounds I: S - CH 2 - CHX - CO - ser - asn - leu - ser - thr - cys - val - leu - gly - lys - leu - ser - gln - glu - leu - hislys - leu - gln - thr - tyr - pro - arg - thr - asnthr-gly-ser-gly-thr-Y wherein X is H, NH 2 , RCONH or R<SP>1</SP>OCONH; R is alkyl or optionally substituted aryl or aralkyl; R<SP>1</SP> is alkyl, alkenyl or optionally substituted aryl or aralkyl; and Y is -pro-NH 2 or -pro-val-NH 2 ; wherein the terminal peptide unit -S-CH 2 -CHX-CO- has the L-configuration where X is NH 2 , RCONH or R<SP>1</SP>OCONH; and wherein ser may be exchanged for thr or ala; asn for asp, gln or glu; thr for ser or ala; lys for lys(BOC), orn; asn or asp; glu for glu(OtBn), gln, asn or asp; leu for tyr; tyr for phe and arg for orn or lys, provided that when sequence is asin I, and Y is -pro-NH 2 , X is other than NH 2 , are prepared by normal methods of peptide synthesis. Intermediates isolated are Z- or H-thr-pro- NH 2 .HCl; Z-ser-gly-(OEt or NHNH 2 ); Z- or H - ser - gly - thr - pro - NH 2 ; Z - asn - thr - gly- OEt; Z - thr - asn - thr - gly - OEt; BOC- arg(NO 2 ) -thr - asn - thr - gly - (OEt or NHNH 2 ); (BOC or H) - arg - thr - asn - thr - gly - ser - glythr - pro - NH 2 ; (Z- or H-) thr - tyr - pro - (OH or OMe); Z-leu-gln-OMe; H-gln-OMe.HCl; Z- lys(BOC) - leu - gln - OMe: Z - his - lys(BOC)- leu - gln - (OMe or NHNH 2 ); Z - his - lys(BOC)- leu - gln - thr - tyr - pro - OH; Z - gln - thr - tyrpro - OH; Z - lys(BOC) - tyr(OMe); Z - hislys(BOC) - tyr - NHNH 2 ; Z - his - lys(BOC)- tyr - gln - thr - tyr - pro - OH; (Z or H) - hislys(BOC) - leu - gln - thr - tyr - pro - arg - thrasn - thr - gly - ser - gly - thr - pro - NH 2 ; H- his - lys(BOC) - tyr - gln - thr - tyr - pro - argthr - asn - thr - gly - ser - gly - thr - pro - NH 2 ; (H or Z) - glu(OtBn) - leu - OMe; (Z or H) - glnglu(OtBu) - leu - OMe; Z - lys(BOC) - leu - ser- OMe; trityl - gly - lys(BOC) - leu - ser - NHNH 2 ; trityl - gly - lys(BOC) - leu - ser - gln - glu(OtBn)- leu - (NHNH 2 or OMe); H - gly - lys(BOC) - leuser - gln - glu(OtBn) - leu - his - lys(BOC) - leugln - thr - tyr - pro - arg - thr - asn - thr - gly- ser - gly - thr - pro - NH 2 ; (H or Z) - gln - leu- OMe; (H or Z) - glu - gln - leu - OMe; tritylgly - lys(BOC) - leu - ser - gin - gln - leu- NHNH 2 ; H - gly - lys(BOC) - leu - ser - glngln - leu - his - lys(BOC) - leu - gln - thr - tyrpro - arg - thr - asn - thr - gly - ser - gly - thrpro - NH 2 ; H - gly - lys(BOC) - leu - ser - glnglu(OtBu) - leu - his - lys(BOC) - tyr - glu - thrtyr - pro - arg - thr - asn - thr - gly - ser - gly - thrpro - NH 2 ; H - gly - lys(BOC) - leu - ser - glngln - leu - his - lys(BOC) - tyr - gin - thr - tyrpro - arg - thr - asn - thr - gly - ser - gly - thrpro - NH 2 ; (H or Z) - cys(Bz) - val - leu - OMe; (H or Z) - thr - cys(Bz) - val - leu - OMe; H - thrcys(Bz) - val - leu - OH; (BOC or H) - asn - leuser - OMe; (BOC or H) - ser - asn - leu - ser- OMe; BOC - cys(Bz) - ser - asn - leu - ser- (NHNH 2 or OMe); BOC - cys - ser - asn - leuser - thr - cys - val - leu - OH; BOC - cys(Bz)- ser - asnleu - ser - thr - cys(Bz) - val - leu - OH; BOC - cys - ser - asn - leu-ser-thr-cys-val-leu- OH; pivaloyl - cys - ser - asn - leu - ser - thr - cysval-leu-OH; pivalic acid p-nitrophenyl ester; ethoxycarbonyl - cys - ser - arn - leu - ser - thr - cys - val-leu-OH; carbonic acid p-nitrophenyl ethyl ester; benzylmercaptopropionyl-ser-asn-leu-ser- # NHNH 2 ; and S-CH 2 CH 2 CO-ser - asn - leuser-thr-cys-val-leu-NHNH 2 . Pharmaceutical compositions comprise a compound I together with a suitable carrier and/or diluent and lower the calcium content in the blood. [GB1314051A]
IE709/70A 1969-06-03 1970-06-02 Polypeptides and their derivatives IE35077B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE1172/73A IE35078B1 (en) 1969-06-03 1970-06-02 Peptides

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
CH840569 1969-06-03
CH946169 1969-06-20
CH945169 1969-06-20
CH945269 1969-06-20
CH945369 1969-06-20
CH955969 1969-06-23
CH956069 1969-06-23
CH956169 1969-06-23
CH979269 1969-06-26
CH995769A CH515216A (en) 1969-06-30 1969-06-30 Synthetic polypeptides - salmon calcitonin derivs. with pharmacodynamic properties
CH1361269 1969-09-09

Publications (2)

Publication Number Publication Date
IE35077L IE35077L (en) 1970-12-03
IE35077B1 true IE35077B1 (en) 1975-11-12

Family

ID=27581430

Family Applications (1)

Application Number Title Priority Date Filing Date
IE709/70A IE35077B1 (en) 1969-06-03 1970-06-02 Polypeptides and their derivatives

Country Status (9)

Country Link
JP (1) JPS5429513B1 (en)
CA (1) CA967950A (en)
DK (1) DK144563C (en)
FI (1) FI54800C (en)
GB (1) GB1314051A (en)
HK (1) HK52476A (en)
IE (1) IE35077B1 (en)
IL (1) IL34630A (en)
NO (1) NO137087C (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4663309A (en) * 1983-06-29 1987-05-05 University Patents, Inc. Novel peptide hormones with calcitonin-like activity

Also Published As

Publication number Publication date
HK52476A (en) 1976-08-27
NO137087C (en) 1977-12-28
IL34630A (en) 1973-10-25
IE35077L (en) 1970-12-03
JPS5429513B1 (en) 1979-09-25
CA967950A (en) 1975-05-20
DK144563C (en) 1982-09-20
IL34630A0 (en) 1970-08-19
NO137087B (en) 1977-09-19
GB1314051A (en) 1973-04-18
FI54800C (en) 1979-03-12
DK144563B (en) 1982-03-29
FI54800B (en) 1978-11-30

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