GB1305860A - - Google Patents
Info
- Publication number
- GB1305860A GB1305860A GB5880771A GB5880771A GB1305860A GB 1305860 A GB1305860 A GB 1305860A GB 5880771 A GB5880771 A GB 5880771A GB 5880771 A GB5880771 A GB 5880771A GB 1305860 A GB1305860 A GB 1305860A
- Authority
- GB
- United Kingdom
- Prior art keywords
- doxycycline
- volume
- organic solvent
- aqueous organic
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960003722 doxycycline Drugs 0.000 abstract 9
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 abstract 6
- YCPXWRQRBFJBPZ-UHFFFAOYSA-N 5-sulfosalicylic acid Chemical compound OC(=O)C1=CC(S(O)(=O)=O)=CC=C1O YCPXWRQRBFJBPZ-UHFFFAOYSA-N 0.000 abstract 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000003960 organic solvent Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229940042016 methacycline Drugs 0.000 abstract 1
- MHIGBKBJSQVXNH-IWVLMIASSA-N methacycline Chemical compound C=C([C@H]1[C@@H]2O)C3=CC=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O MHIGBKBJSQVXNH-IWVLMIASSA-N 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT338071 | 1971-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1305860A true GB1305860A (enrdf_load_stackoverflow) | 1973-02-07 |
Family
ID=11106027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5880771A Expired GB1305860A (enrdf_load_stackoverflow) | 1971-03-31 | 1971-12-17 |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT309680B (enrdf_load_stackoverflow) |
| BE (1) | BE770527A (enrdf_load_stackoverflow) |
| DE (1) | DE2136622A1 (enrdf_load_stackoverflow) |
| ES (1) | ES394777A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2131926A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1305860A (enrdf_load_stackoverflow) |
| NL (1) | NL7109741A (enrdf_load_stackoverflow) |
| ZA (1) | ZA714767B (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077822A (en) * | 1993-09-14 | 2000-06-20 | Dumex-Alpharma A/S | Drug salts |
| CN111443139A (zh) * | 2020-03-13 | 2020-07-24 | 扬州联博药业有限公司 | 一种同时检测盐酸多西环素中多西环素及有关物质相对保留时间和峰纯度的方法 |
| CN114835603A (zh) * | 2022-06-17 | 2022-08-02 | 盐城苏海制药有限公司 | 一种由氢化物直接合成盐酸多西环素的合成方法 |
-
1971
- 1971-07-14 NL NL7109741A patent/NL7109741A/xx unknown
- 1971-07-19 ZA ZA714767A patent/ZA714767B/xx unknown
- 1971-07-22 DE DE19712136622 patent/DE2136622A1/de active Pending
- 1971-07-23 AT AT643771A patent/AT309680B/de active
- 1971-07-27 BE BE770527A patent/BE770527A/nl unknown
- 1971-09-03 ES ES394777A patent/ES394777A1/es not_active Expired
- 1971-10-13 FR FR7136764A patent/FR2131926A1/fr not_active Withdrawn
- 1971-12-17 GB GB5880771A patent/GB1305860A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077822A (en) * | 1993-09-14 | 2000-06-20 | Dumex-Alpharma A/S | Drug salts |
| CN111443139A (zh) * | 2020-03-13 | 2020-07-24 | 扬州联博药业有限公司 | 一种同时检测盐酸多西环素中多西环素及有关物质相对保留时间和峰纯度的方法 |
| CN114835603A (zh) * | 2022-06-17 | 2022-08-02 | 盐城苏海制药有限公司 | 一种由氢化物直接合成盐酸多西环素的合成方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2131926A1 (fr) | 1972-11-17 |
| ES394777A1 (es) | 1974-03-01 |
| NL7109741A (enrdf_load_stackoverflow) | 1972-10-03 |
| BE770527A (nl) | 1971-12-01 |
| DE2136622A1 (enrdf_load_stackoverflow) | 1972-10-12 |
| ZA714767B (en) | 1972-10-25 |
| AT309680B (de) | 1973-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 414F | Notice of opposition given (sect. 14/1949) | ||
| 414E | Application relinquished (sect. 14/1949) | ||
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |