ES394777A1 - Procedimiento para aislar y purificar 6 - alfa - desoxi - 5 - hidroxitetraciclina. - Google Patents
Procedimiento para aislar y purificar 6 - alfa - desoxi - 5 - hidroxitetraciclina.Info
- Publication number
- ES394777A1 ES394777A1 ES394777A ES394777A ES394777A1 ES 394777 A1 ES394777 A1 ES 394777A1 ES 394777 A ES394777 A ES 394777A ES 394777 A ES394777 A ES 394777A ES 394777 A1 ES394777 A1 ES 394777A1
- Authority
- ES
- Spain
- Prior art keywords
- doxycycline
- translation
- procedure
- machine
- catalytic hydrogenation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 abstract 6
- 229960003722 doxycycline Drugs 0.000 abstract 6
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 3
- YCPXWRQRBFJBPZ-UHFFFAOYSA-N 5-sulfosalicylic acid Chemical compound OC(=O)C1=CC(S(O)(=O)=O)=CC=C1O YCPXWRQRBFJBPZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WXHLLJAMBQLULT-UHFFFAOYSA-N 2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-n-(2-methyl-6-sulfanylphenyl)-1,3-thiazole-5-carboxamide;hydrate Chemical compound O.C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1S WXHLLJAMBQLULT-UHFFFAOYSA-N 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- MOODSJOROWROTO-UHFFFAOYSA-N salicylsulfuric acid Chemical compound OC(=O)C1=CC=CC=C1OS(O)(=O)=O MOODSJOROWROTO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229940071103 sulfosalicylate Drugs 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- -1 tetracycline compound Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT338071 | 1971-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES394777A1 true ES394777A1 (es) | 1974-03-01 |
Family
ID=11106027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES394777A Expired ES394777A1 (es) | 1971-03-31 | 1971-09-03 | Procedimiento para aislar y purificar 6 - alfa - desoxi - 5 - hidroxitetraciclina. |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT309680B (enrdf_load_stackoverflow) |
| BE (1) | BE770527A (enrdf_load_stackoverflow) |
| DE (1) | DE2136622A1 (enrdf_load_stackoverflow) |
| ES (1) | ES394777A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2131926A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1305860A (enrdf_load_stackoverflow) |
| NL (1) | NL7109741A (enrdf_load_stackoverflow) |
| ZA (1) | ZA714767B (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077822A (en) * | 1993-09-14 | 2000-06-20 | Dumex-Alpharma A/S | Drug salts |
| CN111443139A (zh) * | 2020-03-13 | 2020-07-24 | 扬州联博药业有限公司 | 一种同时检测盐酸多西环素中多西环素及有关物质相对保留时间和峰纯度的方法 |
| CN114835603A (zh) * | 2022-06-17 | 2022-08-02 | 盐城苏海制药有限公司 | 一种由氢化物直接合成盐酸多西环素的合成方法 |
-
1971
- 1971-07-14 NL NL7109741A patent/NL7109741A/xx unknown
- 1971-07-19 ZA ZA714767A patent/ZA714767B/xx unknown
- 1971-07-22 DE DE19712136622 patent/DE2136622A1/de active Pending
- 1971-07-23 AT AT643771A patent/AT309680B/de active
- 1971-07-27 BE BE770527A patent/BE770527A/nl unknown
- 1971-09-03 ES ES394777A patent/ES394777A1/es not_active Expired
- 1971-10-13 FR FR7136764A patent/FR2131926A1/fr not_active Withdrawn
- 1971-12-17 GB GB5880771A patent/GB1305860A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2131926A1 (fr) | 1972-11-17 |
| NL7109741A (enrdf_load_stackoverflow) | 1972-10-03 |
| BE770527A (nl) | 1971-12-01 |
| DE2136622A1 (enrdf_load_stackoverflow) | 1972-10-12 |
| ZA714767B (en) | 1972-10-25 |
| AT309680B (de) | 1973-08-27 |
| GB1305860A (enrdf_load_stackoverflow) | 1973-02-07 |
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