GB1465008A - Mycophenolic acid deriv atives - Google Patents
Mycophenolic acid deriv ativesInfo
- Publication number
- GB1465008A GB1465008A GB1858374A GB1858374A GB1465008A GB 1465008 A GB1465008 A GB 1465008A GB 1858374 A GB1858374 A GB 1858374A GB 1858374 A GB1858374 A GB 1858374A GB 1465008 A GB1465008 A GB 1465008A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkoxy
- salts
- mycophenolic acid
- peracylated
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
Abstract
1465008 Mycophenolic acid derivatives ELI LILLY & CO 29 April 1974 [22 May 1973] 18583/74 Heading C2C Novel compounds I (in which R is OH, C 1-5 alkoxy or NH 2 and R<SP>1</SP> is # - D - glucopyranosyl, # - D - galactopyranosyl, # - D - allopyranosyl, # - D - gulopyranosyl, # - D - ribofuranosyl, # - D - ribopyranosyl or # - D - xylopyranosyl, or, when R is alkoxy, R<SP>1</SP> is one of said glycosyl radicals peracylated with C 2-4 alkanoyl or benzoyl) and pharmaceutically acceptable alkali-metal or alkaline-earthmetal salts thereof, are prepared by reacting an appropriate per-O-acylglycosyl halide with a C 1-5 alkyl mycophenolate, removing the acyl groups of the R<SP>1</SP> group in the resulting compound by treatment with a base and, if desired, hydrolysing, amidating or transesterifying the resulting compound I in which R is C 1-5 alkoxy. Salts are prepared from the free acids in known manner. Pharmaceutical compositions useful in the treatment of tumours, psoriasis and gout, for oral, parenteral or topical administration, comprise one of the above novel compounds or salts, provided that R<SP>1</SP> is not a peracylated radical, together with a pharmaceutical carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US362700A US3903071A (en) | 1973-05-22 | 1973-05-22 | Mycophenolic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1465008A true GB1465008A (en) | 1977-02-16 |
Family
ID=23427173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1858374A Expired GB1465008A (en) | 1973-05-22 | 1974-04-29 | Mycophenolic acid deriv atives |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US3903071A (en) |
| JP (1) | JPS5019747A (en) |
| AR (1) | AR201234A1 (en) |
| AT (1) | AT337892B (en) |
| BE (1) | BE815330A (en) |
| BG (1) | BG25994A3 (en) |
| CA (1) | CA1027558A (en) |
| CH (1) | CH603681A5 (en) |
| CS (1) | CS187435B2 (en) |
| DD (1) | DD113544A5 (en) |
| DE (1) | DE2424119A1 (en) |
| ES (1) | ES426543A1 (en) |
| FR (1) | FR2230361B1 (en) |
| GB (1) | GB1465008A (en) |
| HU (1) | HU169191B (en) |
| IE (1) | IE39218B1 (en) |
| IL (1) | IL44670A (en) |
| NL (1) | NL7406542A (en) |
| PH (1) | PH10898A (en) |
| PL (1) | PL89967B1 (en) |
| RO (1) | RO68642A (en) |
| SE (1) | SE7908625L (en) |
| SU (1) | SU578006A3 (en) |
| ZA (1) | ZA742417B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5414176Y2 (en) * | 1971-05-31 | 1979-06-13 | ||
| US4103006A (en) * | 1976-05-20 | 1978-07-25 | Wisconsin Alumni Research Foundation | Glycosides of 2,6-bis(hydroxy-phenyl)-3,7-dioxabicyclo [3,3,0] octane |
| US4686234A (en) * | 1985-11-27 | 1987-08-11 | Syntex (U.S.A) Inc. | Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis |
| US4725622A (en) * | 1986-01-23 | 1988-02-16 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
| US5177072A (en) * | 1987-01-30 | 1993-01-05 | Syntex (U.S.A.) Inc. | Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives |
| US4753935A (en) * | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
| JPH0736475Y2 (en) * | 1987-05-14 | 1995-08-16 | 阪神エレクトリック株式会社 | Inverter device |
| US5098899A (en) * | 1989-03-06 | 1992-03-24 | Trustees Of Boston University | Method for therapeutically treating psoriatic arthritis using vitamin D analogues and metabolites |
| US5455045A (en) * | 1993-05-13 | 1995-10-03 | Syntex (U.S.A.) Inc. | High dose formulations |
| ID18663A (en) | 1996-04-12 | 1998-04-30 | Novartis Ag | COMPOSITION OF PHARMACEUTICAL PLATED PHARMACEUTICALS |
| US20030050692A1 (en) * | 2000-12-22 | 2003-03-13 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
| US6471980B2 (en) | 2000-12-22 | 2002-10-29 | Avantec Vascular Corporation | Intravascular delivery of mycophenolic acid |
| US7083642B2 (en) * | 2000-12-22 | 2006-08-01 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
| US7077859B2 (en) * | 2000-12-22 | 2006-07-18 | Avantec Vascular Corporation | Apparatus and methods for variably controlled substance delivery from implanted prostheses |
| US20050203612A1 (en) * | 2000-12-22 | 2005-09-15 | Avantec Vascular Corporation | Devices delivering therapeutic agents and methods regarding the same |
| JP2005508671A (en) * | 2001-07-26 | 2005-04-07 | アバンテク バスキュラー コーポレーション | Delivery of therapeutically effective drugs |
| US6641611B2 (en) | 2001-11-26 | 2003-11-04 | Swaminathan Jayaraman | Therapeutic coating for an intravascular implant |
| WO2005051229A2 (en) * | 2003-11-24 | 2005-06-09 | Avantec Vascular Corporation | Devices delivering therapeutic agents and methods regarding the same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3758455A (en) * | 1970-05-14 | 1973-09-11 | Chugai Pharmaceutical Co Ltd | Reof mycophenolic acid glucuronide and the process for the preparation the |
-
1973
- 1973-05-22 US US362700A patent/US3903071A/en not_active Expired - Lifetime
-
1974
- 1974-04-06 ZA ZA00742417A patent/ZA742417B/en unknown
- 1974-04-17 CA CA197,708A patent/CA1027558A/en not_active Expired
- 1974-04-17 IE IE806/74A patent/IE39218B1/en unknown
- 1974-04-19 IL IL44670A patent/IL44670A/en unknown
- 1974-04-19 PH PH15753A patent/PH10898A/en unknown
- 1974-04-29 GB GB1858374A patent/GB1465008A/en not_active Expired
- 1974-05-06 CH CH613674A patent/CH603681A5/xx not_active IP Right Cessation
- 1974-05-15 NL NL7406542A patent/NL7406542A/xx not_active Application Discontinuation
- 1974-05-17 DE DE2424119A patent/DE2424119A1/en not_active Withdrawn
- 1974-05-21 AT AT421274A patent/AT337892B/en not_active IP Right Cessation
- 1974-05-21 HU HUEI550A patent/HU169191B/hu unknown
- 1974-05-21 ES ES426543A patent/ES426543A1/en not_active Expired
- 1974-05-21 FR FR7417688A patent/FR2230361B1/fr not_active Expired
- 1974-05-21 BE BE1005977A patent/BE815330A/en unknown
- 1974-05-21 SU SU7402026935A patent/SU578006A3/en active
- 1974-05-21 PL PL1974171297A patent/PL89967B1/pl unknown
- 1974-05-22 AR AR253880A patent/AR201234A1/en active
- 1974-05-22 DD DD178682A patent/DD113544A5/xx unknown
- 1974-05-22 BG BG7426761A patent/BG25994A3/xx unknown
- 1974-05-22 RO RO7478897A patent/RO68642A/en unknown
- 1974-05-22 CS CS743663A patent/CS187435B2/en unknown
- 1974-05-22 JP JP49058339A patent/JPS5019747A/ja active Pending
-
1979
- 1979-10-17 SE SE7908625A patent/SE7908625L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE39218B1 (en) | 1978-08-30 |
| BE815330A (en) | 1974-11-21 |
| SU578006A3 (en) | 1977-10-25 |
| DD113544A5 (en) | 1975-06-12 |
| IE39218L (en) | 1974-11-22 |
| FR2230361B1 (en) | 1977-01-28 |
| SE7908625L (en) | 1979-10-17 |
| RO68642A (en) | 1980-06-15 |
| ATA421274A (en) | 1976-11-15 |
| ZA742417B (en) | 1975-11-26 |
| AT337892B (en) | 1977-07-25 |
| IL44670A0 (en) | 1974-06-30 |
| FR2230361A1 (en) | 1974-12-20 |
| JPS5019747A (en) | 1975-03-01 |
| AU6802774A (en) | 1975-10-23 |
| PL89967B1 (en) | 1976-12-31 |
| CH603681A5 (en) | 1978-08-31 |
| NL7406542A (en) | 1974-11-26 |
| BG25994A3 (en) | 1979-01-12 |
| AR201234A1 (en) | 1975-02-21 |
| CS187435B2 (en) | 1979-01-31 |
| HU169191B (en) | 1976-10-28 |
| ES426543A1 (en) | 1976-07-01 |
| IL44670A (en) | 1977-08-31 |
| CA1027558A (en) | 1978-03-07 |
| PH10898A (en) | 1977-09-30 |
| US3903071A (en) | 1975-09-02 |
| DE2424119A1 (en) | 1974-12-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |