GB1339101A - Production of phenylalanine derivatives - Google Patents
Production of phenylalanine derivativesInfo
- Publication number
- GB1339101A GB1339101A GB375972A GB1339101DA GB1339101A GB 1339101 A GB1339101 A GB 1339101A GB 375972 A GB375972 A GB 375972A GB 1339101D A GB1339101D A GB 1339101DA GB 1339101 A GB1339101 A GB 1339101A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenylalanine
- aspartyl
- alkyl esters
- protected
- tertiary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
Abstract
1339101 α-L-Aspartyl-L-phenylalanine alkyl esters G D SEARLE & CO 26 Jan 1972 3759/72 Heading C2C α-L-Aspartyl-L-phenylalanine C 1-4 alkyl esters of the formula in which R is C 1-4 alkyl are obtained by reacting N-protected-L-aspartic anhydrides, in which the N atoms are protected by tertiary-butoxy carbonyl or tertiary-amyloxycarbonyl groups, with C 1-4 alkyl esters of phenylalanine in inert organic solvents to form mixtures of N-protected- α-L-aspartyl-L-phenylalanine C 1-4 alkyl esters and N-protected-#-L-aspartyl-L-phenylalanine C 1-4 alkyl esters: and thereafter either (a) separating all or substantially all of the N-protected-#-L-aspartyl-L-phenylalanine C 1-4 alkyl esters from the N-protected-α-L-aspartyl-L- phenylalanine C 1-4 alkyl esters and eliminating the N-protecting groups from the N-protected-α- L-aspartyl-L-phenylalanine C 1-4 alkyl esters, or (b) eliminating the N-protecting groups from the mixtures of N-protected-α- and #-aspartyl-L- phenylalanine C 1-4 alkyl esters and separating all or substantially all of the #-L-aspartyl-L- phenylalanine C 1-4 alkyl esters from the α-L- aspartyl-L-phenylalanine C 1-4 alkyl esters. N-Tertiary-butoxycarbonyl-L-aspartic anhydride and N-tertiary-amyloxycarbonyl-L-aspartic anhydride are obtained by reacting N-tertiarybutoxy-carbonylaspartic acid and N-tertiaryamyloxy-carbonylaspartic acid respectively with acetic anhydride.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB375972 | 1972-01-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1339101A true GB1339101A (en) | 1973-11-28 |
Family
ID=9764429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB375972A Expired GB1339101A (en) | 1972-01-26 | 1972-01-26 | Production of phenylalanine derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1339101A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2153365A (en) * | 1984-01-26 | 1985-08-21 | Pierrel Spa | Process for the preparation of N-acyl-derivatives of aspartame |
EP0214550A2 (en) * | 1985-09-09 | 1987-03-18 | Hoechst Aktiengesellschaft | Process for the preparation of aspartame and agent for its preparation |
-
1972
- 1972-01-26 GB GB375972A patent/GB1339101A/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2153365A (en) * | 1984-01-26 | 1985-08-21 | Pierrel Spa | Process for the preparation of N-acyl-derivatives of aspartame |
EP0214550A2 (en) * | 1985-09-09 | 1987-03-18 | Hoechst Aktiengesellschaft | Process for the preparation of aspartame and agent for its preparation |
EP0214550A3 (en) * | 1985-09-09 | 1988-08-10 | Hoechst Aktiengesellschaft | Process for the preparation of aspartame and agent for its preparation |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1243169A (en) | PRODUCTION OF alpha-L-ASPARTYL-L-PHENYLALANINE ALKYL ESTERS | |
GB1152977A (en) | Sweetening Agents | |
GB1429922A (en) | Steroid acetals processes for their manufacture and preparations containing them | |
GB1220623A (en) | 0,4-dihydro-1-substituted-6,7-methylene-dioxy-4-oxo-3-quinoline carboxylic acid derivatives | |
GB1359123A (en) | Preparation of aspartyl amino-acid alkyl esters | |
GB1465008A (en) | Mycophenolic acid deriv atives | |
GB1247612A (en) | Lincomycin derivatives and the manufacture thereof | |
GB1339101A (en) | Production of phenylalanine derivatives | |
GB1381320A (en) | Benzoxazole derivatives | |
GB1391139A (en) | Berbine derivatives and a process for producing the same | |
GB1158722A (en) | N-Thiocarboxyamino Acid Anhydrides | |
GB1299201A (en) | Medicaments derived from thiazolidine carboxylic acid | |
GB1322987A (en) | On,n-diacylhydroxylamine derivatives and preparation | |
GB1495679A (en) | Substituted isophthalamic acids | |
GB1173562A (en) | Chloramphenicol Ester Salts, the Preparation therof and Compositions Containing them | |
GB1203538A (en) | Cubane derivatives | |
GB1265648A (en) | ||
GB1515614A (en) | Preparation of m-benzoylhydratropic acid and an intermediate therefor | |
SE7403907L (en) | ||
SE336780B (en) | ||
GB1208230A (en) | Novel esters of 21-hydroxy-pregnanes, processes for their preparation, and compositions incorporating them | |
GB1251069A (en) | ||
GB1418595A (en) | N- 2-alkoxybenzoyl- amino acids and a process for producing the same | |
GB1322069A (en) | Aminoalkanoylaminocyclohexane derivatives | |
GB1407742A (en) | Preptide compounds and methods for their production |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PE20 | Patent expired after termination of 20 years |